scholarly journals COVID-19 Sepsis and Microcirculation Dysfunction

2020 ◽  
Vol 11 ◽  
Author(s):  
Antonio Colantuoni ◽  
Romeo Martini ◽  
Patrizia Caprari ◽  
Marco Ballestri ◽  
Pier Leopoldo Capecchi ◽  
...  
Keyword(s):  
Microcirculation Dysfunction

Assessing and managing coronary microcirculation dysfunction in acute ST-segment elevation myocardial infarction

2018 ◽  
Vol 17 (2) ◽  
pp. 111-126 ◽  
Author(s):  
Richard Armstrong ◽  
Giovanni Luigi De Maria ◽  
Roberto Scarsini ◽  
Adrian P. Banning
Keyword(s):  
Myocardial Infarction ◽  
Coronary Microcirculation ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Microcirculation Dysfunction

scholarly journals ACETYLCHOLINE INJECTION CAUSES CORONARY ARTERY SPASM AND CORONARY ARTERY MICROCIRCULATION DYSFUNCTION—A CLINICAL RESEARCH

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E191.2-E191
Author(s):  
Yingjun Zhao ◽  
Na Zhang ◽  
Yingjun Zhao
Keyword(s):  
Coronary Artery ◽  
Clinical Research ◽  
Coronary Artery Spasm ◽  
Microcirculation Dysfunction

Systemic microcirculation dysfunction after low thoracic spinal cord injury in mice

Life Sciences ◽  
2019 ◽  
Vol 221 ◽  
pp. 47-55
Author(s):  
Xiaochen Yuan ◽  
Qingbin Wu ◽  
Yinshan Tang ◽  
Yingli Jing ◽  
Zhigang Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury ◽  
Microcirculation Dysfunction

Peripheral microcirculation dysfunction evaluated by computed tomography perfusion study in Fabry patients

2011 ◽  
Vol 19 (1) ◽  
pp. e4-e6 ◽  
Author(s):  
L.-S. Ro ◽  
M.-F. Liao ◽  
C.-J. Chen ◽  
Y.-T. Lau ◽  
K.-T. Lu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Perfusion Study ◽  
Computed Tomography Perfusion ◽  
Peripheral Microcirculation ◽  
Microcirculation Dysfunction

scholarly journals Pathophysiology of Takotsubo Syndrome as A Bridge to Personalized Treatment

2021 ◽  
Vol 11 (9) ◽  
pp. 879
Author(s):  
Monika Budnik ◽  
Radosław Piątkowski ◽  
Dorota Ochijewicz ◽  
Martyna Zaleska ◽  
Marcin Grabowski ◽  
...  
Keyword(s):  
Nervous System ◽  
Genetic Factors ◽  
Personalized Treatment ◽  
Takotsubo Syndrome ◽  
Primary Condition ◽  
Psychiatric Conditions ◽  
Sympathetic Nervous ◽  
Vessel Dissection ◽  
The Brain ◽  
Microcirculation Dysfunction

Takotsubo syndrome (TTS) consists of transient dysfunction of the left and/or right ventricle in the absence of ruptured plaque; thrombus or vessel dissection. TTS may be divided into two categories. Primary TTS occurs when the cause of hospitalization is the symptoms resulting from damage to the myocardium usually preceded by emotional stress. Secondary TTS occurs in patients hospitalized for other medical; surgical; anesthetic; obstetric or psychiatric conditions who have activation of their sympathetic nervous system and catecholamines release- they develop TTS as a complication of their primary condition or its treatment. There are several hypotheses concerning the cause of the disease. They include a decrease in estrogen levels; microcirculation dysfunction; endothelial dysfunction and the hypothesis based on the importance of the brain-heart axis. More and more research concerns the importance of genetic factors in the development of the disease. To date; no effective treatment or prevention of recurrent TTS has been found. Only when the pathophysiology of the disease is fully known; then personalized treatment will be possible.

scholarly journals Intramuscular Exposure to a Lethal Dose of Ricin Toxin Leads to Endothelial Glycocalyx Shedding and Microvascular Flow Abnormality in Mice and Swine

2021 ◽  
Vol 22 (22) ◽  
pp. 12345
Author(s):  
Anita Sapoznikov ◽  
Yoav Gal ◽  
Yentl Evgy ◽  
Moshe Aftalion ◽  
Shahaf Katalan ◽  
...  
Keyword(s):  
Ricinus Communis ◽  
Lethal Dose ◽  
Clinical Manifestations ◽  
Dark Field ◽  
Endothelial Glycocalyx ◽  
Microscopy Imaging ◽  
Ricin Toxin ◽  
Side Stream ◽  
Clinical Consequences ◽  
Microcirculation Dysfunction

Ricin toxin isolated from the castor bean (Ricinus communis) is one of the most potent and lethal molecules known. While the pathophysiology and clinical consequences of ricin poisoning by the parenteral route, i.e., intramuscular penetration, have been described recently in various animal models, the preceding mechanism underlying the clinical manifestations of systemic ricin poisoning has not been completely defined. Here, we show that following intramuscular administration, ricin bound preferentially to the vasculature in both mice and swine, leading to coagulopathy and widespread hemorrhages. Increased levels of circulating VEGF and decreased expression of vascular VE-cadherin caused blood vessel impairment, thereby promoting hyperpermeability in various organs. Elevated levels of soluble heparan sulfate, hyaluronic acid and syndecan-1 were measured in blood samples following ricin intoxication, indicating that the vascular glycocalyx of both mice and swine underwent extensive damage. Finally, by using side-stream dark field intravital microscopy imaging, we determined that ricin poisoning leads to microvasculature malfunctioning, as manifested by aberrant blood flow and a significant decrease in the number of diffused microvessels. These findings, which suggest that glycocalyx shedding and microcirculation dysfunction play a major role in the pathology of systemic ricin poisoning, may serve for the formulation of specifically tailored therapies for treating parenteral ricin intoxication.

scholarly journals Abdominal organs' microcirculation dysfunction sequence in severe sepsis by SDF microscopy and histology

Critical Care ◽  
2012 ◽  
Vol 16 (S3) ◽  
Author(s):  
J Almeida-Filho ◽  
AMA Liberatore ◽  
RC Tedesco ◽  
EC Del-Massa ◽  
IHJ Koh
Keyword(s):  
Severe Sepsis ◽  
Abdominal Organs ◽  
Microcirculation Dysfunction
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