Diagnostic Value of Conventional PET Parameters and Radiomic Features Extracted from 18F-FDG-PET/CT for Histologic Subtype Classification and Characterization of Lung Neuroendocrine Neoplasms

Aim: To evaluate if conventional Positron emission tomography (PET) parameters and radiomic features (RFs) extracted by 18F-FDG-PET/CT can differentiate among different histological subtypes of lung neuroendocrine neoplasms (Lu-NENs). Methods: Forty-four naïve-treatment patients on whom 18F-FDG-PET/CT was performed for histologically confirmed Lu-NEN (n = 46) were retrospectively included. Manual segmentation was performed by two operators allowing for extraction of four conventional PET parameters (SUVmax, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG)) and 41 RFs. Lu-NENs were classified into two groups: lung neuroendocrine tumors (Lu-NETs) vs. lung neuroendocrine carcinomas (Lu-NECs). Lu-NETs were classified according to histological subtypes (typical (TC)/atypical carcinoid (AC)), Ki67-level, and TNM staging. The least absolute shrink age and selection operator (LASSO) method was used to select the most predictive RFs for classification and Pearson correlation analysis was performed between conventional PET parameters and selected RFs. Results: PET parameters, in particular, SUVmax (area under the curve (AUC) = 0.91; cut-off = 5.16) were higher in Lu-NECs vs. Lu-NETs (p < 0.001). Among RFs, HISTO_Entropy_log10 was the most predictive (AUC = 0.90), but correlated with SUVmax/SUVmean (r = 0.95/r = 0.94, respectively). No statistical differences were found between conventional PET parameters and RFs (p > 0.05) and TC vs. AC classification. Conventional PET parameters were correlated with N+ status in Lu-NETs. Conclusion: In our study, conventional PET parameters were able to distinguish Lu-NECs from Lu-NETs, but not TC from AC. RFs did not provide additional information.

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Prognostic Value of 18F-FDG PET/CT in a Large Cohort of Patients with Advanced Metastatic Neuroendocrine Neoplasms Treated with Peptide Receptor Radionuclide Therapy

Journal of Nuclear Medicine ◽

10.2967/jnumed.119.241414 ◽

2020 ◽

Vol 61 (11) ◽

pp. 1560-1569 ◽

Cited By ~ 3

Author(s):

Jingjing Zhang ◽

Qingxing Liu ◽

Aviral Singh ◽

Christiane Schuchardt ◽

Harshad R. Kulkarni ◽

...

Keyword(s):

Fdg Pet ◽

Radionuclide Therapy ◽

Prognostic Value ◽

Peptide Receptor Radionuclide Therapy ◽

Large Cohort ◽

Neuroendocrine Neoplasms ◽

Peptide Receptor ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Clinical Application of 18F-AlF-NOTA-Octreotide PET/CT in Combination With 18F-FDG PET/CT for Imaging Neuroendocrine Neoplasms

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000002578 ◽

2019 ◽

Vol 44 (6) ◽

pp. 452-458 ◽

Cited By ~ 11

Author(s):

Tingting Long ◽

Nengan Yang ◽

Ming Zhou ◽

Dengming Chen ◽

Yulai Li ◽

...

Keyword(s):

Clinical Application ◽

Fdg Pet ◽

Neuroendocrine Neoplasms ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on 18F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma

Contrast Media & Molecular Imaging ◽

10.1155/2021/7191363 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Cheng-Peng Li ◽

Dao-Ning Liu ◽

Ni-Na Zhou ◽

Xiu-Yun Tian ◽

Zhen Wang ◽

...

Keyword(s):

Fdg Pet ◽

Imaging Modality ◽

Standardized Uptake Value ◽

High Sensitivity ◽

Roc Curves ◽

Histologic Subtype ◽

Retroperitoneal Liposarcoma ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

This study aimed to evaluate the usefulness of maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET/CT) in differentiating the subtypes and tumor grades of retroperitoneal liposarcoma (RPLS). The data of RPLS patients who underwent surgical resection from November 2013 to December 2019 at the sarcoma center of our institute were reviewed. The demographics, clinical features, and SUVmax of 84 patients who underwent preoperative 18F-FDG PET/CT scans were analyzed. Of these, 19 patients (22.6%) were with well-differentiated liposarcoma (WDLPS), 60 patients (71.4%) were with dedifferentiated liposarcoma (DDLPS), and 5 patients (6.0%) were with pleomorphic liposarcoma (PMLPS). The median SUVmax of WDLPS, DDLPS, and PMLPS groups was 2.8 (IQR: 1.9–3.2), 6.2 (IQR: 4.1–11.3), and 4.5 (IQR: 4.0–7.4). The ROC curve suggested 3.8 as an approximate cutoff value of SUVmax for distinguishing WDLPS and non-WDLPS (sensitivity = 0.769; specificity = 0.895). The median SUVmax for FNCLCC Grades 1, 2, and 3 of RPLS was 2.5 (IQR: 1.9–3.2), 4.5 (IQR: 3.2–6.7), and 9.0 (IQR: 6.0–13.3). The ROC curves suggest that SUVmax of ≤3.8 and >5.3 can be used for predicting FNCLCC Grades 1 and 3, respectively. The result showed that 18F-FDG PET/CT exhibited high sensitivity and specificity for identifying the subtypes and FNCLCC grades of RPLS. Additionally, 18F-FDG PET/CT might be a useful complementary imaging modality for guiding suitable biopsy location of RPLS.

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Diagnostic and Clinical Impact of 18F-FDG PET/CT in Staging and Restaging Soft-Tissue Sarcomas of the Extremities and Trunk: Mono-Institutional Retrospective Study of a Sarcoma Referral Center

Journal of Clinical Medicine ◽

10.3390/jcm9082549 ◽

2020 ◽

Vol 9 (8) ◽

pp. 2549

Author(s):

Alessio Annovazzi ◽

Sandra Rea ◽

Carmine Zoccali ◽

Rosa Sciuto ◽

Jacopo Baldi ◽

...

Keyword(s):

Computed Tomography ◽

Soft Tissue ◽

Fdg Pet ◽

Soft Tissue Sarcomas ◽

Emission Computed Tomography ◽

Therapy Planning ◽

Histologic Subtype ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Background: Soft-tissue sarcomas (STS) represent a wide heterogeneous class of rare tumors. The exact role 18F-fluorodeoxyglucose positron emission/computed tomography (18F-FDG PET/CT) in the evaluation of STS is not well established. The aim of the present study was to evaluate how the use of 18F-FDG PET/CT in STS could influence patient therapy planning, looking for a possible added value over computed tomography and magnetic resonance imaging—the most used modalities in the study of STS. Differences in SUVmax according to histologic subtype and tumor grade were also considered. Methods: a total of 345 consecutive 18F-FDG PET/CT scans performed for initial staging (n = 171) or for suspected disease relapse (n = 174) in 282 patients with STS extracted from the local Information System database were retrospectively reviewed. Results: 18F-FDG PET/CT altered therapy planning in 80 cases (16.4% for staging and 29.9% in restaging), both for disease upstaging (58.8%) and downstaging (41.2%) Conclusions: 18F-FDG PET/CT could significantly influence management of patients with STS, particularly for restaging.

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Retrospective audit of 957 consecutive 18F-FDG PET–CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma

Clinical Sarcoma Research ◽

10.1186/s13569-018-0095-9 ◽

2018 ◽

Vol 8 (1) ◽

Cited By ~ 19

Author(s):

Ruth E. Macpherson ◽

Sarah Pratap ◽

Helen Tyrrell ◽

Mehrdad Khonsari ◽

Shaun Wilson ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Fdg Pet ◽

Ct Scans ◽

Histological Subtypes ◽

Retrospective Audit ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Ct And Mri

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Metabolic tumor burden quantified on [18F]FDG PET/CT improves TNM staging of lung cancer patients

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-017-3789-y ◽

2017 ◽

Vol 44 (13) ◽

pp. 2169-2178 ◽

Cited By ~ 4

Author(s):

Paula Lapa ◽

Bárbara Oliveiros ◽

Margarida Marques ◽

Jorge Isidoro ◽

Filipe Caseiro Alves ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Fdg Pet ◽

Tnm Staging ◽

Tumor Burden ◽

Lung Cancer Patients ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Metabolic Tumor Burden

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18F-FDG PET/CT in a Case of Urothelial Carcinoma in the Urachus Presenting as Colon Cancer

Diagnostics ◽

10.3390/diagnostics12010031 ◽

2021 ◽

Vol 12 (1) ◽

pp. 31

Author(s):

Jeannette D. Andersen ◽

Knud Fabrin ◽

Astrid Petersen ◽

Helle D. Zacho

Keyword(s):

Urothelial Carcinoma ◽

Sigmoid Colon ◽

Fdg Pet ◽

Bladder Wall ◽

Urogenital Sinus ◽

Histologic Subtype ◽

Normal Bladder ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Urachal cancer arises from an embryologic remnant of the urogenital sinus and allantois and accounts for approximately 1% of bladder malignancies. The most encountered histologic subtype is adenocarcinoma. We present a 76-year-old man suspected to have an advanced sigmoid cancer infiltrating nearby organs. A supplemental 18F-FDG PET/CT showed high tracer uptake in a tumorous process coherent with the dome of the bladder wall involving the sigmoid colon. Cystoscopy revealed a normal bladder wall, except for a small edematous area in the anterior bladder. Biopsies from the sigmoid colon and transurethral resection from the bladder confirmed a urothelial carcinoma originating from the urachus.

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Prostate incidentaloma on 18F-fluorodeoxyglucose positron emission tomography: Diagnostic value of volumetric positron emission tomography parameters

Nuklearmedizin ◽

10.1055/a-1525-7607 ◽

2021 ◽

Author(s):

Özlem Şahin ◽

Buğra Kaya ◽

Zeynep Aydın ◽

Ahmet Eren Şen ◽

Mehmet Sinan İyisoy ◽

...

Keyword(s):

Positron Emission Tomography ◽

Fdg Pet ◽

Area Under The Curve ◽

Standardized Uptake Value ◽

Emission Tomography ◽

Clinical Value ◽

Positron Emission ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Abstract Objective To evaluate whether volumetric PET parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) contributed to maximum standardized uptake value (SUVmax) in predicting prostate carcinoma in the prostate incidentalomas (PI) in 18F-FDG PET/CT. Materials and methods This retrospective study comprised 107 patients with PI of 4723 male patients who had undergone 18F-FDG PET/CT. SUVmax and volumetric PET parameters of PIs were assessed. MTV and TLG were acquired with each SUV threshold as 2.5, 3.0, 3.5, 4.0, 4.5, and 5.0. Results The PI incidence was 2.3%, and the malignancy ratio of PI was 15.9%. According to further analysis results, 17 patients were in the malignant group, and 46 patients were in the benign group. Malignant PIs had higher SUVmax (10.6 vs. 6.4 and p<0.01), MTV (all p < 0.01) and TLG (all p < 0.01) than benign incidentalomas. All volumetric PET parameters had higher area under the curve (AUC) than SUVmax. SUVmax AUC was 0.835 [95% confidence interval (CI): 0.728–0.942]. MTV 2.5 and TLG 2.5 had the highest performance for predicting malignant PI.MTV2.5 AUC was 0.871 (95% CI: 0.775–0.968), and TLG2.5 AUC was 0.882 (95% CI: 0.797–0.967). Using TLG 2.5 greater than 29.8 as the cut-off point, the sensitivity and specificity for malignancy prediction were 94.1% and 82.6%, respectively. Conclusion In this study, in which the effectiveness of volumetric parameters in the diagnosis of PI was evaluated for the first time, it was shown that they could potentially have clinical value along with SUVmax.

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