scholarly journals Can we Measure a Woman’s Cancer Risk When Breast Implants are Present? – YES!!!

2020 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Breast Imaging ◽  
Breast Tissue ◽  
Regional Blood Flow ◽  
Breast Implant ◽  
Treatment Options ◽  
Breast Implants ◽  
Molecular Breast Imaging ◽  
The Face ◽  
Unique Method ◽  
Potential Methods

Background: Breast implants are now recognized to be associated with a variety of potential problems, including inflammatory changes – both locally and systemically – precancerous and cancerous changes. Monitoring these changes are particularly problematic in the face of breast implants. Molecular breast imaging (MBI) using FMTVDM* provides a unique method for measuring changes in breast tissue in these individuals. This study examines that potential. Methods: Eighteen breast implants were evaluated in women who had undergone implantation for a variety of reasons. These women underwent measurement of regional blood flow (RBF) and metabolism differences to determine the extent of inflammation, precancerous and cancerous changes. Results: Measured changes in RBF and metabolism were not influenced by breast implants. Among the 18 breast implant studies; there were 4 instances of inflammation (22%), 5 (28%) instances of precancerous changes and 1 (5%) instance of breast cancer. Conclusions: MBI using FMTVDM provides a non-invasive ability to measure changes in breast tissue in women who have undergone breast implantation. The measured monitoring of these changes allows clinicians a tool to make clinical decisions regarding either the need to remove the breast implant or provide alternative treatment options.

scholarly journals Reno Cardiologist Confirms FMTVDM – Opening New Opportunities for Nuclear Cardiologists

2019 ◽  
Vol 1 (1) ◽  
pp. 01-04
Author(s):  
Richard Fleming
Keyword(s):  
Breast Cancer ◽  
Blood Flow ◽  
Myocardial Perfusion Imaging ◽  
Myocardial Perfusion ◽  
Perfusion Imaging ◽  
Private Practice ◽  
Breast Imaging ◽  
Breast Tissue ◽  
Regional Blood Flow ◽  
Molecular Breast Imaging

Background: A quantitative myocardial perfusion imaging (MPI) and oncologic - including molecular breast imaging (MBI) - utility patent (FMTVDM*) previously validated at experienced MPI and MBI centers was independently tested for clinical application at a private practice Reno, Nevada cardiologists office. Methods: Using FMTVDM, a private practice cardiologist independently investigated forty-four regions of interest (ROI) in 12-women with varying transitional levels of breast changes – including breast cancer. Results: Using FMTVDM, a nuclear cardiologist without prior experience in MBI was able to easily measure changes in women’s breast tissue differentiating inflammatory and cancerous breast tissue from normal using the same camera used for MPI. These measured changes provided diagnostically useful information on cellular metabolism and regional blood flow changes (RBF) – the same properties which differentiate ischemic coronary artery disease (CAD) on myocardial perfusion imaging (MPI). Conclusions: Quantitative MBI using FMTVDM allows differentiation of tissue types through measurement of enhanced regional blood flow and metabolic differences. Nuclear cardiologists have previously reported cases of breast cancer while conducting MPI studies. This investigation demonstrated that nuclear cardiologists can independently conduct MBI in addition to MPI studies using the nuclear cameras they currently use for MPI.

scholarly journals Patient-Awareness Survey: Do Breast Implants Affect the Acquisition and Accuracy of Screening Mammography?

2019 ◽  
Vol 1 (4) ◽  
pp. 297-302
Author(s):  
Kristin A Robinson ◽  
Richard J Gray ◽  
Aneri Tanna ◽  
Heidi E Kosiorek ◽  
Richard J Butterfield ◽  
...  
Keyword(s):  
Breast Augmentation ◽  
Breast Imaging ◽  
Breast Tissue ◽  
Breast Surgery ◽  
Breast Implant ◽  
Breast Implants ◽  
The United States ◽  
Screening Mammography ◽  
Patient Awareness ◽  
Institutional Review

Abstract Objective Breast implant augmentation is the most common cosmetic surgical procedure performed in the United States. The purpose of this study was to determine if patients with breast augmentation surgery are aware of the effect of breast implants on the mammographic detection of cancer. Methods An institutional review board exempt patient awareness survey was distributed at a single breast imaging facility to women undergoing screening mammography. Comparative statistical analyses were performed between patients with and without breast implants. Results The respondents were divided into three groups: no prior breast surgery (74%; 524/711), breast surgery with implants (21%; 152/711), and breast surgery without implants (5%; 35/711). Patients with breast implants were more aware that implants decrease the amount of breast tissue seen on a mammogram (75%; 105/141) and that implants result in the need for more mammogram views (70%; 103/147), as compared with patients with no surgery (46%; 221/484 and 31%; 147/478, respectively) (P < 0.001). More women with breast implants reported learning from breast imaging staff rather than from their surgeon that implants decrease the amount of breast tissue seen on a mammogram (46%; 49/106 vs. 38%; 40/106). Of 137 respondents, 35% (n = 48) reported that the effect of implants on their mammogram was discussed preoperatively. Of those who did not recall a preoperative discussion, 42% (16/38) indicated this knowledge would have factored into their decision to get breast implants. Conclusion This study highlights an opportunity for providers to engage in more education and shared decision-making with patients considering breast augmentation surgery to ensure preoperative counseling includes discussion of the effect of implants on mammography.

Breast Implant Related Anaplastic Large Cell Lymphoma ALK- (ALCL ALK-) – Case Report

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 5086-5086 ◽  
Author(s):  
Alejandro Arbelaez ◽  
Laurence Catley ◽  
Louis Pool
Keyword(s):  
Conflicts Of Interest ◽  
Case Reports ◽  
Breast Implant ◽  
Treatment Options ◽  
Fluid Collection ◽  
Case Series ◽  
Breast Implants ◽  
Large Cell ◽  
Lymphoid Cells ◽  
Malignant Cells

Abstract Case presentation A 29 underwent bilateral cosmetic breast augmentation 10 years previously (McGhan Textured Round 400 mL implants). Six months before, she developed slowly progressive right breast pain and inflammatory signs associated with fluid collection around the right breast that was drained. A yellow cloudy fluid was examined and showed atypical large lymphoid cells. The cell block prepared in another institution showed numerous lymphoid cells including large atypical cells with lobated nuclei. PET CT scan was negative, same as bone marrow aspirate and trephine for lymphoma infiltration. Following bilateral removal of the breast implants, further histopathology studies showed no infiltration by lymphoma of the breast capsules or scar tissue. However, right breast peri prosthetic fluid microscopy showed a population of single malignant cells with scanty cytoplasm, numerous mitosis, and nuclei showing single and multiple nucleoli. Some cells showing horseshoe nuclei. The malignant cells were positive for CD30 and LCA and negative for CD20, CD68, AE1-3, and ALK 1. FISH for ALK was not possible (Fig 1) Discussion Primary breast lymphomas are very rare conditions; they represent less than 1% of all NHL and less than 0.7% of all breast malignancies. There have been some cases reported in the medical literature of ALCL ALK- associated with breast implants. All the cases have been described in patients with textured implants, such as in this case and the reason is unknown. There are two main types of ALCL of the breast based on published case reports: a mass and an effusion. Primary breast effusion associated ALCL portends a good prognosis despite the fact that they are ALK-. The development of ALCL proximal to breast implants suggests that they are the result of an immune reaction to the silicone. Whether they represent true malignancy or a localised reactive phenomenon is not entirely clear yet. In previous case series, the condition has been described as indolent. However, given the low incidence of this condition and the limited literature available; it is difficult to know what the best treatment approach is. Following confirmation of the diagnosis, treatment options were discussed with the patient and the preferred option was active treatment with local radiation after removal of breast implants. Disclosures: No relevant conflicts of interest to declare.

Supplemental Breast Cancer Screening With Molecular Breast Imaging for Women With Dense Breast Tissue

2016 ◽  
Vol 207 (2) ◽  
pp. 450-457 ◽  
Author(s):  
Robin B. Shermis ◽  
Keith D. Wilson ◽  
Malcolm T. Doyle ◽  
Tamara S. Martin ◽  
Dawn Merryman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Breast Imaging ◽  
Breast Tissue ◽  
Dense Breast ◽  
Molecular Breast Imaging ◽  
Dense Breast Tissue

Role of mammography to assess complications of silicone gel breast implants

1995 ◽  
Vol 3 (3) ◽  
pp. 1-9 ◽  
Author(s):  
Walter Peters ◽  
Dennis Smith ◽  
Harvey Grosman ◽  
Victor Fornasier
Keyword(s):  
Breast Imaging ◽  
Breast Implant ◽  
Breast Implants ◽  
Cystic Mass ◽  
Implant Removal ◽  
The Other ◽  
Serous Effusion ◽  
Implant Rupture ◽  
Sensitivity Rate

Mammography is not accurate to predict implant rupture in most patients. Its sensitivity rate is only 11 to 16%. However, two mammographic findings appear to suggest implant rupture: the appearance of large areas of implant herniation, and the appearance of silicone globules lying outside the margins of the implant. Mammography is also helpful to predict capsular calcification and to assess certain complications of retained breast implant capsules. Two patients presented with retained capsules which had not resolved, two and five years after implant removal. One patient developed a spiculated mass, suspicious for carcinoma, that proved to be a cystic mass resulting from persistent serous effusion. The other patient demonstrated a large densely calcified capsule which interfered with breast imaging.

scholarly journals Unusual Case of Anaplastic Large Cell Lymphoma Presenting as a Breast Mass in a Patient with no History of Breast Implants

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Yana Ivashkevich ◽  
Yaroslav Chernov ◽  
Denis Chinenov ◽  
Evgeniy Shpot ◽  
Alexander A. Bessonov ◽  
...  
Keyword(s):  
Breast Tissue ◽  
Breast Implant ◽  
Malignant Neoplasm ◽  
Breast Implants ◽  
Large Cell ◽  
Breast Mass ◽  
Lower Percentage ◽  
Primary Lymphoma ◽  
Malignant Neoplasms ◽  
History Of

Adenocarcinoma is the most common malignant neoplasm involving breast tissue. In contrast to carcinomas, the other types of malignant neoplasms involving the breast are relatively uncommon. One of the examples of this rare entity is lymphoma. Traditionally, non-Hodgkin lymphomas (NHL) involving the breast are divided into primary lymphoma of the breast and systemic lymphoma, although the distinction could be challenging. Most of NHL involving breast tissue have B cell origin; T cell NHL represents less than 20% of all lymphoma cases. Anaplastic large cell lymphomas (ALCL) involving the breast accounts for even lower percentage of cases. Similar to ALCL involving other sites, there are several main types of ALCL identified: primary cutaneous ALCL and systemic ALCL, which is subdivided into ALK positive and ALK negative subtypes. Relatively recently, an additional distinct subtype of ALK-negative ALCL was described, which is associated with textured breast implants and needs to be considered as a differential diagnosis if patient has a history of breast implants. Here, we report a case of ALCL presented as a breast mass without history of breast implant and discuss similar cases published in the literature.

scholarly journals Comparison of BSGI, MRI, Mammography, and Ultrasound for the Diagnosis of Breast Lesions and Their Correlations with Specific Molecular Subtypes in Chinese Women.

2020 ◽  
Author(s):  
Hongbiao Liu ◽  
Hongwei Zhan ◽  
Da Sun ◽  
Ying Zhang
Keyword(s):  
Breast Cancer ◽  
Breast Imaging ◽  
Breast Tissue ◽  
Molecular Subtypes ◽  
Chinese Women ◽  
Imaging Modalities ◽  
Breast Lesions ◽  
Breast Cancer Patients ◽  
Diagnostic Efficacy ◽  
Molecular Breast Imaging

Abstract Background : Breast cancer is a leading cause of cancer in females, and is the second leading cancer-related cause of death in this group. Early diagnosis is essential to breast cancer to be effectively treated, and ultrasound, mammography, and MRI represent three key technologies that are utilized for the diagnosis of breast lesions. BSGI is an approach to molecular breast imaging that allows for high-resolution radio-imaging that is not adversely impacted by breast tissue density. This study was therefore designed to assess the relative diagnostic efficacy of BSGI, MRI, mammography, and ultrasound in different molecular subtypes of breast cancer among Chinese women. Methods : Diagnostic findings from 390 breast cancer patients that had undergone diagnosis and treatment in our breast surgery department were retrospectively reviewed. Patients had been diagnosed via BSGI, mammography, ultrasound, and MRI. The diagnostic efficacy of these different imaging modalities and their associated biological characteristics were compared in the present study. Results: A total of 229 of these 390 patients (58.7%) were diagnosed with malignant breast cancer, with the remaining 161 (41.3%) cases having been found to be benign. BSGI, MRI, mammography, and ultrasound yielded respective sensitivity values of 91.7%, 92.5%, 77.3%, and 82.1%, while the respective specificity values for these imaging modalities were 80.7%, 69.7%, 74.5%, and 70.8%. For lesions > 1 cm, BSGI offered a sensitivity of 92.5%, while for dense C and dense D breast tissue it yielded 91.5% and 89.3% sensitivity values, respectively, with these being similar to those achieved for dense A and dense B breast tissue (93.3% and 94.0%, respectively). BSGI also yielded a significantly higher LNR for malignant lesions relative to benign lesions (2.76±1.32 vs 1.46±0.49). Conclusions : These findings confirm that BSGI is highly sensitive and is superior to mammography in the detection and diagnosis of DCIS. Such diagnostic efficacy can be further improved by using BSGI as an auxiliary modality to mammography and ultrasound, potentially improving the reliability of breast lesion diagnosis, thereby ensuring that patients receive rapid and effective treatment without the risk of misdiagnosis or unnecessary surgical treatment.

scholarly journals Advances in Biomaterials for Breast Reconstruction

2021 ◽  
Vol 11 (16) ◽  
pp. 7493
Author(s):  
Jun-Ho Park ◽  
Ji-Ung Park ◽  
Hak Chang
Keyword(s):  
Breast Reconstruction ◽  
Breast Tissue ◽  
Breast Implant ◽  
Three Dimensional ◽  
Breast Implants ◽  
3D Bioprinting ◽  
Breast Enlargement ◽  
Liquid Type ◽  
The 1960S ◽  
Solid Implants

Breast cancer is one of the most commonly diagnosed malignancies in women. Along with increasing demands for breast reconstruction, the attention given to the psychological and aesthetic benefits of breast reconstruction has also increased. As breast reconstruction and augmentation demands increase, biomaterials for breast reconstruction are being developed, and the related industry is growing quickly worldwide. Among the various biomaterials used for breast enlargement, breast implants have undergone a remarkable evolution since the 1960s. Despite unsatisfactory results and unexpected complications, research dedicated to achieving an ideal breast implant has progressed. In accordance with attention to tissue engineering, a three-dimensional (3D) bioprinting technique for breast tissue regeneration has emerged to overcome the current limitations of breast biomaterials. Along with solid implants, injectable liquid-type fillers are also part of ongoing studies.

scholarly journals Intraoperative Assessment of Endogenous Microbiota in the Breast

2021 ◽  
Vol 43 (10) ◽  
pp. 759-764
Author(s):  
Henrique Stachon ◽  
Vanessa Amoroso ◽  
Cicero Urban ◽  
Pamela Bioni ◽  
Cleverton Spautz ◽  
...  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Breast Tissue ◽  
Breast Surgery ◽  
Breast Implant ◽  
Brain Heart Infusion ◽  
Breast Implants ◽  
Large Cell ◽  
Aeromonas Salmonicida ◽  
Staphylococcus Hominis ◽  
Near Future

Abstract Objective: Breast surgery is considered a clean surgery; however, the rates of infection range between 3 and 15%. The objective of the present study was to intraoperatively investigate the presence of autochthonous microbiota in the breast. Methods: Pieces of breast tissue collected from 49 patients who underwent elective breast surgery (reconstructive, diagnostic, or oncologic) were cultured. The pieces of breast tissue were approximately 1 cm in diameter and were removed from the retroareolar area, medial quadrant, and lateral quadrant. Each piece of tissue was incubated in brain heart infusion (BHI) broth for 7 days at 37°C, and in cases in which the medium became turbid due to microorganism growth, the samples were placed in Petri dishes for culturing and isolating strains and for identifying species using an automated counter. Results: Microorganism growth was observed in the samples of 10 of the 49 patients (20.4%) and in 11 of the 218 pieces of tissue (5%). The detected species were Staphylococcus lugdunensis, Staphylococcus hominis, Staphylococcus epidermidis, Sphingomonas paucimobilis, and Aeromonas salmonicida. No patient with positive samples had clinical infection postoperatively. Conclusion: The presence of these bacteria in breast tissue in approximately 20% of the patients in this series suggests that breast surgery should be considered a potential source of contamination that may have implications for adverse reactions to breast implants and should be studied in the near future for their oncological implications in breast implant-associated large-cell lymphoma etiology.

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