Why Do Animals Get Old and Die?

Frontiers for Young Minds ◽

10.3389/frym.2021.530721 ◽

2021 ◽

Vol 9 ◽

Author(s):

André C. R. Martins ◽

Josh Mitteldorf

Keyword(s):

Animal Species ◽

Living Tissues ◽

Important Purpose ◽

Changing World

As we get old, we become weaker and more vulnerable to diseases. Sooner or later, our health fails, and we die. That happens to most, but not all, animal species. If we want to live longer, understanding why we get weaker is important. Many people work on the question of how aging happens. That is, they try to understand how the cells and living tissues behave as they get older. But there is a deeper question: why do humans and other animals get old at all? Do our bodies just wear out, like old machines? Or is there an important evolutionary reason for getting old? In this article, we will explore those questions. We suggest that getting old and dying serves an important purpose: when the old die, the young can adapt faster to a changing world.

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Animal models of amblyopia

Visual Neuroscience ◽

10.1017/s0952523817000244 ◽

2018 ◽

Vol 35 ◽

Cited By ~ 6

Author(s):

DONALD MITCHELL ◽

FRANK SENGPIEL

Keyword(s):

Clinical Trials ◽

Animal Models ◽

Animal Species ◽

Future Research ◽

Human Interventions ◽

Different Types ◽

Minimum Number ◽

The Many ◽

Degree Of Similarity ◽

Important Purpose

AbstractUnquestionably, the last six decades of research on various animal models have advanced our understanding of the mechanisms that underlie the many complex characteristics of amblyopia as well as provided promising new avenues for treatment. While animal models in general have served an important purpose, there nonetheless remain questions regarding the efficacy of particular models considering the differences across animal species, especially when the goal is to provide the foundations for human interventions. Our discussion of these issues culminated in three recommendations for future research to provide cohesion across animals models as well as a fourth recommendation for acceptance of a protocol for the minimum number of steps necessary for the translation of results obtained on particular animal models to human clinical trials. The three recommendations for future research arose from discussions of various issues including the specific results obtained from the use of different animal models, the degree of similarity to the human visual system, the ability to generate animal models of the different types of human amblyopia as well as the difficulty of scaling developmental timelines between different species.

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Author response for "Perceptual rivalry across animal species"

10.1002/cne.24939/v3/response1 ◽

2020 ◽

Author(s):

Olivia Carter ◽

Bruno Swinderen ◽

David Leopold ◽

Shaun Collin ◽

Alex Maier

Keyword(s):

Animal Species ◽

Author Response ◽

Perceptual Rivalry

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Anchoring Fibrils in Arterial Endothelium

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100063287 ◽

1969 ◽

Vol 27 ◽

pp. 274-275

Author(s):

A. Trillo

Keyword(s):

Carotid Arteries ◽

Animal Species ◽

Cell Layer ◽

Present Communication ◽

Internal Elastic Lamina ◽

Endothelial Cell Layer ◽

Structural Details ◽

Rats And Mice ◽

Arterial Endothelium ◽

Elastic Lamina

There are conflicting reports regarding some fine structural details of arteries from several animal species. Buck denied the existence of a sub-endothelial space, while Karrer and Keech described a space of variable width which separates the endothelium from the underlying internal elastic lamina in aortas of aging rats and mice respectively.The present communication deals with the ultrastrueture of the interface between the endothelial cell layer and the internal elastic lamina as observed in carotid arteries from rabbits of varying ages.

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Ultrastructure and Drug Metabolism in the Developing Guinea Pig

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100073131 ◽

1973 ◽

Vol 31 ◽

pp. 538-539

Author(s):

W. Kuenzig ◽

M. Boublik ◽

J.J. Kamm ◽

J.J. Burns

Keyword(s):

Guinea Pig ◽

Metabolic Activity ◽

Animal Species ◽

Adult Animal ◽

Smooth Endoplasmic Reticulum ◽

Fetal Life ◽

Mixed Function Oxidase ◽

Cytochrome P 450 ◽

Microsomal Mixed Function Oxidase ◽

Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

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Further Studies on the Ultrastructure of Harderian Gland in Adult Rats

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100051451 ◽

1974 ◽

Vol 32 ◽

pp. 288-289

Author(s):

Alfredo Feria-Velasco ◽

Guadalupe Tapia-Arizmendi

Keyword(s):

Fine Structure ◽

Domestic Fowl ◽

Animal Species ◽

Acinar Cells ◽

Harderian Gland ◽

Myoepithelial Cells ◽

The Other ◽

Albino Rats ◽

Adult Rats ◽

Cell Components

The fine structure of the Harderian gland has been described in some animal species (hamster, rabbit, mouse, domestic fowl and albino rats). There are only two reports in the literature dealing on the ultrastructure of rat Harderian gland in adult animals. In one of them the author describes the myoepithelial cells in methacrylate-embbeded tissue, and the other deals with the maturation of the acinar cells and the formation of the secretory droplets. The aim of the present work is to analize the relationships among the acinar cell components and to describe the two types of cells located at the perifery of the acini.

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Low-voltage field-emission SEM of polymeric membranes for glucose biosensors

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100161862 ◽

1990 ◽

Vol 48 (3) ◽

pp. 860-861

Author(s):

Lorna K. Mayo ◽

Kenneth C. Moore ◽

Mark A. Arnold

Keyword(s):

Glucose Sensor ◽

Low Voltage ◽

Glucose Sensors ◽

Polymeric Membranes ◽

Artificial Endocrine Pancreas ◽

Self Monitoring ◽

Conducting Materials ◽

Insulin Dependent ◽

Living Tissues ◽

Voltage Scanning

An implantable artificial endocrine pancreas consisting of a glucose sensor and a closed-loop insulin delivery system could potentially replace the need for glucose self-monitoring and regulation among insulin dependent diabetics. Achieving such a break through largely depends on the development of an appropriate, biocompatible membrane for the sensor. Biocompatibility is crucial since changes in the glucose sensors membrane resulting from attack by orinter action with living tissues can interfere with sensor reliability and accuracy. If such interactions can be understood, however, compensations can be made for their effects. Current polymer technology offers several possible membranes that meet the unique chemical dynamics required of a glucose sensor. Two of the most promising polymer membranes are polytetrafluoroethylene (PTFE) and silicone (Si). Low-voltage scanning electron microscopy, which is an excellent technique for characterizing a variety of polymeric and non-conducting materials, 27 was applied to the examination of experimental sensor membranes.

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The Contribution of Pavlov's Typology of CNS Properties to Personality Research

European Psychologist ◽

10.1027/1016-9040.2.2.125 ◽

1997 ◽

Vol 2 (2) ◽

pp. 125-138 ◽

Cited By ~ 17

Author(s):

Jan Strelau

Keyword(s):

Soviet Union ◽

Former Soviet Union ◽

Animal Species ◽

Special Significance ◽

The West ◽

Personality Dimensions ◽

Personality Research ◽

Personality Theories ◽

Strength Of Excitation ◽

Point Of Departure

This paper presents Pavlov's contribution to the development of biological-oriented personality theories. Taking a short description of Pavlov's typology of central nervous system (CNS) properties as a point of departure, it shows how, and to what extent, this typology influenced further research in the former Soviet Union as well as in the West. Of special significance for the development of biologically oriented personality dimensions was the conditioned reflex paradigm introduced by Pavlov for studying individual differences in dogs. This paradigm was used by Russian psychologists in research on types of nervous systems conducted in different animal species as well as for assessing temperament in children and adults. Also, personality psychologists in the West, such as Eysenck, Spence, and Gray, incorporated the CR paradigm into their theories. Among the basic properties of excitation and inhibition on which Pavlov's typology was based, strength of excitation and the basic indicator of this property, protective inhibition, gained the highest popularity in arousaloriented personality theories. Many studies have been conducted in which the Pavlovian constructs of CNS properties have been related to different personality dimensions. In current research the behavioral expressions of the Pavlovian constructs of strength of excitation, strength of inhibition, and mobility of nervous processes as measured by the Pavlovian Temperament Survey (PTS) have been related to over a dozen of personality dimensions, mostly referring to temperament.

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Animals as Social Objects

European Psychologist ◽

10.1027/1016-9040/a000268 ◽

2016 ◽

Vol 21 (3) ◽

pp. 206-217 ◽

Cited By ~ 10

Author(s):

Verónica Sevillano ◽

Susan T. Fiske

Keyword(s):

Social Perception ◽

Animal Species ◽

Social Groups ◽

Social Responses ◽

Content Model ◽

Stereotype Content ◽

Nonhuman Animals ◽

Behavioral Tendencies ◽

Similarities And Differences ◽

Sphere Of Influence

Abstract. Nonhuman animals are typically excluded from the scope of social psychology. This article presents animals as social objects – targets of human social responses – overviewing the similarities and differences with human targets. The focus here is on perceiving animal species as social groups. Reflecting the two fundamental dimensions of humans’ social cognition – perceived warmth (benign or ill intent) and competence (high or low ability), proposed within the Stereotype Content Model ( Fiske, Cuddy, Glick, & Xu, 2002 ) – animal stereotypes are identified, together with associated prejudices and behavioral tendencies. In line with human intergroup threats, both realistic and symbolic threats associated with animals are reviewed. As a whole, animals appear to be social perception targets within the human sphere of influence and a valid topic for research.

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