scholarly journals Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer

2021 ◽  
Vol 9 (1) ◽  
pp. 5
Author(s):  
Maria K. Fedotova ◽  
Maksim N. Usachev ◽  
Ekaterina V. Bogdanova ◽  
Ekaterina Diachkova ◽  
Yuriy Vasil’ev ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Natural Compounds ◽  
Chlorin E6 ◽  
Related Impurities ◽  
Derivatives Of

To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis(dicarbollide) were synthesized. The conditions for the purification of compounds by HPLC were selected since the work with natural compounds is complicated by the production of closely related impurities.

Monitoring the encapsulation of chlorin e6 derivatives into polymer carriers by NMR spectroscopy

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1576-1586 ◽  
Author(s):  
Sara Pfister ◽  
Luca Sauser ◽  
Ilche Gjuroski ◽  
Julien Furrer ◽  
Martina Vermathen
Keyword(s):  
Relaxation Time ◽  
Nmr Spectroscopy ◽  
Core Region ◽  
Chlorin E6 ◽  
Polypropylene Glycol ◽  
Polymer Carriers ◽  
H Nmr ◽  
Line Shape Analysis ◽  
Dynamic Methods ◽  
Derivatives Of

The encapsulation of five derivatives of chlorin e6 with different hydrophobicity and aggregation properties into a series of five poloxamer-type triblock copolymer micelles (BCMs) with varying numbers of polyethylene and polypropylene glycol (PEG, PPG) units was monitored using 1H NMR spectroscopy. NMR chemical shift and line shape analysis, as well as dynamic methods including diffusion ordered spectroscopy (DOSY) and T1 and T2 relaxation time measurements of the chlorin and the polymer resonances, proved useful to assess the chlorin–BCM compatibility. The poloxamers had high capability to break up aggregates formed by chlorins up to intermediate hydrophobicity. Physically entrapped chlorins were always localized in the BCM core region. The loading capacity correlated with chlorin polarity for all poloxamers among which those with the lowest number of PPG units were most efficient. DOSY data revealed that relatively weakly aggregating chlorins partition between the aqueous bulk and micellar environment whereas more hydrophobic chlorins are well retained in the BCM core region, rendering these systems more stable. T1 and T2 relaxation time measurements indicated that motional freedom in the BCM core region contributes to encapsulation efficiency. The BCM corona dynamics were rather insensitive towards chlorin entrapment except for the poloxamers with short PEG chains. The presented data demonstrate that 1H NMR spectroscopy is a powerful complementary tool for probing the compatibility of porphyrinic compounds with polymeric carriers such as poloxamer BCMs, which is a prerequisite in the development of stable and highly efficient drug delivery systems suitable for medical applications like photodynamic therapy of tumors.

scholarly journals Photodynamic antibacterial action of guanidine and biguanidine derivatives of chlorin e6

2021 ◽  
Vol 27 (S1) ◽  
pp. 554-556
Author(s):  
Maria Sokolova ◽  
Anastasia Ignatova ◽  
Petr Ostroverkhov ◽  
Andrey Mironov ◽  
Mikhail Grin ◽  
...  
Keyword(s):  
Chlorin E6 ◽  
Antibacterial Action ◽  
Derivatives Of

THE SYNTHESIS OF C-9 MODIFIED DERIVATIVES OF THE α-METHYL GLYCOSIDE OF KDN METHYL ESTER

2001 ◽  
Vol 20 (2) ◽  
pp. 227-238 ◽  
Author(s):  
Adele K. Norton ◽  
Gaik B. Kok ◽  
Mark von Itzstein
Keyword(s):  
Methyl Ester ◽  
Methyl Glycoside ◽  
Derivatives Of

Derivate des Benzo[1.3]dioxols, 431 Über Benzo [1.3] dioxolcarbonsäuren / Derivatives of 1,3-Benzodioxoles, 43 1,3-Benzodioxolecarboxylic Acids

1978 ◽  
Vol 33 (7-8) ◽  
pp. 465-471
Author(s):  
Franz Daliacker ◽  
Volker Mues ◽  
In-O Kim
Keyword(s):  
Carboxylic Acid ◽  
Methyl Ester ◽  
Benzoic Acid ◽  
Myristic Acid ◽  
Good Yield ◽  
Acid Ester ◽  
Acid Methyl Ester ◽  
Acid Methyl ◽  
Derivatives Of

Abstract We describe the possibilities of formation and preparation of the “natural” 1,3-benzodioxolecarboxylic acids 1, 2, 4, 6 b, and 7, already mentioned in literature. Myristic acid (3e) was prepared in good yield from 3-methoxy-4,5-dihydroxy-benzoic acid ester (3c) , which could be easily made from 3-methoxy-2,3-carbonyldioxy-benzoic acid methylester (3b). Myristicic acid methylester (3d) could be subjected to methylation and hydrolysis leading to 3e without any difficulties. 4.6-dimethoxy-1,3-benzodioxole-5-carboxylic acid (5b) was prepared in good yields by oxidation of 4,6-dimethoxy-1,3-benzodioxole-5-aldehyde (5a). 5.7-dimethoxy-1,3-benzodioxole-carboxylic acid (13f), one of the “unnatural” 1,3-benzodioxolecarboxylic acids, derivatives of o-ipiperonylic acid (8), was prepared from 5-amino-7-methoxy-1,3- benzodioxole-4carboxylic acid methyl ester (13b) by diazotisation, elimination of nitrogen, methylation, and hydrolysis. A comparison of our measured pkA-values showed the strongest acidity belonging to 5,6-dimethoxy-1,3-benzodioxole-4-carbocylic acid (11).

scholarly journals Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester

2016 ◽  
Vol 10 (1) ◽  
Author(s):  
Andreea-Teodora Pânzariu ◽  
Maria Apotrosoaei ◽  
Ioana Mirela Vasincu ◽  
Maria Drăgan ◽  
Sandra Constantin ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

Cationic derivatives of the plant resistance inducer benzo[1,2,3]thiadiazole-7-carbothioic acid S-methyl ester (BTH) as bifunctional ionic liquids

2014 ◽  
Vol 55 (25) ◽  
pp. 3565-3568 ◽  
Author(s):  
Marcin Smiglak ◽  
Rafał Kukawka ◽  
Piotr Lewandowski ◽  
Henryk Pospieszny
Keyword(s):  
Ionic Liquids ◽  
Methyl Ester ◽  
Plant Resistance ◽  
Derivatives Of

Proton magnetic resonance and mass spectrometric studies on derivatives of sodium 2-O-α-D-mannopyranosyl-D-glycerate and related compounds

1969 ◽  
Vol 47 (21) ◽  
pp. 4083-4086 ◽  
Author(s):  
J. N. C. Whyte
Keyword(s):  
Magnetic Resonance ◽  
Methyl Ester ◽  
Proton Magnetic Resonance ◽  
Mass Spectra ◽  
Red Alga ◽  
Mass Spectrometric ◽  
Derivatives Of ◽  
Related Compounds

The proton magnetic resonance (p.m.r.) and mass spectra of the methyl ester pentaacetate of sodium 2-O-α-D-mannopyranosyl-D-glycerate from the red alga Rhodomela larix are compared to those of related compounds to affirm the assigned structure.

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