scholarly journals Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2374
Author(s):  
Koji Matsuo ◽  
Kazuhiro Tanabe ◽  
Masaru Hayashi ◽  
Masae Ikeda ◽  
Miwa Yasaka ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Diagnostic Performance ◽  
Screening Tool ◽  
Early Stage ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Spectra Analysis ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis

Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early stage epithelial ovarian cancer.

scholarly journals Human epididymis protein 4 antigen‐autoantibody complexes complement cancer antigen 125 for detecting early‐stage ovarian cancer

Cancer ◽  
2019 ◽  
Vol 126 (4) ◽  
pp. 725-736 ◽  
Author(s):  
Wei‐Lei Yang ◽  
Zhen Lu ◽  
Jing Guo ◽  
Bryan M. Fellman ◽  
Jing Ning ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis ◽  
Early Stage Ovarian Cancer

scholarly journals Comparison of Serum Human Epididymis Protein 4 with Cancer Antigen 125 as a Tumor Marker in Patients with Malignant and Nonmalignant Diseases

2011 ◽  
Vol 57 (11) ◽  
pp. 1534-1544 ◽  
Author(s):  
Jose M Escudero ◽  
Jose M Auge ◽  
Xavier Filella ◽  
Aureli Torne ◽  
Jaume Pahisa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Marker ◽  
Ca 125 ◽  
Malignant Diseases ◽  
Healthy Individuals ◽  
Cancer Antigen 125 ◽  
Benign Diseases ◽  
Cancer Antigen ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis

BACKGROUND Human epididymis protein 4 (HE4), a precursor of human epididymis protein, has been proposed as a tumor marker for ovarian cancer. We evaluated HE4 in comparison with cancer antigen 125 (CA 125) in healthy individuals and in patients with benign and malignant diseases. METHODS CA 125 and HE4 serum concentrations were determined in 101 healthy individuals, 535 patients with benign pathologies (292 with benign gynecologic diseases) and 423 patients with malignant diseases (127 with ovarian cancers). CA 125 and HE4 cutoffs were 35 kU/L and 140 pmol/L, respectively. RESULTS HE4 and CA 125 results were abnormal in 1.1% and 9.9% of healthy individuals and in 12.3% and 37% of patients with benign diseases, respectively. Renal failure was the most common cause of increased HE4 in patients with benign disease, who had significantly higher HE4 concentrations (P = 0.001) than patients with other benign diseases. HE4 showed a higher specificity than CA 125 in patients with benign gynecologic diseases, with abnormal concentrations in 1.3% and 33.2% of the patients, respectively. HE-4 concentrations were abnormal primarily in gynecologic cancer and lung cancer. By contrast, CA 125 was increased in many different nonovarian malignancies, including nonepithelial tumors. A significantly higher area under the ROC curve was obtained with HE4 than with CA 125 for differentiating benign from malignant diseases (0.755 vs 0.643) and in the differential diagnosis of gynecologic diseases (0.874 vs 0.722). CONCLUSIONS HE4 has significantly higher diagnostic specificity than CA 125, and the combination of CA 125 and HE4 improved the detection of ovarian cancer in all stages and histological types.

Predictive value of serum human epididymis protein 4 and cancer antigen 125 concentrations in endometrial carcinoma

2013 ◽  
Vol 209 (2) ◽  
pp. 142.e1-142.e6 ◽  
Author(s):  
Sami K. Saarelainen ◽  
Nina Peltonen ◽  
Terho Lehtimäki ◽  
Antti Perheentupa ◽  
Maarit H. Vuento ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Predictive Value ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis
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