scholarly journals In Utero Exposure to Environmental Tobacco Smoke Increases Neuroinflammation in Offspring

2022 ◽  
Vol 3 ◽  
Author(s):  
Ana Carolina Cardoso dos Santos Durão ◽  
Wesley Nogueira Brandão ◽  
Vitor Bruno ◽  
Lídia Emmanuela W. Spelta ◽  
Stephanie de Oliveira Duro ◽  
...  
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Embryo Implantation ◽  
Sudden Infant Death ◽  
In Utero ◽  
Sudden Infant ◽  
Mixed Cell ◽  
Necrosis Factor Alpha ◽  
Lps Challenge ◽  
Pregnant Mice

The embryonic stage is the most vulnerable period for congenital abnormalities. Due to its prolonged developmental course, the central nervous system (CNS) is susceptible to numerous genetic, epigenetic, and environmental influences. During embryo implantation, the CNS is more vulnerable to external influences such as environmental tobacco smoke (ETS), increasing the risk for delayed fetal growth, sudden infant death syndrome, and immune system abnormalities. This study aimed to evaluate the effects of in utero exposure to ETS on neuroinflammation in the offspring of pregnant mice challenged or not with lipopolysaccharide (LPS). After the confirmation of mating by the presence of the vaginal plug until offspring birth, pregnant C57BL/6 mice were exposed to either 3R4F cigarettes smoke (Kentucky University) or compressed air, twice a day (1h each), for 21 days. Enhanced glial cell and mixed cell cultures were prepared from 3-day-old mouse pups. After cell maturation, both cells were stimulated with LPS or saline. To inhibit microglia activation, minocycline was added to the mixed cell culture media 24 h before LPS challenge. To verify the influence of in utero exposure to ETS on the development of neuroinflammatory events in adulthood, a different set of 8-week-old animals was submitted to the Autoimmune Experimental Encephalomyelitis (EAE) model. The results indicate that cells from LPS-challenged pups exposed to ETS in utero presented high levels of proinflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNFα) and decreased cell viability. Such a proinflammatory environment could modulate fetal programming by an increase in microglia and astrocytes miRNA155. This scenario may lead to the more severe EAE observed in pups exposed to ETS in utero.

Impact of Pre- and Postnatal Exposure to Environmental Tobacco Smoke (Ets) on Sudden Infant Death Syndrome (Sids)

Epidemiology ◽  
2009 ◽  
Vol 20 ◽  
pp. S51-S52
Author(s):  
Dimitri Hauri ◽  
Anke Huss ◽  
Evelyn Mohler ◽  
Patrizia Frei ◽  
Martin Röösli
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Postnatal Exposure

scholarly journals Effects of environmental tobacco smoke on the health of children in the Syrian Arab Republic

1999 ◽  
Vol 5 (4) ◽  
pp. 690-697
Author(s):  
W. Maziak ◽  
F. Mzayek ◽  
M. Al Musherref
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Rural Areas ◽  
Sudden Infant Death ◽  
Cross Sectional Study ◽  
Respiratory Morbidity ◽  
Sudden Infant ◽  
Cross Sectional ◽  
Syrian Arab Republic ◽  
Urban And Rural Areas

In the Syrian Arab Republic, studies on the effects of environmental tobacco smoke on children are lacking. We conducted a cross-sectional study on the effect of household environmental tobacco smoke on 1859 children under 12 years from both urban and rural areas. Parental and household smoking were associated with respiratory morbidity in the children. Parental smoking was associated with an increased likelihood of having sudden infant death syndrome in the family and was also associated with the presence of other smokers within households, which adds to children’s exposure. To our knowledge this is the first study in the Syrian Arab Republic to report a clear association between environmental tobacco smoke and childhood respiratory morbidity

Impact of Environmental Tobacco Smoke (ETS) on Sudden Infant Death Syndrome (SIDS) in European Children

Epidemiology ◽  
2007 ◽  
Vol 18 (Suppl) ◽  
pp. S58
Author(s):  
E Boldo ◽  
M Öberg ◽  
S Medina ◽  
N Valero ◽  
K Patja ◽  
...  
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant

Health Impact of Environmental Tobacco Smoke in the Horne

2004 ◽  
Vol 19 (3-4) ◽  
pp. 291-310
Author(s):  
Lesley Rushton
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Respiratory Illness ◽  
Sudden Infant Death ◽  
Health Impact ◽  
Major Constituent ◽  
Sudden Infant ◽  
Indoor Environments ◽  
Nasal Cancer ◽  
Increased Risk

Abstract Environmental tobacco smoke (ETS) can be a major constituent of air pollution in indoor environments, including the home. Regulation on smoking in the workplace and public places has made the home the dominant unregulated source of ETS, with important potential impacts on children. Between 40% and 60% of cbildren in the United Kingdom are exposed to ETS in the home. Many experimental and human and studies have investigated the adverse health effects of ETS. Substantial evidence shows that in adults ETS is associated with increased risk of chronic respiratory illness, including lung cancer, nasal cancer, and cardiovascular disease. In children, ETS increases the risk of sudden infant death syndrome, middle ear disease, lower respiratory tract illness, prevalence of wheeze and cough, and exacerbates asthma. Although banning smoking in the home would be the optimal reduction strategy, several barrier and ventilation methods can be effective. Nevertheless, such methods are not always practical or acceptable, particularly when social pressures contribute to a lack of support for ETS control in the home. Smoking cessation interventions have bad limited success. Research is needed to explore the barriers to adopting ETS risk-reducing behaviors.

scholarly journals Health Impact Assessment of Environmental Tobacco Smoke in European Children: Sudden Infant Death Syndrome and Asthma Episodes

2010 ◽  
Vol 125 (3) ◽  
pp. 478-487 ◽  
Author(s):  
Elena Boldo ◽  
Sylvia Medina ◽  
Mattias Öberg ◽  
Vladimíra Puklová ◽  
Odile Mekel ◽  
...  
Keyword(s):  
Impact Assessment ◽  
Sudden Infant Death Syndrome ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Infant Death ◽  
Health Impact Assessment ◽  
Sudden Infant Death ◽  
Health Impact ◽  
Sudden Infant

Prenatal and Postnatal Environmental Tobacco Smoke Exposure and Children’s Health

PEDIATRICS ◽  
2004 ◽  
Vol 113 (Supplement_3) ◽  
pp. 1007-1015 ◽  
Author(s):  
Joseph R. DiFranza ◽  
C. Andrew Aligne ◽  
Michael Weitzman
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Behavioral Problems ◽  
Fetal Development ◽  
Sudden Infant Death ◽  
Environmental Tobacco Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Sudden Infant ◽  
Postnatal Exposure ◽  
Tract Infections

Children’s exposure to tobacco constituents during fetal development and via environmental tobacco smoke (ETS) exposure is perhaps the most ubiquitous and hazardous of children’s environmental exposures. A large literature links both prenatal maternal smoking and children’s ETS exposure to decreased lung growth and increased rates of respiratory tract infections, otitis media, and childhood asthma, with the severity of these problems increasing with increased exposure. Sudden infant death syndrome, behavioral problems, neurocognitive decrements, and increased rates of adolescent smoking also are associated with such exposures. Studies of each of these problems suggest independent effects of both pre- and postnatal exposure for each, with the respiratory risk associated with parental smoking seeming to be greatest during fetal development and the first several years of life.

Risk of sudden infant death syndrome among infants with in utero exposure to cocaine

1988 ◽  
Vol 113 (5) ◽  
pp. 831-834 ◽  
Author(s):  
Howard Bauchner ◽  
Barry Zuckerman ◽  
Mary McClain ◽  
Deborah Frank ◽  
Lise E. Fried ◽  
...  
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sudden Infant Death ◽  
In Utero ◽  
Sudden Infant ◽  
In Utero Exposure
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