scholarly journals The Effect of Endurance Training on Brain-Derived Neurotrophic Factor and Inflammatory Markers in Healthy People and Parkinson's Disease. A Narrative Review

2020 ◽  
Vol 11 ◽  
Author(s):  
Paulina Małczyńska-Sims ◽  
Małgorzata Chalimoniuk ◽  
Anna Sułek
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Endurance Training ◽  
Endurance Exercise ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
The Body ◽  
Narrative Review ◽  
Positive Effects ◽  
Inflammatory Status

Background: One purpose of the training conducted by people is to lose bodyweight and improve their physical condition. It is well-known that endurance training provides many positive changes in the body, not only those associated with current beauty standards. It also promotes biochemical changes such as a decreased inflammatory status, memory improvements through increased brain-derived neurotrophic factor levels, and reduced stress hormone levels. The positive effects of training may provide a novel solution for people with Parkinson's disease, as a way to reduce the inflammatory status and decrease neurodegeneration through stimulation of neuroplasticity and improved motor conditions.Aim: This narrative review aims to focus on the relationship between an acute bout of endurance exercise, endurance training (continuous and interval), brain-derived neurotrophic factor and inflammatory status in the three subject groups (young adults, older adult, and patients with Parkinson's disease), and to review the current state of knowledge about the possible causes of the differences in brain-derived neurotrophic factor and inflammatory status response to a bout of endurance exercise and endurance training. Furthermore, short practical recommendations for PD patients were formulated for improving the efficacy of the training process during rehabilitation.Methods: A narrative review was performed following an electronic search of the database PubMed/Medline and Web of Science for English-language articles between January 2010 and January 2020.Results: Analysis of the available publications with partial results revealed (1) a possible connection between the brain-derived neurotrophic factor level and inflammatory status, and (2) a more beneficial influence of endurance training compared with acute bouts of endurance exercise.Conclusion: Despite the lack of direct evidence, the results from studies show that endurance training may have a positive effect on inflammatory status and brain-derived neurotrophic factor levels. Introducing endurance training as part of the rehabilitation in Parkinson's disease might provide benefits for patients in addition to pharmacological therapy supplementation.

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset

2003 ◽  
Vol 353 (1) ◽  
pp. 75-77 ◽  
Author(s):  
Chen-Jee Hong ◽  
Hsiu-Chih Liu ◽  
Tsung-Yun Liu ◽  
Ching-Hua Lin ◽  
Chih-Ya Cheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurotrophic Factor ◽  
Age Of Onset ◽  
Brain Derived Neurotrophic Factor

scholarly journals Choral singing and emotional communication in people with Parkinson’s disease

2021 ◽  
Author(s):  
Esztella Vezer
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Interpersonal Communication ◽  
Emotion Perception ◽  
The Body ◽  
Motor Functioning ◽  
Facial Mimicry ◽  
Positive Effects ◽  
Vocal Quality ◽  
The Impact

A large part of successful interpersonal communication relies on both the production and interpretation of vocal and facial expressions. Both of these abilities appear to be impaired in people with Parkinson’s disease (PD), a neurodegenerative disease affecting the muscles of the body. Based on positive effects of rhythmic auditory stimulation on overall motor functioning and the effects of intentional simulation of expression on facial mimicry, the present study investigated the impact of a choir program involving singing of happy and sad songs on a group of 12 PD patients. Participants were tested before and after program completion on measures of: (1) facial mimicry of a range of emotional expressions; (2) emotion perception, and; (3) vocal quality. It was found that choir participation improved some measures of vocal quality, while effects on facial mimicry and emotion perception were marginal.

Brain-derived neurotrophic factor G196A polymorphism and clinical features in Parkinson’s disease

2010 ◽  
Vol 122 (1) ◽  
pp. 41-45 ◽  
Author(s):  
L. Gao ◽  
F. J. Díaz-Corrales ◽  
F. Carrillo ◽  
J. Díaz-Martín ◽  
M. T. Caceres-Redondo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Features ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals Plasma Exosomal Brain-Derived Neurotrophic Factor Correlated with the Postural Instability and Gait Disturbance–Related Motor Symptoms in Patients with Parkinson’s Disease

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 684
Author(s):  
Chen Chih Chung ◽  
Pai Hao Huang ◽  
Lung Chan ◽  
Jia-Hung Chen ◽  
Li-Nien Chien ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurotrophic Factor ◽  
Rating Scale ◽  
Brain Derived Neurotrophic Factor ◽  
Postural Instability ◽  
Gait Disturbance ◽  
Enzyme Linked Immunosorbent Assay ◽  
Motor Symptoms ◽  
Bdnf Level

Brain-derived neurotrophic factor (BDNF) is an essential neurotrophin, responsible for neuronal development, function, and survival. Assessments of peripheral blood BDNF in patients with Parkinson’s disease (PD) previously yielded inconsistent results. Plasma exosomes can carry BDNF, so this study investigated the role of plasma exosomal BDNF level as a biomarker of PD. A total of 114 patients with mild to moderate PD and 42 non-PD controls were recruited, and their clinical presentations were evaluated. Plasma exosomes were isolated with exoEasy Maxi Kits, and enzyme-linked immunosorbent assay was used to assess plasma exosomal BDNF levels. Statistical analysis was performed using SPSS version 19.0, and findings were considered significant at p < 0.05. The analysis revealed no significant differences in plasma exosomal BDNF levels between patients with PD and controls. Patients with PD with low plasma exosomal BDNF levels (in the lowest quartile) exhibited a significant association with daily activity dysfunction but not with cognition/mood or overall motor symptoms as assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS). Investigation of UPDRS part III subitems revealed that low plasma exosomal BDNF level was significantly associated with increased motor severity of postural instability and gait disturbance (PIGD)-associated symptoms (rising from a chair, gait, and postural stability) after adjustment for age and sex. In conclusion, although plasma exosomal BDNF level could not distinguish patients with PD from controls, the association with PIGD symptoms in patients with PD may indicate its potential role as a biomarker. Follow-up studies should investigate the association between plasma exosomal BDNF levels and changes in clinical symptoms.

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