Emerging Cell-Based Therapies in Chronic Lung Diseases: What About Asthma?

Asthma is a widespread disease characterized by chronic airway inflammation. It causes substantial disability, impaired quality of life, and avoidable deaths around the world. The main treatment for asthmatic patients is the administration of corticosteroids, which improves the quality of life; however, prolonged use of corticosteroids interferes with extracellular matrix elements. Therefore, cell-based therapies are emerging as a novel therapeutic contribution to tissue regeneration for lung diseases. This study aimed to summarize the advancements in cell therapy involving mesenchymal stromal cells, extracellular vesicles, and immune cells such as T-cells in asthma. Our findings provide evidence that the use of mesenchymal stem cells, their derivatives, and immune cells such as T-cells are an initial milestone to understand how emergent cell-based therapies are effective to face the challenges in the development, progression, and management of asthma, thus improving the quality of life.

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Lung Function and Quality of Life in Workers with Chemical and Dust Exposure

Revista de Chimie ◽

10.37358/rc.18.2.6104 ◽

2018 ◽

Vol 69 (2) ◽

pp. 346-349 ◽

Cited By ~ 1

Author(s):

Marina Ruxandra Otelea ◽

Oana Cristina Arghir ◽

Corina Zugravu ◽

Eugenia Naghi ◽

Sabina Antoniu ◽

...

Keyword(s):

Quality Of Life ◽

Occupational Exposure ◽

Lung Function ◽

Lung Diseases ◽

Dust Exposure ◽

Chronic Lung Diseases ◽

Respiratory Exposure ◽

Increased Risk ◽

Occupational Settings

Regarding the widely distribution of respiratory exposure hazards in occupational settings, workers have an increased risk for chronic lung diseases. For assessing the quality of life and lung function in workers exposed to chemicals and dust, St George�s Respiratory Questionnaire (SGRQ) and spirometry were performed among 40 patients, admitted in Occupational Clinic Department of Colentina Hospital, Bucharest, Romania, during February, 2017. SGRQ showed different predictors for patients according to their occupational exposure and total symptoms score correlated better with decreased spirometric parameters in defining lung function deterioration. Quality of life is earlier affected than lung function deterioration and emphasises the need of more sensitive methods for an earlier identification and better evaluation of respiratory hazards in different workplaces.

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Long-Term Adherence and Maintenance of Benefits in Pulmonary Rehabilitation

Update in Respiratory Diseases ◽

10.5772/intechopen.90565 ◽

2020 ◽

Author(s):

Hulya Sahin

Keyword(s):

Quality Of Life ◽

Pulmonary Rehabilitation ◽

Lung Diseases ◽

Functional Dependence ◽

Daily Life Activities ◽

Chronic Lung Diseases ◽

Maintenance Program ◽

Decrease Decrease

Pulmonary rehabilitation (PR) is a comprehensive intervention in chronic lung diseases, including personalized special therapies, exercise training, education and behavioral changes to improve the physical and psychological status of the patients, and aims to promote behavior that helps improve health status in the long term. A personalized PR program administered by a multidisciplinary team is recently considered a standard and complementary treatment method in chronic lung diseases. After the PR program, dyspnea of COPD patients decreases and their exercise capacities increase. Their daily life activities and physical activities increase. Their functional dependence decreases and quality of life increases. It presents a perfect opportunity to provide self-management and independence for the patients and improve their quality of life. Studies have shown that, unless there is a structured maintenance program, after an average of 6–12 months following PR programs, the gains that are realized start to decrease. Decrease of gains due to causes like a decrease in compliance to exercises, disease progress, attacks and co-morbidities. Causes such as decreased compliance to exercise, progression of the disease, attacks and comorbidities play a role in reducing gains. Especially in advanced age and in the presence of severe disease, the gain in exercise tolerance is lost more rapidly. The methods used and the results obtained to ensure the continuation of the gains differ.

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THE IMPACT OF CHRONIC LUNG DISEASES ON THE QUALITY OF LIFE OF PATIENTS MEASURED BOTH BY DISEASE SPECIFIC AND GENERIC INSTRUMENTS

CHEST Journal ◽

10.1378/chest.128.4_meetingabstracts.393s-b ◽

2005 ◽

Vol 128 (4) ◽

pp. 393S

Author(s):

Siu Pui Lam ◽

Pui Shan Lam ◽

Wai Woon Ho ◽

Ho Pui So

Keyword(s):

Quality Of Life ◽

Lung Diseases ◽

Chronic Lung Diseases ◽

The Impact ◽

Disease Specific

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Pulmonary Rehabilitation In Covid-19: The Contribution Of Other Chronic Lung Syndromes For The Intervention Of A Novel Disease.

Current Respiratory Medicine Reviews ◽

10.2174/1573398x17666210129124433 ◽

2021 ◽

Vol 17 ◽

Author(s):

Vicente Benavides-Córdoba ◽

Diana Guerrero-Jaramillo ◽

Jhonatan Betancourt-Peña

Keyword(s):

Quality Of Life ◽

Functional Capacity ◽

Pulmonary Rehabilitation ◽

Lung Diseases ◽

Neuromuscular Disorders ◽

Chronic Lung Diseases ◽

The World

COVID-19 has spread throughout the world causing a significant number of cases of pneumonia and SARS. Patients with COVID-19 may also have other cardiovascular, respiratory, and neuromuscular disorders. These multisystemic complications present the need for comprehensive interventions focused on improving symptoms, functional capacity, and quality of life. Pulmonary rehabilitation has the potential to offer some of these benefits. However, the evidence related to specific aspects of pulmonary rehabilitation evaluation and intervention in COVID19 is limited. We have learned from experiences with other types of chronic lung diseases that have used pulmonary rehabilitation successfully, so that while the own evidence of rehabilitation emerges in COVID-19, it is necessary to establish some initial recommendations, prepared according to the sequelae found until now.

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