scholarly journals Childhood Trauma, the Combination of MAO-A and COMT Genetic Polymorphisms and the Joy of Being Aggressive in Forensic Psychiatric Patients

2021 ◽  
Vol 11 (8) ◽  
pp. 1008
Author(s):  
Michael Fritz ◽  
Franziska Rösel ◽  
Hannah Dobler ◽  
Judith Streb ◽  
Manuela Dudeck
Keyword(s):  
Genetic Polymorphisms ◽  
Childhood Trauma ◽  
Childhood Maltreatment ◽  
Psychiatric Patients ◽  
Violent Behavior ◽  
Reactive Aggression ◽  
Forensic Psychiatric Patients ◽  
Mao A ◽  
Forensic Psychiatric ◽  
Violent Offenses

Aggression and violent offenses are common amongst forensic psychiatric patients. Notably, research distinguishes two motivationally distinct dimension of aggression–instrumental and reactive aggression. Instrumental aggression comprises of appetitive, goal-directed aggressive acts, whereas reactive aggression consists of affective, defensive violence with both their biological basis remaining largely unknown. Childhood trauma and functional genetic polymorphisms in catecholamines converting enzymes, such as mono-amino-oxidase A (MAO-A) and catechol-o-methyltransferase (COMT) have been suggested to augment an aggressive behavioral response in adulthood. However, it warrants clarification if these factors influence one or both types of aggression. Furthermore, it remains elusive, if having a combination of unfavorable enzyme genotypes and childhood maltreatment further increases violent behavior. Hence, we set out to address these questions in the current study. First, analysis revealed an overall marginally increased frequency of the unfavorable MAO-A genotype in the test population. Second, each gene polymorphisms together with a traumatic childhood significantly increased the AFAS (Appetitive and Facilitative Aggression Scale) scores for both reactive and appetitive aggression. Third, having a combination of both disadvantageous genotypes and a negative childhood served as a minor positive predictor for increased reactive aggression, but had a strong influence on the joy of being aggressive.

The role of psychosocial treatment in decreasing of future violence behavior risk in forensicly treated psychiatric patients

2011 ◽  
Vol 26 (S2) ◽  
pp. 783-783
Author(s):  
S. Jonovska ◽  
V.Š. Jengić ◽  
L. Safner ◽  
G. Bošković ◽  
S. Zudenigo
Keyword(s):  
Psychiatric Patients ◽  
Violent Behavior ◽  
Psychosocial Treatment ◽  
Violence Risk ◽  
Forensic Psychiatric Patients ◽  
Forensic Treatment ◽  
Aggression Questionnaire ◽  
Schizophrenic Group ◽  
Forensic Psychiatric ◽  
In The Beginning

The main aim of this study was to establish to what extent psychosocial treatment as a part of complex, multicomponent forensic treatment has an influence on decreasing of the future violence behavior risk in population of forensic psychiatric patients. We examinated 13 patients treated on Department of Forensic Psychiatry of Psychiatric Hospital Rab in Rab, Croatia. 9 of them were males and 4 of them females, 25–60 years of age, all of them were compulsory hospitalized because of committed criminal act connected with violent behavior. All of them have diagnosis of schizophrenic group of diseases with different duration of forensic treatment (from few months to few years). During 2010. all of them participated in psychosocial programe workshops once a week, for 6 months.MethodsViolence Risk Screening-10 (V-RISK-10), subjective measure of the programme chairmen performed in the beginning and in the end of the programme. The Aggression Questionnaire and Daily Spiritual Experience Scale as self-assesment scales were performed in the end of the programme. Results point on decreasing of V-RISK-10 results in the end of the programe in all participants. Interested observation was that mentioned results and those on self-assesment scales were not always been correlated positively. We also proved negative correlation between aggressivity and spirituality. As a conclusion, we have indications to believe that is real to expect that comining psychosocial treatment with targeted psuchopharmacological interventions could leed to decreasing the risk of future violent bihevior in forensicly treated psuchiatric patients.

Predictive validity of the Short-Term Assessment of Risk and Treatability for violent behavior in outpatient forensic psychiatric patients.

2015 ◽  
Vol 27 (2) ◽  
pp. 377-391 ◽  
Author(s):  
Nadine A. C. Troquete ◽  
Rob H. S. van den Brink ◽  
Harry Beintema ◽  
Tamara Mulder ◽  
Titus W. D. P. van Os ◽  
...  
Keyword(s):  
Predictive Validity ◽  
Psychiatric Patients ◽  
Violent Behavior ◽  
Short Term ◽  
Forensic Psychiatric Patients ◽  
Forensic Psychiatric

Forensic Psychiatric Patients’ Perspectives on Their Care: A Narrative View

2016 ◽  
Vol 54 (1) ◽  
pp. 64-73 ◽  
Author(s):  
Riitta Askola ◽  
Merja Nikkonen ◽  
Eija Paavilainen ◽  
Päivi Soininen ◽  
Hanna Putkonen ◽  
...  
Keyword(s):  
Psychiatric Patients ◽  
Forensic Psychiatric Patients ◽  
Forensic Psychiatric

scholarly journals Prediction of recidivism in a long-term follow-up of forensic psychiatric patients: Incremental effects of neuroimaging data

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0217127 ◽  
Author(s):  
Carl Delfin ◽  
Hedvig Krona ◽  
Peter Andiné ◽  
Erik Ryding ◽  
Märta Wallinius ◽  
...  
Keyword(s):  
Psychiatric Patients ◽  
Prediction Of Recidivism ◽  
Forensic Psychiatric Patients ◽  
Neuroimaging Data ◽  
Long Term Follow Up ◽  
Forensic Psychiatric

scholarly journals Housing Trajectories of Forensic Psychiatric Patients

2016 ◽  
Vol 34 (2-3) ◽  
pp. 352-365 ◽  
Author(s):  
Leila Salem ◽  
Anne G. Crocker ◽  
Yanick Charette ◽  
Christopher M. Earls ◽  
Tonia L. Nicholls ◽  
...  
Keyword(s):  
Psychiatric Patients ◽  
Forensic Psychiatric Patients ◽  
Forensic Psychiatric ◽  
Housing Trajectories

Augmentation of clozapine with amisulpride: an effective therapeutic strategy for violent treatment-resistant schizophrenia patients in a UK high-security hospital

CNS Spectrums ◽  
2013 ◽  
Vol 19 (5) ◽  
pp. 403-410 ◽  
Author(s):  
James E. Hotham ◽  
Patrick J. D. Simpson ◽  
Rosalie S. Brooman-White ◽  
Amlan Basu ◽  
Callum C. Ross ◽  
...  
Keyword(s):  
Clinical Improvement ◽  
Psychiatric Patients ◽  
Case Series ◽  
Metabolic Parameters ◽  
Treatment Resistant ◽  
High Security ◽  
Forensic Psychiatric Patients ◽  
Before And After ◽  
History Of ◽  
Forensic Psychiatric

ObjectiveClozapine is used in the management of treatment-resistant schizophrenia and is effective in reducing aggression; however a subgroup of patients is poorly responsive. For violent patients in this group, there is limited literature on the use of strategies to augment clozapine with other agents. Here we present a case series of 6 schizophrenia patients, within a high-security hospital, who have a history of serious violence and who were treated with clozapine augmented with amisulpride.MethodsWe reviewed case notes and health records for evidence of violence/aggression and positive factors such as engagement in activities, and Clinical Global Impression (CGI) scores were formulated. We also examined metabolic parameters before and after augmentation.ResultsAll 6 of the patients showed clinical improvement in symptoms and a reduction in their risk of violence to others. Five patients had a reduction in number of violent/aggressive incidents, and all patients showed improvement in engagement in occupational, vocational, and/or psychological work. Metabolic parameters were largely unchanged except for 1 patient whose Body Mass Index (BMI) increased. Five patients reported side effects as unchanged or improved.ConclusionThese schizophrenia patients with a history of violence showed clinical improvement and reduced aggression and violence with amisulpride augmentation of clozapine. To our knowledge, this is the first report of an antiaggressive benefit of this combination in forensic psychiatric patients. Further studies are warranted to establish the efficacy and anti-aggressive effects of amisulpride augmentation of clozapine.

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