scholarly journals Incidence of Autism Spectrum Disorder in Youths Affected by Gilles de la Tourette Syndrome Based on Data from a Large Single Italian Clinical Cohort

2020 ◽  
Vol 10 (11) ◽  
pp. 812
Author(s):  
Mariangela Gulisano ◽  
Rita Barone ◽  
Maria Rita Mosa ◽  
Maria Chiara Milana ◽  
Federica Saia ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Tourette Syndrome ◽  
Age Of Onset ◽  
Clinical Sample ◽  
Child And Adolescent ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Onset Age ◽  
Sex Distribution ◽  
Clinical Cohort

Gilles de la Tourette syndrome (GTS) and autism spectrum disorder (ASD) are etiologically related neurodevelopmental disorders with an onset age before 18 years and a reported comorbidity of 2.9–20%. The aim of the present study was to identify the incidence of ASD in a large clinical sample of individuals affected by GTS and to compare our results with previously reported incidences. We retrospectively analyzed clinical data (n = 1200) from January 2010 to March 2019 obtained from the outpatient Catania Tourette Clinic, part of the Child and Adolescent Neurology and Psychiatry of the Medical and Experimental Department of Catania University. We used internationally validated evaluation tools. The neuropsychological evaluation was carried out by an expert and a certificated team of child and adolescent neurologists, supervised by two expert child neurologists (R.R. and M.G.). We investigated 975 GTS-affected individuals of various socioeconomic levels aged 5–18 years, and 8.9% (n = 87) were affected by ASD. The incidence of GTS with ASD was significantly lower (p < 0.001) in children than in adolescents. No statistically significant differences were found in the sex distribution and age of onset of tics between individuals with GTS alone and those with GTS and ASD. The incidence of GTS and ASD comorbidity in this study was high, and this has several implications in terms of treatment and prognosis.

Profile of two hundred children with Autism Spectrum Disorder from a tertiary child and adolescent psychiatry centre

2017 ◽  
Vol 28 ◽  
pp. 51-56 ◽  
Author(s):  
John Vijay Sagar Kommu ◽  
Gayathri K.R. ◽  
Shoba Srinath ◽  
Satish Chandra Girimaji ◽  
Shekhar P. Seshadri ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Adolescent Psychiatry ◽  
Children With Autism ◽  
Child And Adolescent ◽  
Autism Spectrum ◽  
Child And Adolescent Psychiatry ◽  
Spectrum Disorder

scholarly journals The Co-Occurrence of Autism Spectrum Disorder in Children With ADHD

2017 ◽  
Vol 24 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Benjamin Zablotsky ◽  
Matthew D. Bramlett ◽  
Stephen J. Blumberg
Keyword(s):  
Autism Spectrum Disorder ◽  
Tourette Syndrome ◽  
National Survey ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Diagnosis And Treatment ◽  
Adhd Symptoms ◽  
Treatment Needs ◽  
Children With Adhd ◽  
Adhd Subtype

Objective: Children with ADHD frequently present with autism spectrum disorder (ASD) symptomatology, yet there is a notable gap in the treatment needs of this subpopulation, including whether the presence of ASD may be associated with more severe ADHD symptoms. Method: Data from the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome ( n = 2,464) were used to compare children diagnosed with ADHD and ASD with children with ADHD, but not ASD. Children were classified as needing treatment if it was received or their parents reported it was needed, but not received. Results: Approximately one in eight children currently diagnosed with ADHD was also diagnosed with ASD. Children diagnosed with both disorders had greater treatment needs, more co-occurring conditions, and were more likely to have a combined hyperactive/impulsive and inattentive ADHD subtype. Conclusion: These findings highlight the complexity of children diagnosed with both ADHD and ASD.

Hypothalamus-pituitary-adrenal-axis associations with self- vs. parental ratings of depression in boys with an autism spectrum disorder

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Vicki Bitsika ◽  
Christopher F. Sharpley ◽  
Nicholas M. Andronicos ◽  
Linda L. Agnew
Keyword(s):  
Autism Spectrum Disorder ◽  
Young People ◽  
Child And Adolescent ◽  
Autism Spectrum ◽  
Careful Consideration ◽  
Spectrum Disorder ◽  
Symptom Inventory ◽  
Reliable Assessment ◽  
Sleeping Problems ◽  
Parental Ratings

AbstractDepression can be a major comorbidity in young people with an autism spectrum disorder (ASD). Although there is an association between major depressive disorder (MDD) and cortisol concentrations in non-ASD children, relatively little is known about that relationship in children with an ASD, or whether there are development effects on the relationship. It is also unclear whether self-reports or parents’ reports of depression in these children are more closely associated with cortisol.Salivary cortisol from morning and afternoon, plus Child and Adolescent Symptom Inventory responses for MDD, were collected from a sample of 139 boys with an ASD. Parents of these boys also provided ratings of their sons on the Child and Adolescent Symptom Inventory for MDD.Afternoon cortisol was significantly correlated with total depression scores for younger boys but not for older boys. There were also significant differences between the parents’ and the boys’ ratings for five of the 10 MDD symptoms. Parents’ ratings of their sons’ MDD symptoms of irritability, feeling sad or depressed, and sleeping problems were significantly correlated with the boys’ cortisol concentrations. Both boys’ and their parents’ ratings for thoughts of death, feeling worthless, and concentration problems were significantly associated with the boys’ cortisol concentrations.A reliable assessment of MDD in young people with an ASD requires careful consideration of the relative validity of parents’ and children’s reports of the latter’s individual MDD symptomatology.

scholarly journals 6.25 Characterizing the Autism Spectrum Disorder–ADHD Phenotype: Measurement Structure and Invariance in a Clinical Sample

2021 ◽  
Vol 60 (10) ◽  
pp. S166
Author(s):  
Aneta Krakowski ◽  
Katherine Cost ◽  
Peter Szatmari ◽  
Evdokia Anagnostou ◽  
Jennifer Crosbie ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Clinical Sample ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Phenotype Measurement

Clinical and Genetic Profile of Autism Spectrum Disorder–Epilepsy (ASD-E) Phenotype: Two Sides of the Same Coin!

2020 ◽  
Vol 51 (6) ◽  
pp. 390-398 ◽  
Author(s):  
Sudhakar Karunakaran ◽  
Ramshekhar N. Menon ◽  
Sruthi S. Nair ◽  
S. Santhakumar ◽  
Muralidharan Nair ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Age Of Onset ◽  
Focal Epilepsy ◽  
Diagnostic Yield ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Chromosomal Microarray ◽  
Seizure Type ◽  
Epilepsy Syndrome ◽  
Genetic Profile

The clinical phenotype of autism spectrum disorder and epilepsy (ASD-E) is a common neurological presentation in various genetic disorders, irrespective of the underlying pathophysiological mechanisms. Here we describe the demographic and clinical profiles, coexistent neurological conditions, type of seizures, epilepsy syndrome, and EEG findings in 11 patients with ASD-E phenotype with proven genetic etiology. The commonest genetic abnormality noted was CDKL5 mutation (3), MECP2 mutation (2), and 1p36 deletion (2). The median age of onset of clinical seizures was 6 months (range, 10 days to 11 years). The most common seizure type was focal onset seizures with impaired awareness, observed in 7 (63.6%) patients followed by epileptic spasms in 4 (30.8%), generalized tonic-clonic and atonic seizures in 3 (27.3%) patients each and tonic seizures in 2 (18.2%) patients and myoclonic seizures in 1 (9.1%) patient. Focal and multifocal interictal epileptiform abnormalities were seen in 6 (54.6%) and 5 (45.5%) patients, respectively. Epileptic encephalopathy and focal epilepsy were seen in 7 (63.6%) and 4 (36.4%) patients, respectively. The diagnostic yield of genetic testing was 44% (11 of 25 patients) and when variants of unknown significance and metabolic defects were included, the yield increased to 60% (15 of 25 patients). We conclude that in patients with ASD-E phenotype with an underlying genetic basis, the clinical seizure type, epilepsy syndrome, and EEG patterns are variable. Next-generation exome sequencing and chromosomal microarray need to be considered in clinical practice as part of evaluation of children with ASD-E phenotype.

Sign in / Sign up

Export Citation Format

Share Document