scholarly journals Effect of Oral Docosahexaenoic Acid (DHA) Supplementation on DHA Levels and Omega-3 Index in Red Blood Cell Membranes of Breast Cancer Patients

2017 ◽  
Vol 8 ◽  
Author(s):  
Alessio Molfino

2017 ◽  
Vol 124 ◽  
pp. 11-16 ◽  
Author(s):  
Colleen A. Parks ◽  
Neil R. Brett ◽  
Sherry Agellon ◽  
Paula Lavery ◽  
Catherine A. Vanstone ◽  
...  


Metabolites ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 469
Author(s):  
Javier Amézaga ◽  
Gurutze Ugartemendia ◽  
Aitziber Larraioz ◽  
Nerea Bretaña ◽  
Aizpea Iruretagoyena ◽  
...  

Red blood cell (RBC) membrane can reflect fatty acid (FA) contribution from diet and biosynthesis. In cancer, membrane FAs are involved in tumorigenesis and invasiveness, and are indicated as biomarkers to monitor the disease evolution as well as potential targets for therapies and nutritional strategies. The present study provides RBC membrane FA profiles in recently diagnosed breast cancer patients before starting chemotherapy treatment. Patients and controls were recruited, and their dietary habits were collected. FA lipidomic analysis of mature erythrocyte membrane phospholipids in blood samples was performed. Data were adjusted to correct for the effects of diet, body mass index (BMI), and age, revealing that patients showed lower levels of saturated fatty acids (SFA) and higher levels of monounsaturated fatty acid, cis-vaccenic (25%) than controls, with consequent differences in desaturase enzymatic index (∆9 desaturase, –13.1%). In the case of polyunsaturated fatty acids (PUFA), patients had higher values of ω-6 FA (C18:2 (+11.1%); C20:4 (+7.4%)). RBC membrane lipidomic analysis in breast cancer revealed that ω-6 pathways are favored. These results suggest new potential targets for treatments and better nutritional guidelines.



GeroScience ◽  
2022 ◽  
Author(s):  
Bertrand Fougère ◽  
Sabine Goisser ◽  
Christelle Cantet ◽  
Gaëlle Soriano ◽  
Sophie Guyonnet ◽  
...  


1998 ◽  
Vol 26 (2) ◽  
pp. S142-S142 ◽  
Author(s):  
Rhian Edwards ◽  
Malcolm Peet ◽  
Janet Shay ◽  
David Horrobin


1998 ◽  
Vol 43 (5) ◽  
pp. 315-319 ◽  
Author(s):  
Malcolm Peet ◽  
Brendan Murphy ◽  
Janet Shay ◽  
David Horrobin


GeroScience ◽  
2017 ◽  
Vol 39 (4) ◽  
pp. 429-437 ◽  
Author(s):  
Bertrand Fougère ◽  
◽  
Sabine Goisser ◽  
Christelle Cantet ◽  
Gaëlle Soriano ◽  
...  


1998 ◽  
Vol 42 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Hildegunn Berntsen ◽  
Per Eystein Lønning ◽  
Dagfinn Ekse ◽  
Bjørn Netteland ◽  
Dag Clement Johannessen ◽  
...  


2017 ◽  
Vol 19 (1) ◽  
Author(s):  
Anne Marie L. Thomsen ◽  
Alma B. Pedersen ◽  
Nickolaj R. Kristensen ◽  
Bjarne Kuno Møller ◽  
Christian Erikstrup ◽  
...  


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