scholarly journals Comparison of Vascular Invasion With Lymph Node Metastasis as a Prognostic Factor in Stage I-III Colon Cancer: An Observational Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Jung Hoon Bae ◽  
Ji Hoon Kim ◽  
Bong-Hyeon Kye ◽  
Abdullah Al-Sawat ◽  
Chul Seung Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Metastasis ◽  
Vascular Invasion ◽  
Early Recurrence ◽  
Metastatic Colon Cancer ◽  
Group Iii ◽  
Node Metastasis ◽  
Group Ii

Purpose: This study aimed to evaluate the prognostic impact of vascular invasion (VI) in comparison with that of lymph node metastasis (LNM) in non-metastatic colon cancer.Methods: Patients who underwent curative surgery for stage I-III colon cancer were divided into four groups depending on the status of VI and LNM (Group I: VI-/LNM-; Group II: VI+/LNM-; Group III: VI-/LNM+; Group IV: VI+/LNM+). Group III was subdivided according to the nodal (N) stage (Group IIIA: VI-/N1; Group IIIB: VI-/N2). Oncological outcomes were compared between Groups II and III.Results: In total, 793 non-metastatic colon cancer patients were included. Group II [hazard ratio (HR) 2.34, 1.01–5.41] and Group III (HR 1.91, 1.26–2.89) were independently associated with poor disease-free survival (DFS). The 5-year DFS rates were comparable in Groups II (71.6%) and III (72.5%) (P = 0.637). When Group III was subdivided into Groups IIIA and IIIB, DFS deteriorated in the following order: Groups IIIA, II, and IIIB. The 5-year DFS rates were 79.7, 71.6, and 61.4% in Groups IIIA, II, and IIIB, respectively. Group II had a tendency toward early recurrence. The 1- and 2-year DFS rates were 76.3 and 71.6% in Group II and 88.3 and 79.8% in Group III, respectively (P = 0.067 and 0.247). All recurrences in Group II were distant metastases.Conclusion: VI is a prognostic factor as significant as LNM and may be a stronger prognostic factor than N1 stage in non-metastatic colon cancer. Furthermore, a potential association was observed between VI and recurrence patterns, such as early recurrence and distant metastasis.

scholarly journals Comparison of vascular invasion with lymph node metastasis as a prognostic factor in stage I-III colon cancer: an observational cohort study

2020 ◽  
Author(s):  
Jung Hoon Bae ◽  
Chul Seung Lee ◽  
Seung-Rim Han ◽  
Ji Hoon Kim ◽  
Bong-Hyeon Kye ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Metastasis ◽  
Vascular Invasion ◽  
Group Iv ◽  
Metastatic Colon Cancer ◽  
Group Iii ◽  
Node Metastasis ◽  
Group Ii

Abstract Background: The oncological impact of vascular invasion (VI), when compared with that of lymph node metastasis (LNM), has been underestimated in clinicopathological staging of colon cancer. This study aimed to evaluate the prognostic impact of VI in comparison with that of LNM in non-metastatic colon cancer.Methods: Patients who underwent surgery for stage I-III colon cancer were divided into four groups depending on the status of VI and LNM (Group I: VI-/LNM-; Group II: VI+/LNM-; Group III: VI-/LNM+; Group IV: VI+/LNM+). Group III was subdivided according to the node (N) stage (Group IIIA: VI-/N1; Group IIIB: VI-/N2). Disease-free survival (DFS) and overall survival were compared.Results: In total, 793 non-metastatic colon cancer patients were included. Group II (hazard ratio [HR] 2.34, 1.01-5.41), Group III (HR 1.91, 1.26-2.89), and Group IV (HR 2.34, 1.33-4.14) were independently associated with poor DFS. All recurrences in Group II occurred within 2 years and were distant metastases. The 1- and 2-year DFS rates were 76.3% and 71.6% in Group II and 88.3% and 79.8% in Group III, respectively (P = 0.067 and 0.247). In subgroup analysis, the 5-year DFS rates tended to be lower in Group II (71.6%) than in Group IIIA (79.7%) and higher than those in Group IIIB (61.4%).Conclusion: VI is a prognostic factor as significant as LNM and may be regarded as a stronger prognostic factor than N1 stage in non-metastatic colon cancer. Furthermore, a potential association was observed between VI and recurrence patterns, such as early recurrence and distant metastasis.

scholarly journals Papillary thyroid cancer with para-aortic lymph node metastasis discovered incidentally during work-up of metastatic colon cancer: a case report

2020 ◽  
Author(s):  
Yi Wang ◽  
Rongjing Zhou ◽  
Shangnao Xie
Keyword(s):  
Colon Cancer ◽  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Distant Metastases ◽  
Metastatic Colon Cancer ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Aortic Lymph Node

Abstract Background: Papillary thyroid cancer usually manifests an indolent behavior and infrequently causes rare distant metastases, with the exclusion of lung and bone metastases. Metastasis to the para-aortic lymph node from papillary thyroid cancer is extremely rare. Case presentation: The present study reports a case of a 71-year-old Chinese female with para-aortic lymph node metastasis from papillary thyroid cancer 12 months following total thyroidectomy, and synchronous intra-abdominal metastasis from colon cancer 18 months following right hemicolectomy. The patient was administered chemotherapy combined with targeted therapy post-operation. She developed lung metastasis and intra-abdominal relapse 6 months after the operation, and died of progressive disease 12 months after presentation. Conclusion: This study is the first to report a case of para-aortic lymph node metastasis from papillary thyroid cancer. Keywords: Papillary thyroid cancer, Lymph node, Metastasis

scholarly journals A Case of Early Sigmoid Colon Cancer with Micropapillary Carcinoma Component with Lymph Node Metastasis

2020 ◽  
Vol 73 (5) ◽  
pp. 202-208
Author(s):  
Hiroyuki Ozasa ◽  
Yasumi Araki ◽  
Toshihiro Noake ◽  
Keiko Matono ◽  
Masato Iwami ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Sigmoid Colon ◽  
Sigmoid Colon Cancer ◽  
Micropapillary Carcinoma ◽  
Node Metastasis

scholarly journals Axillary Lymph Node Metastasis of Colon Cancer—Case Report and Literature Review

2014 ◽  
Vol 03 (12) ◽  
pp. 669-673
Author(s):  
Helena Devesa ◽  
Luísa Pereira ◽  
Álvaro Gonçalves ◽  
Telma Brito ◽  
Teresa Almeida ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Literature Review ◽  
Axillary Lymph Node ◽  
Axillary Lymph Node Metastasis ◽  
Cancer Case ◽  
Axillary Lymph ◽  
Node Metastasis

scholarly journals Preoperative Predictors of Lymph Node Metastasis in Colon Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Yansong Xu ◽  
Yi Chen ◽  
Chenyan Long ◽  
Huage Zhong ◽  
Fangfang Liang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Logistic Regression ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Node Metastasis ◽  
Logistic Analysis ◽  
Primary Colon Cancer ◽  
Primary Colon

BackgroundLymph node metastasis (LNM) is a well-established prognostic factor for colon cancer. Preoperative LNM evaluation is relevant for planning colon cancer treatment. The aim of this study was to construct and evaluate a nomogram for predicting LNM in primary colon cancer according to pathological features.Patients and MethodsSix-hundred patients with clinicopathologically confirmed colon cancer (481 cases in the training set and 119 cases in the validation set) were enrolled in the Affiliated Cancer Hospital of Guangxi Medical University from January 2010 to December 2019. The expression of molecular markers (p53 and β-catenin) was determined by immunohistochemistry. Multivariate logistic regression was used to screen out independent risk factors, and a nomogram was established. The accuracy and discriminability of the nomogram were evaluated by consistency index and calibration curve.ResultsUnivariate logistic analysis revealed that LNM in colon cancer is significantly correlated (P <0.05) with tumor size, grading, stage, preoperative carcinoembryonic antigen (CEA) level, and peripheral nerve infiltration (PNI). Multivariate logistic regression analysis confirmed that CEA, grading, and PNI were independent prognostic factors of LNM (P <0.05). The nomogram for predicting LNM risk showed acceptable consistency and calibration capability in the training and validation sets.ConclusionsPreoperative CEA level, grading, and PNI were independent risk factor for LNM. Based on the present parameters, the constructed prediction model of LNM has potential application value.

scholarly journals Extent of D2 Surgery for Colon Cancer According to Tumor Location with Respect to Vascular Anatomy and Lymph Node Metastasis.

1996 ◽  
Vol 29 (3) ◽  
pp. 710-716
Author(s):  
Hirokazu Yada ◽  
Kiyoshi Sawai ◽  
Miyakatsu Ohara ◽  
Masataka Shimotsuma ◽  
Hiroki Taniguchi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Vascular Anatomy ◽  
Tumor Location ◽  
Node Metastasis ◽  
D2 Surgery
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