scholarly journals EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1632 ◽  
Author(s):  
Anthony Genna ◽  
Aline M. Vanwynsberghe ◽  
Amélie V. Villard ◽  
Charles Pottier ◽  
Julien Ancel ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Cancer Patient ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Crucial Role ◽  
Patient Management ◽  
The Road ◽  
Metastatic Colonization ◽  
On The Road ◽  
Early Phases

Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced ability to adapt to diverse microenvironments encountered during the metastatic spread. Accordingly, EMTs play a crucial role in the biology of circulating tumor cells (CTCs) and contribute to their heterogeneity. Here, we review major EMT-driven properties that may help hybrid Epithelial/Mesenchymal CTCs to survive in the bloodstream and accomplish early phases of metastatic colonization. We then discuss how interrogating EMT in CTCs as a companion biomarker could help refine cancer patient management, further supporting the relevance of CTCs in personalized medicine.

Detours on the Road to Personalized Medicine

JAMA ◽  
2011 ◽  
Vol 306 (17) ◽  
pp. 1914 ◽  
Author(s):  
Louis D. Fiore ◽  
Leonard William D’Avolio
Keyword(s):  
Personalized Medicine ◽  
The Road ◽  
On The Road

scholarly journals Circulating tumor cells promote the metastatic colonization of disseminated carcinoma cells by inducing systemic inflammation

Oncotarget ◽  
2017 ◽  
Vol 8 (17) ◽  
pp. 28418-28430 ◽  
Author(s):  
Yong-Chao Li ◽  
Jiu-Ming Zou ◽  
Chao Luo ◽  
Yu Shu ◽  
Jing Luo ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Systemic Inflammation ◽  
Carcinoma Cells ◽  
Metastatic Colonization

scholarly journals Circulating tumor cells count and characterization in a male breast cancer patient

2011 ◽  
Vol 12 (5) ◽  
pp. 379-382 ◽  
Author(s):  
Paola Gazzaniga ◽  
Giuseppe Naso ◽  
Cristina Raimondi ◽  
Angela Gradilone ◽  
Antonella Palazzo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Male Breast Cancer ◽  
Male Breast

scholarly journals Hurdles on the road to personalized medicine

2014 ◽  
Vol 9 (5) ◽  
pp. 935-939 ◽  
Author(s):  
Thomas Tursz ◽  
Rene Bernards
Keyword(s):  
Personalized Medicine ◽  
The Road ◽  
On The Road

Circulating Tumor Cells and Personalized Medicine

2021 ◽  
pp. 489-508
Author(s):  
Jin Sun Lee ◽  
Mark Jesus M. Magbanua ◽  
Marc R. Jabon ◽  
John W. Park
Keyword(s):  
Personalized Medicine ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
And Personalized Medicine

Therapeutic Dilemma in personalized medicine

2021 ◽  
Vol 16 ◽  
Author(s):  
Ehab S. EL Desoky
Keyword(s):  
Personalized Medicine ◽  
Gradual Change ◽  
Metabolizing Enzymes ◽  
The Road ◽  
Type2 Diabetes ◽  
Practice Of Medicine ◽  
Long Time ◽  
On The Road ◽  
The Individual ◽  
Oral Hypoglycemic Drugs

: The practice of medicine depends over a long time on identifying therapies that target an entire population. The increase in scientific knowledge over the years has led to the gradual change towards individualization and personalization of drug therapy. The hope of this change is to achieve a better clinical response to given medications and reduction of their adverse effects. Tailoring of medicine on the road of personalized medicine considers molecular and genetic mapping of the individual. However, many factors still impede the smooth application of personalized medicine and represent challenges or limitations in its achievement. In this article, we put some clinical examples that show dilemmas in the application of personalized medicine such as opioids in pain control, fluoropyrimidines in malignancy, clopidogrel as antiplatelet therapy and oral hypoglycemic drugs in Type2 diabetes in adults. Shaping the future of medicine through the application of personalized medicine for a particular patient needs to put into consideration many factors such as patient’s genetic makeup and life style, pathology of the disease and dynamic changes in its course as well as interactions between administered drugs and their effects on metabolizing enzymes. We hope in the coming years, the personalized medicine will foster changes in health care system in the way not only to treat patients but also to prevent diseases.

scholarly journals Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells

10.3791/53182 ◽  
2015 ◽  
Author(s):  
Estrelania S. Williams ◽  
Veronica Rodriquez-Bravo ◽  
Uma Chippada-Venkata ◽  
Janis De Ia Iglesia-Vicente ◽  
Yixuan Gong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patient ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Prostate Cancer Patient ◽  
Patient Derived Xenograft ◽  
Xenograft Models
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