scholarly journals Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions

2021 ◽  
Vol 12 ◽  
Author(s):  
Ludmila Kh. Pastushkova ◽  
Vasily B. Rusanov ◽  
Anna G. Goncharova ◽  
Andrei M. Nosovskiy ◽  
Elena S. Luchitskaya ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Blood Plasma ◽  
Plasma Proteins ◽  
Recovery Period ◽  
Space Missions ◽  
Autonomic Regulation ◽  
Type Iv Collagenase ◽  
Concentration Changes ◽  
Blood Plasma Proteins

The study presents the results of evaluating the changes in the concentrations of blood plasma proteins associated with heart rate variability (HRV) in cosmonauts who have completed space missions lasting about 6months. The concentrations of 125 proteins were quantified in biological samples of the cosmonauts’ blood plasma. The subgroups of proteins associated with the physiological processes of the HRV autonomic regulation were identified using bioinformatic resources (Immunoglobulin heavy constant mu, Complement C1q subcomponent subunit C, Plasma serine protease inhibitor, Protein-72kDa type IV collagenase, Fibulin-1, Immunoglobulin lambda constant 3). The concentration of these proteins in the blood plasma before the flight, and the dynamics of concentration changes on the 1st and 7th days of the post-flight rehabilitation period differed in the groups of cosmonauts with a predominance of sympathetic or parasympathetic modulating autonomous influences. The dynamics of changes in the concentrations of the identified set of proteins reveal that in cosmonauts with a predominance of sympathetic modulating influences, the mechanisms of autonomic regulation are exposed to significant stress in the recovery period immediately after the completion of the space mission, compared with the cosmonauts with a predominance of parasympathetic modulating influences.

Post-Translational Oxidation Modifications of Blood Plasma Proteins of Cosmonauts after a Long-term Flight: Part I

2020 ◽  
Vol 46 (5) ◽  
pp. 531-539
Author(s):  
I. M. Larina ◽  
A. G. Brzhzovsky ◽  
A. M. Nosovsky ◽  
A. S. Kononikhin ◽  
O. I. Orlov
Keyword(s):  
Blood Plasma ◽  
Plasma Proteins ◽  
Blood Plasma Proteins

scholarly journals BIOPHYSICAL STUDIES OF BLOOD PLASMA PROTEINS

1946 ◽  
Vol 165 (1) ◽  
pp. 21-35 ◽  
Author(s):  
H.F. Deutsch ◽  
R.A. Alberty ◽  
L.J. Gosting
Keyword(s):  
Blood Plasma ◽  
Plasma Proteins ◽  
Biophysical Studies ◽  
Blood Plasma Proteins

Oxidative and Nitrative Modifications of Blood Plasma Proteins in Patients with Myasthenia Gravis

2016 ◽  
Vol 100 ◽  
pp. S166
Author(s):  
Izabela Sadowska-Bartosz ◽  
Sabina Galiniak ◽  
Grzegorz Bartosz ◽  
Izabela Rozmiłowska ◽  
Damian Czyżewski ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Blood Plasma ◽  
Plasma Proteins ◽  
Blood Plasma Proteins

Feracryl, a new hemostatic polymer, and its interaction with blood plasma proteins

1980 ◽  
Vol 14 (7) ◽  
pp. 431-433 ◽  
Author(s):  
V. Z. Annenkova ◽  
N. G. Dianova ◽  
V. M. Annenkova ◽  
G. S. Ugryumova ◽  
M. G. Voronkov
Keyword(s):  
Blood Plasma ◽  
Plasma Proteins ◽  
Blood Plasma Proteins

scholarly journals Features of heart rate variability in patients with takotsubo syndrome

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
D Evdokimov ◽  
SA Boldueva ◽  
VS Feoktistova ◽  
TA Baeva
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sinus Rhythm ◽  
Autonomic Regulation ◽  
Deep Breathing ◽  
Takotsubo Syndrome ◽  
Orthostatic Test ◽  
Rate Regulation ◽  
Heart Rate Regulation ◽  
Deep Breathing Test

Abstract Funding Acknowledgements Type of funding sources: None. Main funding source(s): North-Western State Medical University named after I.I. Mechnikov Objective to study the features of autonomic regulation of sinus rhythm features of autonomic regulation of cardiac sinus rhythm in patients with Takotsubo syndrome (TTS) during inpatient stay in hospital. Materials and methods. The study included 25 female patients (the median age 57.5 ± 28.5 years) with TTS, diagnosis was based on the InterTAK criteria. On the 5-7th day after admission, the heart rate variability (HRV) was assessed both at rest and cardiac autonomic function tests: the deep breathing test (DBT) and active orthostatic test (AOT) with the usage of a computer diagnostic system «Valenta». RESULTS According to HRV data, initially at rest, the majority of the studied patients predominantly had a parasympathetic impact on the heart rate regulation: in 70% - increased parasympathetic influence, in 17% - increased sympathetic influence, in 13% - a balanced heart rate regulation. When performing a DBT, the predominance of the parasympathetic influence on the heart rate was noted both in spectral parameters and according to the data of time analysis (HF  during DBT  increased 1.8 times  up to  489.6 ± 114.2 ms2 (p <0.05) ; LF  decreased 1.7 times  up to 254.1 ± 70.3 ms2 (p <0.05); VLF  increased 2.8 times up to 402.3 ± 101.8 ms2 (p <0, 05); TP  increased 1.4 times up to 1145.9 ± 251.3 ms2; CV increased 1.3 times up to 6.5 ± 0.7% (p <0.05); SDNN increased 1.3 times up to - 58.7 ± 6.6 ms (p <0.05). HRV measured during an AOT  showed a paradoxical  evaluation  in the parasympathetic impact on the heart rate (HF increased by 1.8 times and reached - 488.0 ± 104.7 ms2 (p <0.05); LF decreased by 1.1 times up to  408 , 4 ± 103.6 ms2; VLF increased 1.2 times  up to  166.4 ± 52.2 ms2; TP increased 1.3 times  up to 1062.8 ± 181.1 ms2 (p <0.05); CV increased 1.6 times  up to 8.0 ± 0.9% (p <0.05); SDNN increased 1.4 times  up to 62.6 ± 7.5 ms (p <0.05)). Conclusions During the index hospital inpatient stays the majority of patients with TTS have a vegetative imbalance due to increased parasympathetic influence on the heart rate, both at rest and  during a deep breathing test and an active orthostatic test. This fact is quite unexpected and requires further study.

Quantitative target proteomics of chromosome 13 human blood plasma proteins

2017 ◽  
Vol 476 (1) ◽  
pp. 326-328 ◽  
Author(s):  
A. T. Kopylov ◽  
E. V. Ilgisonis ◽  
O. V. Tikhonova ◽  
T. E. Farafonova ◽  
S. E. Novikova ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Plasma Proteins ◽  
Human Blood Plasma ◽  
Chromosome 13 ◽  
Blood Plasma Proteins

scholarly journals Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis

2018 ◽  
Vol 104 (2) ◽  
pp. 171-181 ◽  
Author(s):  
Xiao Liang ◽  
Yanan Du ◽  
Yan Wen ◽  
Li Liu ◽  
Ping Li ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Risk Score ◽  
Plasma Proteins ◽  
Genetic Correlations ◽  
Polygenic Risk Score ◽  
Polygenic Risk ◽  
Score Analysis ◽  
Blood Plasma Proteins
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