scholarly journals Anxiety Is Associated With DPPIV Alterations in Children With Selective Mutism and Social Anxiety Disorder: A Pilot Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Yulia Golub ◽  
Valeska Stonawski ◽  
Anne C. Plank ◽  
Anna Eichler ◽  
Oliver Kratz ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Pilot Study ◽  
Social Anxiety ◽  
Social Anxiety Disorder ◽  
Selective Mutism ◽  
Control Group ◽  
Dipeptidyl Peptidase 4 ◽  
Adolescent Anxiety ◽  
Pediatric Anxiety Disorders ◽  
Underlying Mechanisms

Background: Both selective mutism (SM) and social anxiety disorder (SAD) are severe pediatric anxiety disorders with the common trait of behavioral inhibition (BI). The underlying pathophysiology of these disorders remains poorly understood, however converging evidence suggests that alterations in several peripheral molecular pathways might be involved. In a pilot study, we investigated alterations in plasma molecular markers (dipeptidyl peptidase-4 [DPPIV], interleukin-6 [IL-6], tumor necrosis factor-β [TNF-β] and neuropeptide-Y [NPY]) in children with SM, SAD, and healthy controls, as well as the correlation of these markers to symptom severity.Methods: We included 51 children and adolescents (aged 5–18 years; n = 29 girls): n = 20 children in the SM-, n = 16 in the SAD- and n = 15 in the control-group (CG). Peripheral blood samples were analyzed for DPPIV, IL-6, TNF-β, and NPY concentrations. Diverse psychometric measures were used for BI, anxiety, and mutism symptoms.Results: Lower DPPIV-levels were correlated with more anxiety symptoms. However, we could not find a difference in any molecular marker between the patients with SAD and SM in comparison to the CG.Conclusion: DPPIV is proposed as relevant marker for child and adolescent anxiety. Investigating the pathophysiology of SM and SAD focusing on state and trait variables as anxiety or BI might help better understanding the underlying mechanisms of these disorders. Further studies with especially larger cohorts are needed to validate the current pilot-findings.

scholarly journals The Effects of Approach–Avoidance Modification on Social Anxiety Disorder: A Pilot Study

2013 ◽  
Vol 38 (2) ◽  
pp. 226-238 ◽  
Author(s):  
Anu Asnaani ◽  
Mike Rinck ◽  
Eni Becker ◽  
Stefan G. Hofmann
Keyword(s):  
Anxiety Disorder ◽  
Pilot Study ◽  
Social Anxiety ◽  
Social Anxiety Disorder ◽  
Approach Avoidance

Citalopram for Social Anxiety Disorder: An Open-label Pilot Study in Refractory and Nonrefractory Patients

CNS Spectrums ◽  
2002 ◽  
Vol 7 (9) ◽  
pp. 655-657 ◽  
Author(s):  
Naomi M. Simon ◽  
Nicole B. Korbly ◽  
John J. Worthington ◽  
Gustavo Kinrys ◽  
Mark H. Pollack
Keyword(s):  
Anxiety Disorder ◽  
Pilot Study ◽  
Social Anxiety ◽  
Social Anxiety Disorder ◽  
Prior Treatment ◽  
Treatment Intervention ◽  
Treatment Trial ◽  
Open Label ◽  
Systematic Data ◽  
Open Label Trial

ABSTRACTThere is limited systematic data assessing alternate pharmacotherapy of social anxiety disorder in patients failing to tolerate or fully respond to initial treatment; no data specifically address the efficacy of citalopram in this scenario. We present a prospective open-label trial of citalopram in 10 patients with generalized social anxiety disorder, 6 of 10 of whom had not responded to or not tolerated a prior treatment intervention for the disorder. Citalopram, at a mean dose of 55 mg (SD+12.7 mg) was well tolerated, and patients improved significantly on all outcome measures. Results of this study suggest that citalopram may be a safe and effective treatment for generalized social anxiety disorder, including patients who have failed to tolerate or respond to a prior treatment trial.

scholarly journals SOCIAL ANXIETY DISORDER RATIO AND SOME RELATED FACTORS IN THE STUDENT OF NGUYEN KHUYEN HIGH SCHOOL, BINH PHUOC

2021 ◽  
Vol 62 (4) ◽  
Author(s):  
Le Thi Diem Trinh ◽  
Pham Tuan Cuong ◽  
Nguyen Ngoc Bich ◽  
Nguyen Duy Phong
Keyword(s):  
High School ◽  
Anxiety Disorder ◽  
Social Anxiety ◽  
Early Detection ◽  
Social Anxiety Disorder ◽  
Significant Relationship ◽  
Related Factors ◽  
Adolescent Anxiety ◽  
School Work ◽  
The World

Social anxiety disorder is a common adolescent anxiety disorder with rates ranging from 9.1% to 44%between countries around the world. In Vietnam, research on this disorder is quite limited. Socialphobia affects many aspects of life, such as school, work, and increases the risk of depression andsuicide in adults. However, finding treatment, the recovery rate is still quite low. So early screeningfor this disorder is necessary. The study conducted on 430 students participating in the study, theprevalence of phobias on the LSAS scale was 42.3%. 35.7% and 37.4% respectively. Multivariateanalysis showed a statistically significant relationship between social phobia and factors such aslack of confidence in appearance, mother’s occupation (p <0.05). Research has given a numberof recommendations for early detection and timely intervention solutions towards comprehensivehealth care for students

scholarly journals Social anxiety disorder and emotion regulation problems in adolescents

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Petra Sackl-Pammer ◽  
Rebecca Jahn ◽  
Zeliha Özlü-Erkilic ◽  
Eva Pollak ◽  
Susanne Ohmann ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Anxiety Disorder ◽  
Social Anxiety ◽  
Social Anxiety Disorder ◽  
Behavioral Therapy ◽  
Group Differences ◽  
Control Group ◽  
Central Component ◽  
Therapy Process ◽  
Regulation Strategies

Abstract Background Social anxiety disorder (SAD) in adolescents may be associated with the use of maladaptive emotion regulation (ER) strategies. The present study examined the use of maladaptive and adaptive ER strategies in adolescents with SAD. Methods 30 adolescents with SAD (CLIN) and 36 healthy adolescents for the control group (CON) aged between 11 and 16 years were assessed with the standardized questionnaires PHOKI (Phobiefragebogen für Kinder und Jugendliche) for self-reported fears as well as FEEL-KJ (Fragebogen zur Erhebung der Emotionsregulation bei Kindern und Jugendlichen) for different emotion regulation strategies. Results Compared to controls, adolescents with SAD used adaptive ER strategies significantly less often, but made use of maladaptive ER strategies significantly more often. There was a significant positive correlation between maladaptive ER and social anxiety in adolescents. Examining group differences of single ER strategy use, the CLIN and CON differed significantly in the use of the adaptive ER strategy reappraisal with CLIN reporting less use of reappraisal than CON. Group differences regarding the maladaptive ER strategies withdrawal and rumination, as well as the adaptive ER strategy problem-solving were found present, with CLIN reporting more use of withdrawal and rumination and less use of problem-solving than CON. Conclusions Promoting adaptive emotion regulation should be a central component of psychotherapy (cognitive behavioral therapy-CBT) for social anxiety in adolescents from the beginning of the therapy process. These findings provide rationale for special therapy programs concentrating on the establishment of different adaptive ER strategies (including reappraisal). As an increased use of maladaptive ER may be associated with SAD in adolescents, it may be paramount to focus on reduction of maladaptive ER (for example withdrawal and rumination) from the beginning of the psychotherapy process. Incorporating more ER components into psychotherapy (CBT) could increase the treatment efficacy. Further investigations of the patterns of emotion regulation in specific anxiety groups like SAD in adolescents is needed to continue to optimize the psychotherapy (CBT) concept.

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