Influence of treatment with aminoglutethimide on plasma and red-blood-cell glutathione status in breast cancer patients

Red blood cell (RBC) membrane can reflect fatty acid (FA) contribution from diet and biosynthesis. In cancer, membrane FAs are involved in tumorigenesis and invasiveness, and are indicated as biomarkers to monitor the disease evolution as well as potential targets for therapies and nutritional strategies. The present study provides RBC membrane FA profiles in recently diagnosed breast cancer patients before starting chemotherapy treatment. Patients and controls were recruited, and their dietary habits were collected. FA lipidomic analysis of mature erythrocyte membrane phospholipids in blood samples was performed. Data were adjusted to correct for the effects of diet, body mass index (BMI), and age, revealing that patients showed lower levels of saturated fatty acids (SFA) and higher levels of monounsaturated fatty acid, cis-vaccenic (25%) than controls, with consequent differences in desaturase enzymatic index (∆9 desaturase, –13.1%). In the case of polyunsaturated fatty acids (PUFA), patients had higher values of ω-6 FA (C18:2 (+11.1%); C20:4 (+7.4%)). RBC membrane lipidomic analysis in breast cancer revealed that ω-6 pathways are favored. These results suggest new potential targets for treatments and better nutritional guidelines.

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Effect of Oral Docosahexaenoic Acid (DHA) Supplementation on DHA Levels and Omega-3 Index in Red Blood Cell Membranes of Breast Cancer Patients

Frontiers in Physiology ◽

10.3389/fphys.2017.00549 ◽

2017 ◽

Vol 8 ◽

Cited By ~ 9

Author(s):

Alessio Molfino

Keyword(s):

Breast Cancer ◽

Docosahexaenoic Acid ◽

Blood Cell ◽

Cancer Patients ◽

Red Blood Cell ◽

Cell Membranes ◽

Breast Cancer Patients ◽

Omega 3 ◽

Red Blood Cell Membranes

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Use of prescription drugs and risk of postoperative red blood cell transfusion in breast cancer patients: a Danish population-based cohort study

Breast Cancer Research ◽

10.1186/s13058-017-0926-2 ◽

2017 ◽

Vol 19 (1) ◽

Author(s):

Anne Marie L. Thomsen ◽

Alma B. Pedersen ◽

Nickolaj R. Kristensen ◽

Bjarne Kuno Møller ◽

Christian Erikstrup ◽

...

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Blood Cell ◽

Cancer Patients ◽

Prescription Drugs ◽

Red Blood Cell ◽

Population Based ◽

Red Blood Cell Transfusion ◽

Breast Cancer Patients ◽

Danish Population

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Correlation Between TILs and Blood Cell Counts in Triple Negative Breast Cancer Patients

Case Medical Research ◽

10.31525/ct1-nct04068623 ◽

2019 ◽

Author(s):

Keyword(s):

Breast Cancer ◽

Blood Cell ◽

Cancer Patients ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Breast Cancer Patients ◽

Cell Counts ◽

Blood Cell Counts

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Combining contrast-enhanced ultrasound and blood cell analysis to improve diagnostic accuracy of plasma cell mastitis

Experimental Biology and Medicine ◽

10.1177/15353702211049361 ◽

2021 ◽

pp. 153537022110493

Author(s):

Yan Zheng ◽

Lin Wang ◽

Xiu Han ◽

Lin Shen ◽

Chen Ling ◽

...

Keyword(s):

Breast Cancer ◽

Blood Cell ◽

Diagnostic Accuracy ◽

Cancer Patients ◽

Plasma Cell ◽

Perfusion Defect ◽

Cell Analysis ◽

Contrast Enhanced Ultrasound ◽

Breast Cancer Patients ◽

Contrast Enhanced

Plasma cell mastitis is a benign suppurative disease of the breast, lack of specific clinical manifestations, which is easy to be misdiagnosed and mistreated, often confused with mastitis, breast cancer (BC), and other diseases. Thus, we aimed to establish a combined model of promoting diagnostic accuracy of plasma cell mastitis by contrast-enhanced ultrasound (CEUS) patterns and routine blood cell analysis. Eighty-eight plasma cell mastitis, 91 breast cancer, and 152 other benign breast diseases’ patients grouped according to pathological diagnosis underwent CEUS and blood cell analysis examination; 100 healthy female donors were involved. All the plasma cell mastitis and breast cancer patients presented hyperenhancement of CEUS breast lesions compared with others. The majority of plasma cell mastitis (65/88) showed perfusion defect of CEUS patterns with smooth edge (56/65) and multiple lesions (49/65); in contrast, fewer breast cancer patients (30/91) displayed perfusion defect. White blood cell count (WBC), neutrophils, and neutrophils/lymphocytes ratio of blood cell analysis in plasma cell mastitis patients increased significantly compared with other patients ( P < 0.0001). Combining perfusion defect of CEUS patterns and WBC yielded an area under the receiver operating characteristic curve of 0.831, higher than single 0.720 and 0.774, respectively. The cut-off value of WBC (7.28 × 109/L) helped remaining 65.2% (15/23) atypical cases to be correctly diagnosed as plasma cell mastitis, not misdiagnosed as breast cancer. In conclusion, CEUS presented a clear perfusion defect pattern of plasma cell mastitis lesion for the first time. A precise WBC by routine blood cell analysis test can assist CEUS examination in the differential diagnosis of plasma cell mastitis and breast cancer. It is a promised combination for laboratory diagnostic of PCM.

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Longterm blood cell counts after intraoperative radiotherapy with or without whole breast radiotherapy in breast cancer patients.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e12014 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e12014-e12014

Author(s):

Elena Sperk ◽

Cornelia Wersal ◽

Christel Weiss ◽

Anke Keller ◽

Anette Kipke ◽

...

Keyword(s):

Breast Cancer ◽

Blood Cell ◽

Cancer Patients ◽

Cell Lines ◽

Breast Cancer Patients ◽

Breast Radiotherapy ◽

Cell Counts ◽

Blood Cell Counts ◽

Whole Breast Radiotherapy

e12014 Background: After radiotherapy changes in blood cell counts (BCC) can be seen. Leukocytopenia may have a negative impact on the immune system, outcome and quality of life of breast cancer survivors. No reports on changes of the three blood cell lines (leukocytes=WBC, erythrocytes=RBC, thrombocytes=PLT) after IORT w/o whole breast radiotherapy (WBRT) in breast cancer patients have been reported. Methods: 256 patients had IORT during breast conserving surgery. In 198 patients WBRT (46-50Gy/2Gy) + IORT (20Gy) and in 58 patients IORT as accelerated partial breast irradiation=APBI (20Gy) was given. Preoperative BCC were used as baseline. In 214 patients BCC were available after 1-90 days, in 139 during the 1st year, in 86 in the 2nd, in 66 in the 3rd, in 51 in the 4th and in 34 in the 5th year of follow-up. Dunnett-tests were used to calculate adjusted p-values (p<0.05=significant). Results: After IORT/WBRT a decrease of WBC was seen during the 1st year. Afterwards no changes were seen. After IORT APBI no changes were seen during 5 years follow-up. RBC was decreased at all time points after IORT/WBRT, and through the 1st year after IORT APBI. PLT decreased during the 1st year and stayed low during 5 years after IORT/WBRT. No changes in PLT were seen after IORT APBI. Hemoglobin (HGB) decreased after 3 months, during the 1st and 5th year after IORT/WBRT. After IORT APBI, HGB decreased only during the 1st year and stayed stable during follow-up. Conclusions: Decreases of all blood cell lines were seen at least transiently after IORT/WBRT. PLT and RBC stayed decreased. After IORT APBI, HGB and RBC decreased only during the 1st year and WBC and PLT remained stable during the whole follow-up. [Table: see text]

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Prognostic value of pre-treatment routine hematological parameters in breast carcinoma: Advantageous or deleterious?

Biomedical Research and Therapy ◽

10.15419/bmrat.v7i8.621 ◽

2020 ◽

Vol 7 (8) ◽

pp. 3916-3920

Author(s):

Manigatta Doddagowda Shilpa ◽

Raju Kalyani ◽

P N Sreeramulu

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Blood Cell ◽

Cancer Patients ◽

Hematological Parameters ◽

Hemoglobin Concentration ◽

Study Group ◽

Breast Cancer Patients ◽

Wbc Count ◽

Rbc Count

Introduction: The most common malignancy which endangers the quality of life in females is breast cancer. It is also the major public problem in society and despite advances in treatment strategies, it still leads to high mortality. In all breast cancer patients, the first assessment done before surgery is the complete blood count (CBC). There exists a strong relationship between immune response of the body and clinical staging of breast cancer. This study aimed to determine the most reliable hematological markers for the prognosis of breast cancer, and to evaluate the correlation between hematological parameters and disease staging. Methods: This study was a case control study conducted for a period of 3 years from Jan 2016 to December 2018 in the Department of Pathology (R.L. hospital and Research Center attached to Sri Devaraj Urs medical college, Tamaka, Kolar, Karnataka). The comparison of the hematological parameters was done between the study group (70 cases) and the control group (20 cases). The relation between the hematological parameters and the various stages of breast cancer was analyzed before initiating the treatment. Results: The majority of the breast cancer patients were of stage 2. The hemoglobin concentration, red blood cell (RBC) count, lymphocyte count, and were reduced in the study group, with a significant difference (p < 0.05) when compared to the controls. Hemoglobin concentration, RBC count, hematocrit, white blood cell (WBC) count, and absolute lymphocyte count were inversely proportional to the stage of breast cancer. The absolute count, ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were directly proportional to the progression of disease. Conclusion: Hemoglobin, RBC count, WBC count (including differential count), NLR, and PLR are the key hematological indicators which predict the severity and mortality risk of breast carcinoma.

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Tai Chi Chuan improves cytokine expression levels and quality of life in post chemotherapy breast cancer survivors

World Journal of Advanced Research and Reviews ◽

10.30574/wjarr.2021.10.3.0244 ◽

2021 ◽

Vol 10 (3) ◽

pp. 322-333

Author(s):

Mary NB Cheung ◽

Tjing Yung Loo

Keyword(s):

Breast Cancer ◽

Blood Cell ◽

Cancer Patients ◽

Biological Markers ◽

Tai Chi ◽

Ductal Carcinoma ◽

Breast Cancer Patients ◽

Tai Chi Chuan ◽

Hand Grip ◽

Rbc Count

Background: This study investigated the effects of Tai Chi Chuan (TCC) exercise on biological markers and psychological factors of breast carcinoma patients diagnosed with advanced invasive ductal carcinoma. Methods: Sixty breast cancer patients, and 50 healthy female subjects. Patients underwent a mastectomy for invasive ductal carcinoma, and completed 4 cycles of 5-fluorouracil, epirubicin and cyclophosphamide chemotherapy. Peripheral blood was drawn from subjects to analyze the biological markers, namely white blood cell (WBC) and red blood cell (RBC) count and cytokine levels (IL2, IL4, IL6, IFN-γ and TNF-α). Following treatment, the patients participated in a TCC program for 12 months. Biomarkers and hand grip strength were measured at baseline, 6 and 12 months after TCC practice. A psychological factor-based questionnaire was also conducted. Results: After 12 months of TCC, the levels of cytokines of patients achieved no statistically significant difference compared to healthy controls. The total WBC count was 7.55 ± 1.25 (p<0.05), and the total RBC count was 4.62±1.25 (p<0.05). Patients noticed improvements in short term memory. Following 12 months of TCC practice, patients also had stronger hand grip strength with baseline. Conclusions: TCC exercise can recommended for the rehabilitation of post-treatment breast cancer patients for biological and psychological improvements.

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