scholarly journals A Review of the Challenge-Hindrance Stress Model: Recent Advances, Expanded Paradigms, and Recommendations for Future Research

2020 ◽  
Vol 11 ◽  
Author(s):  
Kristin A. Horan ◽  
Wheeler H. Nakahara ◽  
Michael J. DiStaso ◽  
Steve M. Jex
Keyword(s):  
Future Research ◽  
Stress Model ◽  
Recent Advances ◽  
Hindrance Stress

scholarly journals Molecular biology of potexviruses: recent advances

2007 ◽  
Vol 88 (6) ◽  
pp. 1643-1655 ◽  
Author(s):  
Jeanmarie Verchot-Lubicz ◽  
Chang-Ming Ye ◽  
Devinka Bamunusinghe
Keyword(s):  
Gene Silencing ◽  
Rna Synthesis ◽  
Triple Gene Block ◽  
Potato Virus X ◽  
Future Research ◽  
Virus Movement ◽  
Suppressor Activity ◽  
Gene Block ◽  
Recent Advances

Recent advances in potexvirus research have produced new models describing virus replication, cell-to-cell movement, encapsidation, R gene-mediated resistance and gene silencing. Interactions between distant RNA elements are a central theme in potexvirus replication. The 5′ non-translated region (NTR) regulates genomic and subgenomic RNA synthesis and encapsidation, as well as virus plasmodesmal transport. The 3′ NTR regulates both plus- and minus-strand RNA synthesis. How the triple gene-block proteins interact for virus movement is still elusive. As the potato virus X (PVX) TGBp1 protein gates plasmodesmata, regulates virus translation and is a suppressor of RNA silencing, further research is needed to determine how these properties contribute to propelling virus through the plasmodesmata. Specifically, TGBp1 suppressor activity is required for virus movement, but how the silencing machinery relates to plasmodesmata is not known. The TGBp2 and TGBp3 proteins are endoplasmic reticulum (ER)-associated proteins required for virus movement. TGBp2 associates with ER-derived vesicles that traffic along the actin network. Future research will determine whether the virus-induced vesicles are cytopathic structures regulating events along the ER or are vehicles carrying virus to the plasmodesmata for transfer into neighbouring cells. Efforts to assemble virions in vitro identified a single-tailed particle (STP) comprising RNA, coat protein (CP) and TGBp1. It has been proposed that TGBp1 aids in transport of virions or STP between cells and ensures translation of RNA in the receiving cells. PVX is also a tool for studying Avr–R gene interactions and gene silencing in plants. The PVX CP is the elicitor for the Rx gene. Recent reports of the PVX CP reveal how CP interacts with the Rx gene product.

Landscape Models of Complex Change

2021 ◽  
pp. 554-580
Author(s):  
Daniel Albert ◽  
Martin Ganco
Keyword(s):  
Organizational Change ◽  
Future Research ◽  
Research Directions ◽  
Traditional Form ◽  
Nk Model ◽  
Complex Change ◽  
Landscape Models ◽  
Recent Advances ◽  
Complex Landscape ◽  
Future Research Directions

This chapter reviews recent advances in the NK modeling literature conceptualizing organizational change and innovation as a search over a complex landscape. It discusses both strengths and limitations of this perspective and delineates potential for future research directions. The key argument is that the NK model in its traditional form may be exhausting the theoretical insights that it can provide to the field. However, substantial modifications and extensions of the NK model or new classes of landscape models may provide fresh perspectives. Specifically, we consider the modeling efforts that endogenize the landscape construction as the next frontier in this literature. We also discuss several recent studies that incorporate various extensions of the NK model and allow for agent-driven changes to the landscape.

Blockchain for Digital Twins: Recent Advances and Future Research Challenges

IEEE Network ◽  
2020 ◽  
Vol 34 (5) ◽  
pp. 290-298 ◽  
Author(s):  
Ibrar Yaqoob ◽  
Khaled Salah ◽  
Mueen Uddin ◽  
Raja Jayaraman ◽  
Mohammed Omar ◽  
...  
Keyword(s):  
Future Research ◽  
Research Challenges ◽  
Recent Advances ◽  
Digital Twins

scholarly journals CubeSat Communications: Recent Advances and Future Challenges

2020 ◽  
Author(s):  
Nasir Saeed ◽  
Ahmed Elzanaty ◽  
Heba Almorad ◽  
Hayssam Dahrouj ◽  
Tareq Y. Al-Naffouri ◽  
...  
Keyword(s):  
Channel Modeling ◽  
Future Research ◽  
New Paradigm ◽  
Earth Remote Sensing ◽  
Research Directions ◽  
Space Industry ◽  
Recent Advances ◽  
Wide Range ◽  
Future Challenges ◽  
Future Research Directions

<pre><pre>Given the increasing number of space-related applications, research in the emerging space industry is becoming more and more attractive. One compelling area of current space research is the design of miniaturized satellites, known as CubeSats, which are enticing because of their numerous applications and low design-and-deployment cost. </pre><pre>The new paradigm of connected space through CubeSats makes possible a wide range of applications, such as Earth remote sensing, space exploration, and rural connectivity.</pre><pre>CubeSats further provide a complementary connectivity solution to the pervasive Internet of Things (IoT) networks, leading to a globally connected cyber-physical system.</pre><pre>This paper presents a holistic overview of various aspects of CubeSat missions and provides a thorough review of the topic from both academic and industrial perspectives.</pre><pre>We further present recent advances in the area of CubeSat communications, with an emphasis on constellation-and-coverage issues, channel modeling, modulation and coding, and networking.</pre><pre>Finally, we identify several future research directions for CubeSat communications, including Internet of space things, low-power long-range networks, and machine learning for CubeSat resource allocation.</pre></pre>

Novel avenues to approach non-CPAP therapy and implement comprehensive OSA care

2021 ◽  
pp. 2101788
Author(s):  
Jean-Louis Pépin ◽  
Peter Eastwood ◽  
Danny J. Eckert
Keyword(s):  
Treatment Success ◽  
Clinical Manifestations ◽  
Upper Airway ◽  
Sleep Apnoea ◽  
Mandibular Advancement ◽  
Individual Risk ◽  
Future Research ◽  
Success Rates ◽  
Recent Advances ◽  
Obstructive Sleep

Recent advances in obstructive sleep apnoea (OSA) pathophysiology and translational research have opened new lines of investigation for OSA treatment and management. Key goals of such investigations are to provide efficacious, alternative treatment and management pathways that are better tailored to individual risk profiles to move beyond the traditional, continuous positive airway pressure (CPAP)-focused, “one size fits all”, trial and error approach which is too frequently inadequate for many patients. Identification of different clinical manifestations of OSA (clinical phenotypes) and underlying pathophysiological phenotypes (endotypes), that contribute to OSA have provided novel insights into underlying mechanisms and have underpinned these efforts. Indeed, this new knowledge has provided the framework for precision medicine for OSA to improve treatment success rates with existing non-CPAP therapies such as mandibular advancement devices and upper airway surgery, and newly developed therapies such as hypoglossal nerve stimulation and emerging therapies such as pharmacotherapies and combination therapy. These concepts have also provided insight into potential physiological barriers to CPAP adherence for certain patients. This review summarises the recent advances in OSA pathogenesis, non-CPAP treatment, clinical management approaches and highlights knowledge gaps for future research. OSA endotyping and clinical phenotyping, risk stratification and personalised treatment allocation approaches are rapidly evolving and will further benefit from the support of recent advances in e-health and artificial intelligence.

scholarly journals Recent advances in amniote palaeocolour reconstruction and a framework for future research

2019 ◽  
Vol 95 (1) ◽  
pp. 22-50 ◽  
Author(s):  
Arindam Roy ◽  
Michael Pittman ◽  
Evan T. Saitta ◽  
Thomas G. Kaye ◽  
Xing Xu
Keyword(s):  
Future Research ◽  
Recent Advances

Recent advances in supramolecular block copolymers for biomedical applications

2020 ◽  
Vol 8 (36) ◽  
pp. 8219-8231
Author(s):  
Wumaier Yasen ◽  
Ruijiao Dong ◽  
Aliya Aini ◽  
Xinyuan Zhu
Keyword(s):  
Block Copolymers ◽  
Biomedical Applications ◽  
Future Research ◽  
Biological Applications ◽  
Research Directions ◽  
Recent Advances ◽  
Future Research Directions ◽  
Reversible Nature

Supramolecular block copolymers with a dynamically reversible nature and hierarchical microphase-separated structures can greatly enrich the library of pharmaceutical carriers and outline future research directions for biological applications.

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