Fluorescence-Guided Surgery for Hepatoblastoma with Indocyanine Green

Fluorescence-guided surgery with indocyanine green (ICG) for malignant hepatic tumors has been gaining more attention with technical advancements. Since hepatoblastomas (HBs) possess similar features to hepatocellular carcinoma, fluorescence-guided surgery can be used for HBs, as aggressive surgical resection, even for distant metastases of HBs, often contributes positively to R0 (complete) resection and subsequent patient survival. Despite a few caveats, fluorescence-guided surgery allows for the more sensitive identification of lesions that may go undetected by conventional imaging or be invisible macroscopically. This leads to precise resection of distant metastatic tumors as well as primary liver tumors.

Download Full-text

Indocyanine green fluorescence guided surgery in primary and metastatic liver tumors: preliminary results from a single-center experience

HPB ◽

10.1016/j.hpb.2018.06.2987 ◽

2018 ◽

Vol 20 ◽

pp. S497-S498

Author(s):

G. Patania ◽

G. Impellizzeri ◽

S. Garritano ◽

M. Messina ◽

E. Sinagra ◽

...

Keyword(s):

Indocyanine Green ◽

Liver Tumors ◽

Single Center ◽

Green Fluorescence ◽

Indocyanine Green Fluorescence ◽

Guided Surgery ◽

Single Center Experience ◽

Fluorescence Guided Surgery ◽

Metastatic Liver Tumors ◽

Metastatic Liver

Download Full-text

NIR-II emissive AIEgen photosensitizers enable ultrasensitive imaging-guided surgery and phototherapy to fully inhibit orthotopic hepatic tumors

Journal of Nanobiotechnology ◽

10.1186/s12951-021-01168-w ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Ruizhen Jia ◽

Han Xu ◽

Chenlu Wang ◽

Lichao Su ◽

Jinpeng Jing ◽

...

Keyword(s):

Therapeutic Strategy ◽

Near Infrared ◽

Liver Tumors ◽

Early Stage ◽

Oxygen Species ◽

Hepatic Tumors ◽

Primary Liver Tumors ◽

Guided Surgery

AbstractAccurate diagnosis and effective treatment of primary liver tumors are of great significance, and optical imaging has been widely employed in clinical imaging-guided surgery for liver tumors. The second near-infrared window (NIR-II) emissive AIEgen photosensitizers have attracted a lot of attention with higher-resolution bioimaging and deeper penetration. NIR-II aggregation-induced emission-based luminogen (AIEgen) photosensitizers have better phototherapeutic effects and accuracy of the image-guided surgery/phototherapy. Herein, an NIR-II AIEgen phototheranostic dot was proposed for NIR-II imaging-guided resection surgery and phototherapy for orthotopic hepatic tumors. Compared with indocyanine green (ICG), the AIEgen dots showed bright and sharp NIR-II emission at 1250 nm, which extended to 1600 nm with high photostability. Moreover, the AIEgen dots efficiently generated reactive oxygen species (ROS) for photodynamic therapy. Investigations of orthotopic liver tumors in vitro and in vivo demonstrated that AIEgen dots could be employed both for imaging-guided tumor surgery of early-stage tumors and for ‘downstaging’ intention to reduce the size. Moreover, the therapeutic strategy induced complete inhibition of orthotopic tumors without recurrence and with few side effects. Graphical Abstract

Download Full-text