scholarly journals Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1889
Author(s):  
Ulrich T. Hacker ◽  
Martin Bentler ◽  
Dorota Kaniowska ◽  
Michael Morgan ◽  
Hildegard Büning
Keyword(s):  
Gene Therapy ◽  
Large Scale ◽  
Safety Data ◽  
Cancer Gene Therapy ◽  
Data Availability ◽  
Current Status ◽  
Specific Gene ◽  
Scale Production ◽  
Cancer Gene ◽  
Adeno Associated Virus

Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery systems in gene therapy for inherited monogenetic diseases. First market approvals, excellent safety data, availability of large-scale production protocols, and the possibility to tailor the vector towards optimized and cell-type specific gene transfer offers to move from (ultra) rare to common diseases. Cancer, a major health burden for which novel therapeutic options are urgently needed, represents such a target. We here provide an up-to-date overview of the strategies which are currently developed for the use of AAV vectors in cancer gene therapy and discuss the perspectives for the future translation of these pre-clinical approaches into the clinic.

scholarly journals Adeno-associated virus-mediated cancer gene therapy: Current status

2015 ◽  
Vol 356 (2) ◽  
pp. 347-356 ◽  
Author(s):  
Jingfeng Luo ◽  
Yuxuan Luo ◽  
Jihong Sun ◽  
Yurong Zhou ◽  
Yajing Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Current Status ◽  
Cancer Gene ◽  
Adeno Associated Virus

scholarly journals Light-induced adenovirus gene transfer, an efficient and specific gene delivery technology for cancer gene therapy

2002 ◽  
Vol 9 (4) ◽  
pp. 365-371 ◽  
Author(s):  
Anders Høgset ◽  
Birgit Øvstebø Engesæter ◽  
Lina Prasmickaite ◽  
Kristian Berg ◽  
Øystein Fodstad ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Transfer ◽  
Gene Delivery ◽  
Cancer Gene Therapy ◽  
Specific Gene ◽  
Cancer Gene ◽  
Delivery Technology

scholarly journals Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor

2004 ◽  
Vol 12 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Gandham Mahendra ◽  
Sanjay Kumar ◽  
Tatyana Isayeva ◽  
Parameshwar J Mahasreshti ◽  
David T Curiel ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Tyrosine Kinase ◽  
Cancer Gene Therapy ◽  
Stable Expression ◽  
Cancer Gene ◽  
Adeno Associated Virus

scholarly journals Adeno-associated virus (AAV) vectors in cancer gene therapy

2016 ◽  
Vol 240 ◽  
pp. 287-301 ◽  
Author(s):  
Jorge L. Santiago-Ortiz ◽  
David V. Schaffer
Keyword(s):  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Adeno Associated Virus

scholarly journals Systemic Cancer Gene Therapy Using Adeno-associated Virus Type 1 Vector Expressing MDA-7/IL24

2007 ◽  
Vol 15 (10) ◽  
pp. 1805-1811 ◽  
Author(s):  
Ichiro Tahara ◽  
Koichi Miyake ◽  
Hideki Hanawa ◽  
Toshiyuki Kurai ◽  
Yukihiko Hirai ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Virus Type ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Adeno Associated Virus

scholarly journals Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy

2004 ◽  
Vol 64 (5) ◽  
pp. 1781-1787 ◽  
Author(s):  
Selvarangan Ponnazhagan ◽  
Gandham Mahendra ◽  
Sanjay Kumar ◽  
Denise R. Shaw ◽  
Cecil R. Stockard ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Adeno Associated Virus

scholarly journals Cancer Gene Therapy

2005 ◽  
Vol 4 (4) ◽  
pp. 315-330 ◽  
Author(s):  
Masato Yamamoto ◽  
David T. Curiel
Keyword(s):  
Gene Therapy ◽  
Clinical Trials ◽  
Continuous Infusion ◽  
Cancer Gene Therapy ◽  
Therapeutic Modality ◽  
Current Status ◽  
Cancer Gene ◽  
Gastrointestinal Cancers ◽  
Delivery Method ◽  
Promising Strategy

The prognosis of patients with some kinds of cancers whose patients are often found unresectable upon diagnosis is still dismal. In these fields, development of a new therapeutic modality is needed and gene therapy represents one promising strategy. So far, numerous cancer gene therapy clinical trials based on these principles have been carried out and have shown the safety of such modalities, but have fallen short of the initial expectations to cure cancers. In this review, we would like to make a problem-oriented discussion of current status of cancer gene therapy research by using mainly gastrointestinal cancers as an example. In order to overcome obstacles for full realization of cancer gene therapy, numerous researches have been conducted by many researchers. Various cancer-selective and non-selective genes, as well as lytic viruses themselves have been employed for gene therapy. In the context of gene delivery method, different kinds of viral and non-viral strategies have been utilized. In addition, surrogate assays, such as soluble markers and imaging, have been developed for safer and more informative clinical trials. Many experiments and clinical trials to date have figured out current obstacles for the realization of an effective cancer gene therapy modality. Tireless efforts to overcome such hurdles and continuous infusion of novel concepts into this field should lead to break through technologies and the cure of the patients.

238: Adeno-Associated Virus 2-Mediated Intratumoral Prostate Cancer Gene Therapy: Long-Term Maspin Expression Efficiently Suppresses Tumor Growth

2005 ◽  
Vol 173 (4S) ◽  
pp. 65-65
Author(s):  
Masami Watanabe ◽  
Yasutomo Nasu ◽  
Norihiro Kusumi ◽  
Atsushi Nagai ◽  
Hiromi Kumon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Tumor Growth ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Adeno Associated Virus ◽  
Maspin Expression
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