Treatment of Recurrent Undifferentiated Pleomorphic Sarcoma of Infratemporal Fossa by Surgery Combined With Carbon Ion Radiotherapy: One Case Report

We retrospectively analyzed the diagnosis and treatment process of one patient with recurrent undifferentiated pleomorphic sarcoma (UPS) of infratemporal fossa and made a definite diagnosis by combining the imaging and pathological examination results. After treatment failure with 2 cycles of chemotherapy and several surgeries, UPS was eventually treated by surgery + carbon ion radiotherapy, and MRI reexamination showed no relapse. Head and neck UPS is located deeply, easily recurs after operation, and difficult to be resected completely by surgery, with a gradually shortened interval of relapse over the number of surgeries, which becomes a treatment challenge. After the last surgery, the patient received carbon ion radiotherapy, with a good therapeutic effect, and no sign of relapse just before sending this article. Based on the above advantages, we have concluded that surgery + carbon ion radiotherapy is a new effective pathway to treat head and neck UPS.

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EP-1189 Adenoid Cystic Carcinoma Of The Head And Neck Treated With Carbon Ion Radiotherapy At CNAO

Radiotherapy and Oncology ◽

10.1016/s0167-8140(19)31609-3 ◽

2019 ◽

Vol 133 ◽

pp. S659

Author(s):

M. Bonora ◽

B. Vischioni ◽

D. Caivano ◽

A. Hasegawa ◽

V. Vitolo ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Head And Neck ◽

Carbon Ion Radiotherapy ◽

Carbon Ion ◽

Adenoid Cystic

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Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck

Diagnostics ◽

10.3390/diagnostics10020082 ◽

2020 ◽

Vol 10 (2) ◽

pp. 82

Author(s):

Hidenori Suzuki ◽

Eiichi Sasaki ◽

Risa Motai ◽

Seiya Goto ◽

Daisuke Nishikawa ◽

...

Keyword(s):

Malignant Melanoma ◽

Head And Neck ◽

Neck Dissection ◽

Initial Treatment ◽

Concurrent Chemotherapy ◽

Carbon Ion Radiotherapy ◽

Safety And Efficacy ◽

Carbon Ion ◽

Mucosal Malignant Melanoma ◽

Salvage Neck Dissection

Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon–ion radiotherapy with concurrent chemotherapy are not well described, and carbon–ion radiation protocols have not been fully developed. A 77 year old woman with crT0N1M0 mucosal melanoma of the head and neck achieved a complete response following initial treatment with carbon–ion radiotherapy and concurrent chemotherapy. She was treated with salvage neck dissection for as a cervical lymph node metastasis 16 months after initial treatment. She experienced neither Clavien-Dindo Grade 3 or 4 postoperative complications nor subsequent recurrence of disease at 3 months following salvage neck dissection. Surgical specimens may be useful for future precision oncology based on the molecular biology of recurrence melanoma with poor prognosis.

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