scholarly journals Metabolomics Studies to Assess Biological Functions of Vitamin E Nicotinate

Antioxidants ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 127 ◽  
Author(s):  
Lucia Marcocci ◽  
Yuichiro J. Suzuki
Keyword(s):  
Vitamin E ◽  
Biological Function ◽  
Cultured Cells ◽  
Hydroxyl Group ◽  
Active Vitamin ◽  
Vitamin B3 ◽  
Fatty Acid Amides ◽  
Vitamin E Acetate ◽  
Metabolite Profiles ◽  
Mitogen Activated Protein

Vitamin E nicotinate (tocopherol nicotinate, tocopheryl nicotinate; TN) is an ester of two vitamins, tocopherol (vitamin E) and niacin (vitamin B3), in which niacin is linked to the hydroxyl group of active vitamin E. This vitamin E ester can be chemically synthesized and is used for supplementation. However, whether TN is formed in the biological system was unclear. Our laboratory previously detected TN in rat heart tissues, and its level was 30-fold lower in a failing heart (Wang et al., PLoS ONE 2017, 12, e0176887). The rat diet used in these experiments contained vitamin E acetate (tocopherol acetate; TA) and niacin separately, but not in the form of TN. Since only TN, but not other forms of vitamin E, was decreased in heart failure, the TN structure may elicit biologic functions independent of serving as a source of active vitamin E antioxidant. To test this hypothesis, the present study performed metabolomics to compare effects of TN on cultured cells to those of TA plus niacin added separately (TA + N). Human vascular smooth muscle cells were treated with TN or with TA + N (100 μM) for 10 min. Metabolite profiles showed that TN and TA + N influenced the cells differentially. TN effectively upregulated various primary fatty acid amides including arachidonoylethanoamine (anandamide/virodhamine) and palmitamide. TN also activated mitogen-activated protein kinases. These results suggest a new biological function of TN to elicit cell signaling.

scholarly journals Metabolism of vitamin E acetate by reconstituted human gingival and buccal epithelium

2007 ◽  
Vol 57 ◽  
pp. 135-139 ◽  
Author(s):  
A.E. Scott ◽  
J. Alcock ◽  
M.J. Carlile ◽  
H.R. Griffiths
Keyword(s):  
Vitamin E ◽  
Buccal Epithelium ◽  
Vitamin E Acetate

scholarly journals Topical Vitamin E Acetate for the Treatment of Cheilitis: A Multicentre Experience

2003 ◽  
Vol 1 (3) ◽  
pp. 125-128 ◽  
Author(s):  
N. Cassano ◽  
M. De Benedittis ◽  
M. Petruzzi ◽  
M. Carbonara ◽  
C. Agnusdei ◽  
...  
Keyword(s):  
Vitamin E ◽  
Adverse Reactions ◽  
Contact Allergy ◽  
Response To Treatment ◽  
Vitamin E Acetate ◽  
Frequent Form ◽  
Oral Isotretinoin ◽  
Safe Approach ◽  
Symptoms And Signs ◽  
Overall Effectiveness

Treatment of cheilitis is usually difficult and often disappointing. We evaluated the effects of a topical preparation containing vitamin E acetate (VEA® lipogel) in 254 patients (mean age, 29.5) with cheilitis of various nature and etiology, involving the vermilion region and/or the perioral skin. The most frequent form of cheilitis was that induced by oral isotretinoin; other forms were irritant contact dermatitis, atopic cheilitis, and contact allergy. Patients were instructed to apply VEA® lipogel daily; the number of daily applications was modulated on the basis of the severity of symptoms (two or three times a day in the majority of cases). After 4 weeks of treatment, clinical examination showed that the severity of symptoms and signs significantly improved (P<0.001). The response to treatment was reported as particularly rapid by 32% of patients. Patient's assessment of overall effectiveness and acceptability was positive in the majority of cases. Treatment was well tolerated; local adverse reactions were observed in 2.75% of patients and were mostly transient and mild. Our experience suggests that VEA® lipogel is an effective and safe approach to cheilitis. The safety of this preparation is also due to the presence of only a few excipients and the absence of fragrances, preservatives and colouring agents.

Gas-Liquid Chromatographic Determination of Vitamin D2 in Multiple Vitamin Tablets Containing Minerals and Vitamin E Acetate

1974 ◽  
Vol 57 (5) ◽  
pp. 1089-1091
Author(s):  
David O Edlund ◽  
Florido A Filippini ◽  
James K Datson
Keyword(s):  
Vitamin E ◽  
Chromatographic Determination ◽  
Vitamin D2 ◽  
Vitamin E Acetate ◽  
Chromatographic Procedure ◽  
Ether Solution ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic ◽  
Column Chromatographic

Abstract A gas-liquid chromatographic procedure used to determine vitamin D2 in multiple vitamin tablets has been modified to make it applicable for analysis of multiple vitamin tablets containing minerals and vitamin E acetate. The procedure modifications involve pre-extraction with ether, solution in an alcoholic sulfuric acid-pyridine mixture, and column chromatographic separation on phosphate-treated alumina. The modified procedure has been statistically evaluated. A 2.2% coefficient of variation and 100.3% average recovery were obtained for the samples evaluated.

scholarly journals Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI

2020 ◽  
Vol 382 (8) ◽  
pp. 697-705 ◽  
Author(s):  
Benjamin C. Blount ◽  
Mateusz P. Karwowski ◽  
Peter G. Shields ◽  
Maria Morel-Espinosa ◽  
Liza Valentin-Blasini ◽  
...  
Keyword(s):  
Vitamin E ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Vitamin E Acetate

Culprit or correlate? An application of the Bradford Hill criteria to Vitamin E acetate

2020 ◽  
Vol 94 (6) ◽  
pp. 2249-2254 ◽  
Author(s):  
Ryan Feldman ◽  
Jonathan Meiman ◽  
Matthew Stanton ◽  
David D. Gummin
Keyword(s):  
Vitamin E ◽  
Vitamin E Acetate ◽  
Bradford Hill ◽  
Bradford Hill Criteria ◽  
Hill Criteria
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