scholarly journals Reduction in Indoor Airborne Endotoxin Concentration by the Use of Air Purifier and Its Relationship with Respiratory Health: A Randomized Crossover Intervention Study

Atmosphere ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 1523
Author(s):  
Yoshiko Yoda ◽  
Kenji Tamura ◽  
Naruhito Otani ◽  
Hideki Hasunuma ◽  
Shoji F. Nakayama ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Pulmonary Function ◽  
Healthy Subjects ◽  
Intervention Study ◽  
Respiratory Health ◽  
Geometric Mean ◽  
Household Characteristics ◽  
Endotoxin Concentration ◽  
Air Purifier ◽  
Household Members

Endotoxins are biological components of particulate matter that cause adverse respiratory system effects. Recently, air purifiers have been widely used; however, their effects on endotoxins are not fully understood. We conducted a randomized crossover intervention study to evaluate the effects of air purifiers on indoor endotoxins and occupants’ respiratory health. Thirty-two healthy subjects were randomly assigned to two groups; each group spent four weeks using either a true or sham (filter removed) air purifier. Subsequently, the subjects spent an additional four weeks using the alternative air purifier. The indoor endotoxins in fine (PM2.5) and coarse (PM10–2.5) particulate matter were continuously collected, and pulmonary function was tested repeatedly during the study period. Household characteristics were assessed using a questionnaire. The geometric mean of the PM2.5 endotoxin concentrations was 0.13 EU/m3, which was significantly lower with true purifiers compared with sham purifiers, after adjusting for household characteristics (0.17 EU/m3). In addition, the PM2.5 endotoxin concentrations were significantly greater in reinforced concrete houses than in wooden houses. The PM10–2.5 endotoxin concentrations were significantly greater in homes with two or more household members, and in those with pets. No association was found between endotoxin concentration and respiratory health among the subjects.

scholarly journals Effects of the Use of Air Purifier on Indoor Environment and Respiratory System among Healthy Adults

2020 ◽  
Vol 17 (10) ◽  
pp. 3687
Author(s):  
Yoshiko Yoda ◽  
Kenji Tamura ◽  
Sho Adachi ◽  
Naruhito Otani ◽  
Shoji F. Nakayama ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Pulmonary Function ◽  
Respiratory Health ◽  
Fine Particulate Matter ◽  
Forced Expiratory Volume ◽  
Healthy Adults ◽  
Air Purification ◽  
Aerodynamic Diameter ◽  
Air Purifier ◽  
Indoor Pm2.5

Air purifiers have become popular among ordinary families. However, it remains controversial whether indoor air purification improves the respiratory health of healthy adults. A randomized crossover intervention study was conducted with 32 healthy individuals. The subjects were categorized into two groups. One group continuously used true air purifiers, and the other followed with sham air purifiers for 4 weeks. Following this first intervention, all the subjects underwent a 4-week washout period and continued with the second 4-week intervention with the alternate air purifiers. We collected fine particulate matter (PM) ≤ 2.5 µm in aerodynamic diameter (PM2.5), coarse particulate matter between 2.5 and 10 µm in aerodynamic diameter (PM10–2.5) and ozone (O3). The subjects’ pulmonary function and fractional exhaled nitric oxide (FeNO) were measured during the study period. The indoor PM2.5 concentrations decreased by 11% with the true air purifiers compared to those with sham air purifiers. However, this decrease was not significant (p = 0.08). The air purification did not significantly improve the pulmonary function of the study subjects. In contrast, an increase in the indoor PM10–2.5 and O3 concentration led to a significant decrease in the forced expiratory volume in one second (FEV1.0)/forced vital capacity (FVC) and maximal mid-expiratory flow (MMEF), respectively. In conclusion, air purification slightly improved the indoor PM2.5 concentrations in ordinary homes but had no demonstrable impact on improving health.

scholarly journals Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine‐1 Trial)

2021 ◽  
pp. 2100139
Author(s):  
Ivan Cruz‐Chamorro ◽  
Nuria Álvarez‐Sánchez ◽  
Ana Isabel Álvarez‐Ríos ◽  
Guillermo Santos‐Sánchez ◽  
Justo Pedroche ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Intervention Study ◽  
Protein Hydrolysates ◽  
Safety And Efficacy ◽  
Lipid Status

scholarly journals Seasonal Changes in Lung Function in a Farming Population

2000 ◽  
Vol 7 (4) ◽  
pp. 320-325 ◽  
Author(s):  
Ambikaipakan Senthilselvan ◽  
James A Dosman ◽  
Karen M Semchuk ◽  
Helen H McDuffie ◽  
Allan J Cessna ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Seasonal Changes ◽  
Pesticide Exposure ◽  
Respiratory Health ◽  
Longitudinal Design ◽  
Winter Season ◽  
Occupational Exposures ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Farm Residents

OBJECTIVE:To assess the changes in respiratory health from winter to summer seasons in a rural population.DESIGN:A longitudinal design was used in the study.SETTING:A population-based study was conducted as part of the Environmental Pesticide Exposure and Human Health component of the Prairie Ecosystem Study (PECOS) in southwestern Saskatchewan.PATIENTS:In the winter season, 358 patients participated in the study. Of these patients, 234 returned for the second assessment during the summer season. After excluding 34 children aged 17 years and under, 200 adult patients were available for analysis.MEASUREMENTS:Questionnaires were used to obtain information on demographic factors, smoking habits, occupational and environmental exposures, and respiratory conditions. Pulmonary function measurements were obtained using a volume displacement spirometer.RESULTS:Mean ages (± SD) of the 106 men and 94 women participating in the study were 50.1±13.3 and 49.0±13.1 years, respectively. Mean percentage changes in maximal midexpiratory flow rate from winter to summer assessments indicated an improvement for town residents and a decline for farm residents. Mean percentage changes in the ratio of forced expiratory volume in 1 s to forced vital capacity indicated an improvement for town residents who were not engaged in farming, and increasing declines for town residents engaged in farming, farm residents not engaged in farming and farm residents engaged in farming.CONCLUSIONS:Seasonal changes occurred in measurements of pulmonary function between winter and summer seasons; these changes may be related to the environmental or occupational exposures experienced by the participants during the study.

Total viable molds and fungal DNA in classrooms and association with respiratory health and pulmonary function of European schoolchildren

2011 ◽  
Vol 22 (8) ◽  
pp. 843-852 ◽  
Author(s):  
Marzia Simoni ◽  
Gui-Hong Cai ◽  
Dan Norback ◽  
Isabella Annesi-Maesano ◽  
François Lavaud ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Respiratory Health ◽  
Fungal Dna

Particulate Matter Composition and Respiratory Health

Epidemiology ◽  
2015 ◽  
Vol 26 (3) ◽  
pp. 300-309 ◽  
Author(s):  
Ulrike Gehring ◽  
Rob Beelen ◽  
Marloes Eeftens ◽  
Gerard Hoek ◽  
Kees de Hoogh ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Respiratory Health

Particulate matter and airborne endotoxin concentration in calf barns and their association with lung consolidation, inflammation, and infection

2021 ◽  
Vol 104 (5) ◽  
pp. 5932-5947
Author(s):  
K. van Leenen ◽  
J. Jouret ◽  
P. Demeyer ◽  
P. Vermeir ◽  
D. Leenknecht ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Endotoxin Concentration ◽  
Lung Consolidation

Abstract 455: Assessment of Pharmacokinetic Drug-drug Interaction between LCZ696 and Hydrochlorothiazide

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Hsiu-Ling Hsiao ◽  
Michael Greeley ◽  
Parasar Pal ◽  
Thomas Langenickel ◽  
Gangadhar Sunkara ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Upper Bound ◽  
Healthy Subjects ◽  
Geometric Mean ◽  
Systemic Exposure ◽  
Compartmental Analysis ◽  
Angiotensin Receptor ◽  
Open Label ◽  
Neprilysin Inhibitor ◽  
Drug Drug Interaction

Objective: LCZ696 is a first-in-class angiotensin receptor neprilysin inhibitor (ARNI) being developed for the treatment of cardiovascular diseases, including hypertension and heart failure. Ingestion of LCZ696 results in systemic exposure to AHU377 (inactive prodrug of LBQ657, a neprilysin inhibitor) and valsartan (angiotensin receptor blocker). Hydrochlorothiazide (HCTZ) is indicated as first line treatment of hypertension. Since LCZ696 and HCTZ may be co-administered for optimal blood pressure control, this study was conducted to evaluate the pharmacokinetic (PK) drug-drug interaction potential between LCZ696 and HCTZ. Methods: An open-label, three-period, single sequence study in 27 healthy subjects was conducted. In Period 1, subjects received oral HCTZ 25 mg qd x 4 days and were discharged for a 4-10 day washout. In Period 2, subjects received LCZ696 400 mg qd x 5 days, and in Period 3, HCTZ 25 mg qd + LCZ696 400 mg qd x 4 days. Serial PK samples were collected and analyzed by a validated LC-MS/MS method. PK parameters (AUCtau,ss,Cmax,ss) of LCZ696 analytes (LBQ657, valsartan) and HCTZ in plasma were determined using non-compartmental analysis, and the results were statisticallyevaluated. Results: The 90% CIs confidence intervals (CIs) for the geometric mean ratio for AUCtau,ss of HCTZ fell within the ( 0.8 - 1.25) range, while those of Cmax,ss (0.74, 0.70-0.78) fell outside the range, indicating Cmax,ss of HCTZ decreased by 26% when co-administered with LCZ696. Those for AUCtau,ss of LBQ657 fell within the range but the upper bound for Cmax,ss (1.19, 1.10-1.28) was outside the range, indicating Cmax of LBQ657 increased by 19%; the upper bound for valsartan exposures(AUCtau,ss: 1.14, 1.00-1.29; Cmax,ss: 1.16, 0.98-1.37) were above the range, indicating AUCtau,ss and Cmax,ss of valsartan increased by 14%and 16%, respectively. Conclusion: When LCZ696 400mg qd and HCTZ 25mg qd were co- administered, AUCtau,ss of HCTZ was unchanged but Cmax,ss decreased by 26%; AUCtau,ss of LBQ657 was unchanged but Cmax,ss increased by 19%; and lastly, AUCtau,ss and Cmax,ss of valsartan increased by 14%and 16%, respectively. LCZ696 400 mg qd was safe and well tolerated in healthy subjects when administered alone and in combination with HCTZ 25 mg qd.

scholarly journals Monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosis

2013 ◽  
Vol 71 (3) ◽  
pp. 146-152 ◽  
Author(s):  
Guilherme Fregonezi ◽  
Palomma Russelly Saldanha Araújo ◽  
Tathiana Lindemberg Ferreira Macêdo ◽  
Mario Emilio Dourado Junior ◽  
Vanessa Regiane Resqueti ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Muscle Strength ◽  
Early Diagnosis ◽  
Pulmonary Function ◽  
Healthy Subjects ◽  
Respiratory Muscle ◽  
Function Evaluation ◽  
Respiratory Muscle Strength ◽  
Respiratory Dysfunction ◽  
Lateral Sclerosis

ObjectiveIt was study the relationship between respiratory muscle strength and forced vital capacity (FVC) in patients with amyotrophic lateral sclerosis (ALS) versus healthy subjects.MethodsPulmonary function and respiratory muscle strength [maximal inspiratory (PImax), maximal expiratory (PEmax) and sniff nasal inspiratory pressure (SNIP)] were assessed in patients with ALS and healthy subjects, matched using cutoffs established in the literature for impaired pulmonary function and respiratory muscle weakness.ResultsTwenty-eight ALS patients and 28 healthy subjects were studied. We found sensitivity and specificity for PImax, PEmax and SNIP of 75/58%, 81/67% and 75/67%. The Receiver Operating Characteristic curve (ROC curve) indicated that the variables PImax, PEmax and SNIP can identify differences in respiratory muscle strength between ALS and healthy individuals at 0.89, 0.9 and 0.82, respectively. A positive correlation was recorded between FVC (%) versus SNIP, PImax and PEmax.ConclusionIn ALS, monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of FVC.

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