Rapid Eye Movement Sleep, Sleep Continuity and Slow Wave Sleep as Predictors of Cognition, Mood, and Subjective Sleep Quality in Healthy Men and Women, Aged 20–84 Years

Background:Sleep disorders are widespread among patients with schizophrenia and contribute to adverse clinical outcomes. Antipsychotic drugs exert varying effects on sleep, and the effects of atypical agents may differ from those of conventional neuroleptics.Objective:To review the literature on the effects of atypical medication on subjective and objective sleep quality in patients with schizophrenia.Methods:A non-systematic literature review of Medline was performed in August 2003 searching the period from January 1985 to August 2003 for studies of the effects of atypical antipsychotics on sleep.Results:We found published studies of clozapine, olanzapine, and risperidone, but none on quetiapine or ziprasidone. Studies with clozapine showed that it increased total sleep time, sleep efficiency, stage-2 non-rapid eye movement sleep and rapid eye movement (REM) sleep density, and decreased stage-4 sleep, slow wave sleep (SWS) and stage-1 sleep. Single-dose studies with olanzapine have shown that it increases SWS, sleep continuity, total sleeping time, subjective sleep quality, and delta sleep. Long-term studies with risperidone have shown improvements in total sleep, sleep efficiency, sleep continuity, SWS, and stage-2 sleep, and reductions in sleep latency, number of awakenings, and proportion of time awake. These benefits were paralleled by improvements in subjective sleep assessment and psychopathology, and psychosocial functioning.Conclusions:The evidence presented in this review suggests that atypical antipsychotics exert favorable effects on sleep profile compared with conventional agents, including improvement of subjective sleep quality and modification of specific sleep stages known to be associated with better clinical outcome.

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0337 Effects of Slow Wave Sleep Augmentation on Subjective Sleep Quality

SLEEP ◽

10.1093/sleep/zsy061.336 ◽

2018 ◽

Vol 41 (suppl_1) ◽

pp. A129-A129

Author(s):

M L Lamphere ◽

C S Robinson ◽

N B Bryant ◽

A P Jones ◽

B Robert ◽

...

Keyword(s):

Sleep Quality ◽

Slow Wave ◽

Slow Wave Sleep ◽

Subjective Sleep Quality ◽

Subjective Sleep

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Effects of sleep-promoting factor from human urine on sleep cycle of cats

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1981.241.4.e269 ◽

1981 ◽

Vol 241 (4) ◽

pp. E269-E274

Author(s):

J. E. Garcia-Arraras

Keyword(s):

Cerebrospinal Fluid ◽

Eye Movement ◽

Slow Wave ◽

Human Urine ◽

Slow Wave Sleep ◽

Sleep Cycle ◽

Rapid Eye Movement ◽

Rapid Eye Movement Sleep ◽

Artificial Cerebrospinal Fluid ◽

Normal Sleep

Slow-wave sleep (SWS) and rapid-eye-movement sleep (REM) were recorded in cats for 32 h a) under control conditions, b) following intraventricular infusions of artificial cerebrospinal fluid (CSF), and c) following infusions of sleep-promoting factor S prepared from human urine (SPU). During the first 12 h after receiving artificial CSF, the cats slept 4.9 +/- 0.2 h in slow-wave sleep (SWS) and 1.4 +/- 0.1 h in REM. Similar values were obtained from the same cats under control conditions. After infusions of SPU, the duration of SWS in the same cats increased to an average of 6.9 +/- 0.5 h with no significant change in REM averaged over 12 h; a transient decrease of REM in the first 4 h was fully compensated in subsequent hours. The increased SWS induced by the sleep-promoting factor from human urine subsided after 12 h, and there was no compensatory increase in wakefulness during the subsequent 20 h. The normal sleep cycle was not affected. In cats, therefore, the primary effect of SPU is to increase normal SWS, with little effect on REM.

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The dream-lag effect: Selective processing of personally significant events during Rapid Eye Movement sleep, but not during Slow Wave Sleep

Neurobiology of Learning and Memory ◽

10.1016/j.nlm.2015.01.009 ◽

2015 ◽

Vol 122 ◽

pp. 98-109 ◽

Cited By ~ 36

Author(s):

E. van Rijn ◽

J.-B. Eichenlaub ◽

P.A. Lewis ◽

M.P. Walker ◽

M.G. Gaskell ◽

...

Keyword(s):

Eye Movement ◽

Slow Wave ◽

Slow Wave Sleep ◽

Rapid Eye Movement ◽

Rapid Eye Movement Sleep ◽

Significant Events ◽

Lag Effect ◽

Selective Processing

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Changes in Emotional Responses to Aversive Pictures Across Periods Rich in Slow-Wave Sleep Versus Rapid Eye Movement Sleep

Psychosomatic Medicine ◽

10.1097/00006842-200207000-00013 ◽

2002 ◽

Vol 64 (4) ◽

pp. 627-634 ◽

Cited By ~ 3

Author(s):

Ullrich Wagner ◽

Stefan Fischer ◽

Jan Born

Keyword(s):

Eye Movement ◽

Slow Wave ◽

Slow Wave Sleep ◽

Emotional Responses ◽

Rapid Eye Movement ◽

Rapid Eye Movement Sleep

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The Benefits of Closed-Loop Transcranial Alternating Current Stimulation on Subjective Sleep Quality

Brain Sciences ◽

10.3390/brainsci8120204 ◽

2018 ◽

Vol 8 (12) ◽

pp. 204 ◽

Cited By ~ 6

Author(s):

Charles Robinson ◽

Natalie Bryant ◽

Joshua Maxwell ◽

Aaron Jones ◽

Bradley Robert ◽

...

Keyword(s):

Sleep Quality ◽

Slow Wave ◽

Closed Loop ◽

Slow Wave Sleep ◽

The United States ◽

Alternating Current ◽

Poor Sleep ◽

Subjective Sleep Quality ◽

Subjective Sleep ◽

Transcranial Alternating Current Stimulation

Background: Poor sleep quality is a common complaint, affecting over one third of people in the United States. While sleep quality is thought to be related to slow-wave sleep (SWS), there has been little investigation to address whether modulating slow-wave oscillations (SWOs) that characterize SWS could impact sleep quality. Here we examined whether closed-loop transcranial alternating current stimulation (CL-tACS) applied during sleep impacts sleep quality and efficiency. Methods: CL-tACS was used in 21 participants delivered at the same frequency and in phase with endogenous SWOs during sleep. Sleep quality was assessed in the morning following either verum or sham control stimulation during sleep, with order counterbalanced within participants. Results: Higher sleep quality and efficiency were found after verum stimulation nights compared to control. The largest effects on sleep quality were found immediately following an adaptation night in the laboratory for which sleep quality was reduced. Conclusions: Applying CL-tACS at the same frequency and phase as endogenous SWOs may offer a novel method to improve subjective sleep quality after a night with poor quality sleep. CL-tACS might be helpful for increasing sleep quality and efficiency in otherwise healthy people, and in patients with clinical disorders that involve sleep deficits.

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