scholarly journals Correlation between Antibiotic Consumption and Resistance of Invasive Streptococcus pneumoniae

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 758
Author(s):  
Milan Čižman ◽  
Verica Mioč ◽  
Tom Bajec ◽  
Metka Paragi ◽  
Tamara Kastrin ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Broad Spectrum ◽  
Antibiotic Consumption ◽  
Penicillin Resistance ◽  
Total Consumption ◽  
New Finding ◽  
Very High ◽  
Long Term Studies

There is a lack of long-term studies that correlate different metrics of antibiotic consumption and resistance of invasive S. pneumoniae. The present study aims to investigate the correlation between national outpatients total antibiotic, penicillin and broad spectrum penicillins consumption expressed in daily doses per 1000 inhabitants per day (DID) with the ATC/DDDs, WHO version of 2019 (new version) and 2018 (old version), number of prescriptions per 1000 inhabitants per year (RxIDs) and number of packages per 1000 inhabitant per day (PIDs) with the resistance of invasive S. pneumoniae in Slovenia in the period from 2000 to 2018. The prevalence of penicillin resistance of invasive S. pneumoniae decreased by 47.13%, from 19.1% to 10.1%. Decline of resistance showed the highest correlation (R = 0.86) between RxIDs followed by PID (R = 0.85) and resistance of S. pneumoniae. Higher correlation between total use of antibiotics expressed in DID WHO version 2019 (R = 0.80) than for WHO version 2018 (R = 0.78) was found. Very high (R = 0.84) correlation between use of β-lactams expressed in PID, and RxIDs (R = 0.82) and reasonable (R = 0.59) correlation expressed in DIDs version 2019 was shown as well. The consumption of broad -spectrum penicillins (J01CA and J01CR02) expressed in PID (R = 0.72) and RxIDs (0.57) correlated significantly with the resistance of S. pneumoniae as well. A new finding of this study is that RxIDs correlated better with the resistance of S. pneumoniae than total consumption of antibiotics expressed in DID and significant correlations exist between use of broad-spectrum penicillins expressed in PID and RxIDs.

How Effective Are Antipsychotic Medications?

2015 ◽  
Vol 17 (3) ◽  
pp. 176-184 ◽  
Author(s):  
Colin A. Ross
Keyword(s):  
Psychosocial Interventions ◽  
Dropout Rates ◽  
Intervention Effectiveness ◽  
Antipsychotic Medications ◽  
Common Definition ◽  
Symptom Scores ◽  
Definition Of ◽  
Very High ◽  
Long Term Studies

A review of the effectiveness of antipsychotic medications was conducted with a focus on quetiapine, olanzapine, and clozapine. The different antipsychotics are equally effective if given in equivalent doses; therefore, what is true of one is true of all. In large, randomized, placebo-controlled studies, less than 15% of participants respond to antipsychotics, and in many trials less than 10%, if a response is defined as an 80% or greater reduction in symptom scores. Dropout rates are very high in long-term studies such as the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study (74%). A common definition of a “responder” in antipsychotic studies is a score reduction of 40% or greater, but in most studies, a participant can have a score reduction of 40% and still be psychotic enough to be reenrolled in the trial. Given the high percentage of nonresponders to antipsychotic medications, greater research and clinical emphasis should be placed on psychosocial interventions.

Implications of Long-Term Studies of Three Model Preschool Programs for Head Start

2008 ◽  
Author(s):  
Lawrence J. Schweinhart ◽  
Elena V. Malofeeva ◽  
Lawrence J. Schweinhart ◽  
Michelle M. Englund ◽  
Arthur J. Reynolds ◽  
...  
Keyword(s):  
Head Start ◽  
Preschool Programs ◽  
Long Term Studies

Primary varicose veins

Phlebologie ◽  
2010 ◽  
Vol 39 (03) ◽  
pp. 133-137
Author(s):  
H. Partsch
Keyword(s):  
Varicose Veins ◽  
Compression Therapy ◽  
Daily Practice ◽  
Clinical Severity ◽  
Compression Stockings ◽  
Primary Varicose Veins ◽  
The Cost ◽  
Convincing Data ◽  
Long Term Studies

SummaryBackground: Compression stockings are widely used in patients with varicose veins. Methods: Based on published literature three main points are discussed: 1. the rationale of compression therapy in primary varicose veins, 2. the prescription of compression stockings in daily practice, 3. studies required in the future. Results: The main objective of prescribing compression stockings for patients with varicose veins is to improve subjective leg complaints and to prevent swelling after sitting and standing. No convincing data are available concerning prevention of progression or of complications. In daily practice varicose veins are the most common indication to prescribe compression stockings. The compliance depends on the severity of the disorder and is rather poor in less severe stages. Long-term studies are needed to proof the cost-effectiveness of compression stockings concerning subjective symptoms and objective signs of varicose veins adjusted to their clinical severity. Conclusion: Compression stockings in primary varicose veins are able to improve leg complaints and to prevent swelling.

Diatoms and aquatic palynomorphs in the sediments of the Eurasian Arctic seas and their significance for paleooceanological investigations in the Arctic

2019 ◽  
pp. 246-251
Author(s):  
Yelena I. Polyakova ◽  
Yekaterina I. Novichkova ◽  
Tatiana S. Klyuvitkina ◽  
Elizaveta A. Agafonova ◽  
Irina M. Kryukova
Keyword(s):  
Bering Sea ◽  
Surface Sediments ◽  
Sea Water ◽  
The Arctic ◽  
Marginal Filter ◽  
Arctic Seas ◽  
Hydrological Parameters ◽  
The Arctic Ocean ◽  
Long Term Studies

Presented the results of long-term studies of diatoms and aquatic palynomorphs in surface sediments of the Arctic seas and the possibility of their use for the reconstructions of paleocirculation water masses, advection of Atlantic and Bering sea water into the Arctic ocean, changes in the river runoff to the seas, sedimentary processes in the marginal filter of the largest rivers, seasonal sea ice cover and other hydrological parameters.

Quintuplex PCR to Detect Antibiotic Resistance Genes in Streptococcus pneumoniae

2016 ◽  
Vol 1 (2) ◽  
pp. 22 ◽  
Author(s):  
Navindra Kumari Palanisamy ◽  
Parasakthi Navaratnam ◽  
Shamala Devi Sekaran
Keyword(s):  
Antibiotic Resistance ◽  
Streptococcus Pneumoniae ◽  
Resistance Genes ◽  
Bacterial Pathogen ◽  
Antibiotic Resistance Genes ◽  
Pcr Amplification ◽  
Penicillin Resistance ◽  
Penicillin Binding Proteins ◽  
Efflux Mechanism ◽  
Mic Value

Introduction: Streptococcus pneumoniae is an important bacterial pathogen, causing respiratory infection. Penicillin resistance in S. pneumoniae is associated with alterations in the penicillin binding proteins, while resistance to macrolides is conferred either by the modification of the ribosomal target site or efflux mechanism. This study aimed to characterize S. pneumoniae and its antibiotic resistance genes using 2 sets of multiplex PCRs. Methods: A quintuplex and triplex PCR was used to characterize the pbp1A, ermB, gyrA, ply, and the mefE genes. Fifty-eight penicillin sensitive strains (PSSP), 36 penicillin intermediate strains (PISP) and 26 penicillin resistance strains (PRSP) were used. Results: Alteration in pbp1A was only observed in PISP and PRSP strains, while PCR amplification of the ermB or mefE was observed only in strains with reduced susceptibility to erythromycin. The assay was found to be sensitive as simulated blood cultures showed the lowest level of detection to be 10cfu. Conclusions: As predicted, the assay was able to differentiate penicillin susceptible from the non-susceptible strains based on the detection of the pbp1A gene, which correlated with the MIC value of the strains.

Aspects of the Evolution of the Romanian Tourists’ Preferences Concerning the Domestic Tourist Destinations

2019 ◽  
Vol 10 (1) ◽  
pp. 21-28
Author(s):  
Aniela Bălăcescu ◽  
Radu Șerban Zaharia
Keyword(s):  
Logistic Model ◽  
Local Level ◽  
Medium Term ◽  
Tourist Destinations ◽  
Tourism Management ◽  
Production And Consumption ◽  
On Line ◽  
The One ◽  
Long Term Studies

Abstract Tourist services represent a category of services in which the inseparability of production and consumption, the inability to be storable, the immateriality, and last but not least non-durability, induces in tourism management a number of peculiarities and difficulties. Under these circumstances the development of medium-term strategies involves long-term studies regarding on the one hand the developments and characteristics of the demand, and on the other hand the tourist potential analysis at regional and local level. Although in the past 20 years there has been tremendous growth of on-line booking made by household users, the tour operators agencies as well as those with sales activity continue to offer the specific services for a large number of tourists, that number, in the case of domestic tourism, increased by 1.6 times in case of the tour operators and by 4.44 times in case of the agencies with sales activity. At the same time, there have been changes in the preferences of tourists regarding their holiday destinations in Romania. Started on these considerations, paper based on a logistic model, examines the evolution of the probabilities and scores corresponding to the way the Romanian tourists spend their holidays on the types of tourism agencies, actions and tourist areas in Romania.

Planning a system of permanent sample plots for integrated long-term studies of community-based forest management

1970 ◽  
Vol 16 (2) ◽  
pp. 3-11 ◽  
Author(s):  
H Meilby ◽  
L Puri ◽  
M Christensen ◽  
S Rayamajhi
Keyword(s):  
Forest Management ◽  
Key Words ◽  
Research Note ◽  
Managed Forests ◽  
Community Based ◽  
Permanent Sample Plots ◽  
Long Term Studies

To monitor the development of four community-managed forests, networks of permanent sample plots were established in 2005 at sites in Chitwan, Kaski and Mustang Districts, Nepal. This research note documents the procedures used when preparing for establishment of the plot networks, evaluates the applied stratification of the forest on the basis of data gathered in pilot surveys conducted in the early 2005, and provides a discussion on the implications of the choices made. Key words: Community-managed forests; permanent sample plots; stratification; allocation; estimates Banko Janakari Vol.16(2) 2006 pp.3-11

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