Ensemble of Deep Convolutional Neural Networks for Classification of Early Barrett’s Neoplasia Using Volumetric Laser Endomicroscopy

Barrett’s esopaghagus (BE) is a known precursor of esophageal adenocarcinoma (EAC). Patients with BE undergo regular surveillance to early detect stages of EAC. Volumetric laser endomicroscopy (VLE) is a novel technology incorporating a second-generation form of optical coherence tomography and is capable of imaging the inner tissue layers of the esophagus over a 6 cm length scan. However, interpretation of full VLE scans is still a challenge for human observers. In this work, we train an ensemble of deep convolutional neural networks to detect neoplasia in 45 BE patients, using a dataset of images acquired with VLE in a multi-center study. We achieve an area under the receiver operating characteristic curve (AUC) of 0.96 on the unseen test dataset and we compare our results with previous work done with VLE analysis, where only AUC of 0.90 was achieved via cross-validation on 18 BE patients. Our method for detecting neoplasia in BE patients facilitates future advances on patient treatment and provides clinicians with new assisting solutions to process and better understand VLE data.

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Ensemble of Deep Convolutional Neural Networks for Classification of Early Barrett's Neoplasia Using Volumetric Laser Endomicroscopy

10.20944/preprints201905.0244.v1 ◽

2019 ◽

Author(s):

Roger Fonollà ◽

Thom Scheeve ◽

Maarten R. Struyvenberg ◽

Wouter L. Curvers ◽

Albert J. de Groof ◽

...

Keyword(s):

Neural Networks ◽

Convolutional Neural Networks ◽

Multicenter Study ◽

Patient Treatment ◽

Deep Convolutional Neural Networks ◽

Test Dataset ◽

Novel Technology ◽

Vle Data ◽

Work Done

Barrett's esopaghagus (BE) is a known precursor of esophageal adenocarcinoma (EAC). Patients with BE undergo regular surveillance to early detect stages of EAC. Volumetric laser endomicroscopy (VLE) is a novel technology capable of imaging the inner tissue layers of the esophagus over a 6-cm length scan. However, interpretation of full VLE scans is still a challenge for human observers. In this work, we train an ensemble of deep convolutional neural networks to detect neoplasia in BE patients, using a dataset of images acquired with VLE in a multicenter study. We achieve values of AUC=$0.96$ on the unseen test dataset and we compare our results with previous work done with VLE analysis. Our method for detecting neoplasia in BE patients facilitates future advances on patient treatment and provides clinicians with new assisting solutions to process and better understand VLE data.

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CNN-based Classification of Degraded Images

Electronic Imaging ◽

10.2352/issn.2470-1173.2020.10.ipas-028 ◽

2020 ◽

Vol 2020 (10) ◽

pp. 28-1-28-7 ◽

Cited By ~ 1

Author(s):

Kazuki Endo ◽

Masayuki Tanaka ◽

Masatoshi Okutomi

Keyword(s):

Neural Networks ◽

Image Restoration ◽

Image Classification ◽

Convolutional Neural Networks ◽

Deep Convolutional Neural Networks ◽

Alternative Approach ◽

Degraded Image ◽

Degraded Images ◽

Straightforward Approach

Classification of degraded images is very important in practice because images are usually degraded by compression, noise, blurring, etc. Nevertheless, most of the research in image classification only focuses on clean images without any degradation. Some papers have already proposed deep convolutional neural networks composed of an image restoration network and a classification network to classify degraded images. This paper proposes an alternative approach in which we use a degraded image and an additional degradation parameter for classification. The proposed classification network has two inputs which are the degraded image and the degradation parameter. The estimation network of degradation parameters is also incorporated if degradation parameters of degraded images are unknown. The experimental results showed that the proposed method outperforms a straightforward approach where the classification network is trained with degraded images only.

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