scholarly journals Advances in Biomaterials for Breast Reconstruction

2021 ◽  
Vol 11 (16) ◽  
pp. 7493
Author(s):  
Jun-Ho Park ◽  
Ji-Ung Park ◽  
Hak Chang
Keyword(s):  
Breast Reconstruction ◽  
Breast Tissue ◽  
Breast Implant ◽  
Three Dimensional ◽  
Breast Implants ◽  
3D Bioprinting ◽  
Breast Enlargement ◽  
Liquid Type ◽  
The 1960S ◽  
Solid Implants

Breast cancer is one of the most commonly diagnosed malignancies in women. Along with increasing demands for breast reconstruction, the attention given to the psychological and aesthetic benefits of breast reconstruction has also increased. As breast reconstruction and augmentation demands increase, biomaterials for breast reconstruction are being developed, and the related industry is growing quickly worldwide. Among the various biomaterials used for breast enlargement, breast implants have undergone a remarkable evolution since the 1960s. Despite unsatisfactory results and unexpected complications, research dedicated to achieving an ideal breast implant has progressed. In accordance with attention to tissue engineering, a three-dimensional (3D) bioprinting technique for breast tissue regeneration has emerged to overcome the current limitations of breast biomaterials. Along with solid implants, injectable liquid-type fillers are also part of ongoing studies.

scholarly journals Thoracic migration of silicone gel after breast implant rupture: a case report and literature review

2021 ◽  
Author(s):  
Benedetta Fanelli ◽  
Marco Marcasciano ◽  
Stefano Lovero ◽  
Luca Codolini ◽  
Donato Casella ◽  
...  
Keyword(s):  
Breast Reconstruction ◽  
Biological Membrane ◽  
Breast Implant ◽  
Granulomatous Inflammation ◽  
Breast Implants ◽  
Silicone Implants ◽  
Axillary Lymph ◽  
Implant Rupture ◽  
Silicone Gel ◽  
Breast Implant Rupture

AbstractNowadays silicone is a widespread material for medical devices. In particular, it is commonly used for implants manufacturing, for that patients undergoing breast augmentation or breast reconstruction after mastectomy. However, the use of silicone implants is not free from risks. Ruptures of silicone breast implants are uncommon, in general post-traumatic or iatrogenic, and usually related to implant’s wall weakness of unknown origin but probably due to biochemical reactions that cause wall rupture. As a consequence of a rupture, silicone gel from damaged implants may have a continuity migration to the chest wall, axillae, and upper extremities, resulting in granulomatous inflammation or siliconoma, or a lymphatic migration to axillary lymph nodes. In this regard, silicone thoracic migration is extremely rare, and nowadays a leakage is unlikely to happen with more modern cohesive silicone gel implants. Nevertheless, procedures such as thoracic surgery and thoracotomies may be responsible for accidental breast implant rupture, capsular discontinuity, and eventually intrathoracic silicone migration, especially when dealing with older generations of breast implants. We report a rare case of a 75-year-old woman presenting with pleural silicone effusion, 18 years after a right breast reconstruction for breast cancer, followed by right upper lobe resection for a lung carcinoma. A combination of muscular flap and DTI pre-pectoral breast reconstruction with biological membrane (ADM) has been used for treatment. Literature was reviewed for cases of breast implants free silicone localization in the chest cavity, focusing on previous surgeries, anamnestic relevances, and surgical management.Level of Evidence: Level V, risk/prognostic study.

scholarly journals BellaGel breast implant: 6-Year results of a prospective cohort study

2020 ◽  
Vol 47 (3) ◽  
pp. 235-241
Author(s):  
Joon Seok Oh ◽  
Jae Hoon Jeong ◽  
Yujin Myung ◽  
Jeongseok Oh ◽  
Shin Hyeok Kang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Study ◽  
Breast Reconstruction ◽  
Breast Implant ◽  
Capsular Contracture ◽  
Breast Implants ◽  
Asian Women ◽  
Safety And Efficacy ◽  
Implant Rupture ◽  
Cohesive Silicone Gel

Background This is the first clinical study conducted among Asian women using breast implants manufactured by an Asian company. Four-year data regarding the safety and efficacy of BellaGel breast implants have already been published, and we now report 6-year data.Methods This study was designed to take place over 10 years. It included 103 patients who underwent breast reconstruction or augmentation using BellaGel breast implants. The rates of implant rupture and capsular contracture were measured and analyzed to evaluate the effectiveness of the breast implant.Results At patients’ 6-year postoperative visits, the implant rupture and capsular contracture rates were 1.15% and 2.30%, respectively. The implant rupture rate was 3.77% among reconstruction cases and 0% among augmentation cases. The capsular contracture rate was 5.66% among reconstruction cases and 0.83% among augmentation cases.Conclusions The 6-year data from this planned 10-year study suggest that the BellaGel cohesive silicone gel-filled breast implant is an effective and safe medical device that can be used in breast reconstruction and augmentation.

scholarly journals Unusual Case of Anaplastic Large Cell Lymphoma Presenting as a Breast Mass in a Patient with no History of Breast Implants

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Yana Ivashkevich ◽  
Yaroslav Chernov ◽  
Denis Chinenov ◽  
Evgeniy Shpot ◽  
Alexander A. Bessonov ◽  
...  
Keyword(s):  
Breast Tissue ◽  
Breast Implant ◽  
Malignant Neoplasm ◽  
Breast Implants ◽  
Large Cell ◽  
Breast Mass ◽  
Lower Percentage ◽  
Primary Lymphoma ◽  
Malignant Neoplasms ◽  
History Of

Adenocarcinoma is the most common malignant neoplasm involving breast tissue. In contrast to carcinomas, the other types of malignant neoplasms involving the breast are relatively uncommon. One of the examples of this rare entity is lymphoma. Traditionally, non-Hodgkin lymphomas (NHL) involving the breast are divided into primary lymphoma of the breast and systemic lymphoma, although the distinction could be challenging. Most of NHL involving breast tissue have B cell origin; T cell NHL represents less than 20% of all lymphoma cases. Anaplastic large cell lymphomas (ALCL) involving the breast accounts for even lower percentage of cases. Similar to ALCL involving other sites, there are several main types of ALCL identified: primary cutaneous ALCL and systemic ALCL, which is subdivided into ALK positive and ALK negative subtypes. Relatively recently, an additional distinct subtype of ALK-negative ALCL was described, which is associated with textured breast implants and needs to be considered as a differential diagnosis if patient has a history of breast implants. Here, we report a case of ALCL presented as a breast mass without history of breast implant and discuss similar cases published in the literature.

scholarly journals Case Report: Early Breast Cancer Recurrence Mimicking BIA-ALCL in a Patient With Multiple Breast Procedures

2021 ◽  
Vol 8 ◽  
Author(s):  
Marco Materazzo ◽  
Gianluca Vanni ◽  
Marco Pellicciaro ◽  
Lucia Anemona ◽  
Francesca Servadei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Reconstruction ◽  
Locoregional Recurrence ◽  
Breast Implant ◽  
Skin Flap ◽  
False Negative ◽  
Cancer Recurrence ◽  
Breast Implants ◽  
Large Cell ◽  
Immediate Breast Reconstruction

Breast reconstruction plays a fundamental role in the therapeutic process of breast cancer treatment and breast implants represents the leading breast reconstruction strategy. Breast Implant Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL), locoregional recurrence in the skin flap, and skin flap necrosis are well-known complications following mastectomy and immediate breast reconstruction (IBR). We report a case of locoregional cancer recurrence in the mastectomy flap mimicking BIA-ALCL, in a patient who underwent 6 breast procedures in four facilities across 15 years including immediate breast reconstruction with macrotextured breast implants. Despite the rate and onset of the disease, clinicians should be aware of BIA-ALCL. Due to the risk of false negative results of fine needle aspiration, clinical suspicion of BIA-ALCL should drive clinicians' choices, aside from cytological results. In the present case, surgical capsulectomy of the abnormal periprosthesic tissue revealed locoregional recurrence.

Risk of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3,546 women prospectively followed after receiving textured breast implants.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 1565-1565 ◽  
Author(s):  
Paola Ghione ◽  
Peter G. Cordeiro ◽  
Ai Ni ◽  
Qunying Hu ◽  
Nivetha Ganesan ◽  
...  
Keyword(s):  
Breast Reconstruction ◽  
Cell Lymphoma ◽  
Breast Implant ◽  
Breast Implants ◽  
Large Cell ◽  
Long Term Follow Up ◽  
Large Cell Lymphoma ◽  
Prospective Database

1565 Background: Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare subtype of T-cell lymphoma, developing in in the fluid or capsule surrounding breast implants, primarily or exclusively in those with textured surfaces. Several prior series have estimated the risk of BIA- ALCL at 1/6920 - 1/3800 women in retrospectively defined cohorts (from diagnosed cases within national or pathology databases), approximating the population at risk from sales records or other estimates (Sirinvasa 2017; Loch-Wilkinson 2017; de Boer 2018). Methods: A prospective cohort study was conducted in the population that underwent breast reconstruction by a single surgeon at Memorial Sloan Kettering Cancer Center (MSKCC) from April 1993 to December 2017. Patients had long-term follow-up, and events related to implants were prospectively recorded. We identified all cases of BIA-ALCL by cross-checking data from internal clinical records, pathology records, and outside reports. Incidence rate per person-years and cumulative incidence when accounting for competing risk were calculated. 134 women who received smooth-surface implants were excluded from the analysis, since these implants have not been associated with BIA-ALCL. Results: From 1993 to 2017, 3546 patients underwent 6023 breast reconstructions using textured surface implants. All reconstructions were performed by a single surgeon (PGC) on patients enrolled in this study. To identify BIA-ALCL occurrence, clinical and pathological data were assessed from a prospective database. Median follow-up was 7 years (range, 3 days - 24.7 years). Eight women developed ALCL after a median exposure of 11.2 years (range, 8.3-15.8 years). Overall risk of BIA-ALCL in this cohort was 0.294 cases per 1000 person-years (1/443 women). Conclusions: This study, evaluating the risk of women with textured breast implants from a prospective database with long-term follow-up, demonstrated that the incidence rate of BIA-ALCL may be higher than previously reported. These results can help inform implant choice for women undergoing breast reconstruction.

scholarly journals Self-Reported Health Complaints In Women Undergoing Explantation of Breast Implants

2020 ◽  
Author(s):  
Renée M L Miseré ◽  
René R W J van der Hulst
Keyword(s):  
Breast Reconstruction ◽  
Medical Center ◽  
Breast Implant ◽  
Tissue Expander ◽  
Retrospective Chart Review ◽  
Breast Implants ◽  
Good Alternative ◽  
Health Complaints ◽  
Implant Rupture ◽  
Patient Reported

Abstract Background Concerns about the safety of silicone breast implants have existed for years, but a causal relationship between systemic complaints and SBI has not been proven. Nevertheless, women are worried and even request explantation. Objectives This study aimed to review the explantation procedures performed, focusing on patient-reported symptoms preoperatively, the effect of explantation, and the effect of breast reconstruction on these symptoms. Methods A retrospective chart review was performed for patients who had undergone explantation between 2010 and 2020 at Maastricht University Medical Center. Patients excluded were those who had undergone tissue expander (TE) removal, TE to implant exchange, and direct implant exchange. Results More than half of the patients undergoing explantation reported complaints, mostly pain. Some 15% reported suggested implant-related systemic complaints. Breast implant illness (BII) was found to be the fifth most common indication for explantation (11.2%). A history of either allergies or implant rupture resulted in higher odds ratios of having BII (OR=2.1 and 2.1, respectively). Subjective improvement of BII after explantation was reported in about 60%. Conclusions A relatively low prevalence of suggested BII exists among women undergoing explantation; one in nine procedures was performed for this reason. Allergy and implant rupture may increase the likelihood of having BII. About 60% of BII patients experienced an improvement in their complaints after implant removal. Autologous breast reconstruction appears a good alternative. Prospective studies into health complaints and quality of life should be performed to confirm the effectiveness of explantation as a therapy for BII.

scholarly journals Patient-Awareness Survey: Do Breast Implants Affect the Acquisition and Accuracy of Screening Mammography?

2019 ◽  
Vol 1 (4) ◽  
pp. 297-302
Author(s):  
Kristin A Robinson ◽  
Richard J Gray ◽  
Aneri Tanna ◽  
Heidi E Kosiorek ◽  
Richard J Butterfield ◽  
...  
Keyword(s):  
Breast Augmentation ◽  
Breast Imaging ◽  
Breast Tissue ◽  
Breast Surgery ◽  
Breast Implant ◽  
Breast Implants ◽  
The United States ◽  
Screening Mammography ◽  
Patient Awareness ◽  
Institutional Review

Abstract Objective Breast implant augmentation is the most common cosmetic surgical procedure performed in the United States. The purpose of this study was to determine if patients with breast augmentation surgery are aware of the effect of breast implants on the mammographic detection of cancer. Methods An institutional review board exempt patient awareness survey was distributed at a single breast imaging facility to women undergoing screening mammography. Comparative statistical analyses were performed between patients with and without breast implants. Results The respondents were divided into three groups: no prior breast surgery (74%; 524/711), breast surgery with implants (21%; 152/711), and breast surgery without implants (5%; 35/711). Patients with breast implants were more aware that implants decrease the amount of breast tissue seen on a mammogram (75%; 105/141) and that implants result in the need for more mammogram views (70%; 103/147), as compared with patients with no surgery (46%; 221/484 and 31%; 147/478, respectively) (P < 0.001). More women with breast implants reported learning from breast imaging staff rather than from their surgeon that implants decrease the amount of breast tissue seen on a mammogram (46%; 49/106 vs. 38%; 40/106). Of 137 respondents, 35% (n = 48) reported that the effect of implants on their mammogram was discussed preoperatively. Of those who did not recall a preoperative discussion, 42% (16/38) indicated this knowledge would have factored into their decision to get breast implants. Conclusion This study highlights an opportunity for providers to engage in more education and shared decision-making with patients considering breast augmentation surgery to ensure preoperative counseling includes discussion of the effect of implants on mammography.

scholarly journals Giant phyllodes tumor occupying the whole breast in a young female: feasibility of mastectomy and immediate reconstruction

2020 ◽  
Vol 2020 (4) ◽  
Author(s):  
Aikaterini K Kolia ◽  
Vasileios Kalles ◽  
Constantinos G Zografos ◽  
Alexandros Chamzin ◽  
Nikolaos V Michalopoulos
Keyword(s):  
Breast Reconstruction ◽  
Breast Tissue ◽  
Tissue Expander ◽  
Breast Implants ◽  
Phyllodes Tumor ◽  
Young Female ◽  
Immediate Breast Reconstruction ◽  
Immediate Reconstruction ◽  
Phyllodes Tumors ◽  
Appropriate Therapy

Abstract Giant phyllodes tumors are rare fibroepithelial breast neoplasms typically >10 cm by definition. The best investigation for preoperative diagnosis is core biopsy, although it is often difficult for the pathologist to distinguish fibroadenomas from phyllodes tumors and determine the level of malignant potential. The wide excision is the appropriate therapy for phyllodes tumors taking into consideration that mastectomy may be required for huge phyllodes tumors. In the modern era of breast tissue expanders and breast implants, immediate breast reconstruction is feasible. We present a case report of a patient with a giant phyllodes tumor of 24 cm diameter who underwent mastectomy and immediate breast reconstruction with breast tissue expander.

scholarly journals Use of New Technologies in Implant-Based Breast Reconstruction

2019 ◽  
Vol 33 (04) ◽  
pp. 258-263
Author(s):  
Glyn E. Jones ◽  
Victor A. King ◽  
Aran Yoo ◽  
Amjed Abu-Ghname ◽  
Charalambos K. Rammos
Keyword(s):  
Breast Reconstruction ◽  
New Technologies ◽  
Breast Implant ◽  
Tissue Expander ◽  
Improved Outcomes ◽  
Reconstructive Process ◽  
Perfusion Assessment ◽  
The 1960S ◽  
Instrumental Methods ◽  
Mastectomy Flap

AbstractOutcomes after mastectomy and prosthetic-based breast reconstruction have improved immensely since the development of the first tissue expander and breast implant in the 1960s. One major factor contributing to our improved outcomes over the past two decades is the increasing availability and improvement of perfusion assessment technology. Instrumental methods now exist which allow surgeons to assess tissue viability intraoperatively, and provide actionable, objective data that augments clinical assessment. In this article, the authors detail two commercially available, state-of-the-art technologies that surgeons may use to assist in mastectomy flap assessment and facilitate the reconstructive process.

scholarly journals Can we Measure a Woman’s Cancer Risk When Breast Implants are Present? – YES!!!

2020 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Breast Imaging ◽  
Breast Tissue ◽  
Regional Blood Flow ◽  
Breast Implant ◽  
Treatment Options ◽  
Breast Implants ◽  
Molecular Breast Imaging ◽  
The Face ◽  
Unique Method ◽  
Potential Methods

Background: Breast implants are now recognized to be associated with a variety of potential problems, including inflammatory changes – both locally and systemically – precancerous and cancerous changes. Monitoring these changes are particularly problematic in the face of breast implants. Molecular breast imaging (MBI) using FMTVDM* provides a unique method for measuring changes in breast tissue in these individuals. This study examines that potential. Methods: Eighteen breast implants were evaluated in women who had undergone implantation for a variety of reasons. These women underwent measurement of regional blood flow (RBF) and metabolism differences to determine the extent of inflammation, precancerous and cancerous changes. Results: Measured changes in RBF and metabolism were not influenced by breast implants. Among the 18 breast implant studies; there were 4 instances of inflammation (22%), 5 (28%) instances of precancerous changes and 1 (5%) instance of breast cancer. Conclusions: MBI using FMTVDM provides a non-invasive ability to measure changes in breast tissue in women who have undergone breast implantation. The measured monitoring of these changes allows clinicians a tool to make clinical decisions regarding either the need to remove the breast implant or provide alternative treatment options.

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