scholarly journals The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1026
Author(s):  
Kazuhiro Okumura ◽  
Megumi Saito ◽  
Eriko Isogai ◽  
Yuichi Wakabayashi
Keyword(s):  
Mouse Strain ◽  
Inbred Mouse ◽  
Embryonic Stem ◽  
Bac Library ◽  
Inbred Mouse Strain ◽  
Wild Mouse ◽  
Artificial Chromosome ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Genetic Traits

MSM/Ms is a unique inbred mouse strain derived from the Japanese wild mouse, Mus musculus molossinus, which has been approximately 1 million years genetically distant from standard inbred mouse strains mainly derived from M. m. domesticus. Due to its genetic divergence, MSM/Ms has been broadly used in linkage studies. A bacterial artificial chromosome (BAC) library was constructed for the MSM/Ms genome, and sequence analysis of the MSM/Ms genome showed approximately 1% of nucleotides differed from those in the commonly used inbred mouse strain, C57BL/6J. Therefore, MSM/Ms mice are thought to be useful for functional genome studies. MSM/Ms mice show unique characteristics of phenotypes, including its smaller body size, resistance to high-fat-diet-induced diabetes, high locomotive activity, and resistance to age-onset hearing loss, inflammation, and tumorigenesis, which are distinct from those of common inbred mouse strains. Furthermore, ES (Embryonic Stem) cell lines established from MSM/Ms allow the MSM/Ms genome to be genetically manipulated. Therefore, genomic and phenotypic analyses of MSM/Ms reveal novel insights into gene functions that were previously not obtained from research on common laboratory strains. Tumorigenesis-related MSM/Ms-specific genetic traits have been intensively investigated in Japan. Furthermore, radiation-induced thymic lymphomas and chemically-induced skin tumors have been extensively examined using MSM/Ms.

scholarly journals THE Ah PHENOTYPE. SURVEY OF FORTY-EIGHT RAT STRAINS AND TWENTY INBRED MOUSE STRAINS

Genetics ◽  
1982 ◽  
Vol 100 (1) ◽  
pp. 79-87
Author(s):  
Daniel W Nebert ◽  
Nancy M Jensen ◽  
Hisashi Shinozuka ◽  
Heinz W Kunz ◽  
Thomas J Gill
Keyword(s):  
Specific Activity ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Mouse Strains ◽  
Ah Receptor ◽  
Inbred Mouse Strains ◽  
Sprague Dawley ◽  
Rat Strains ◽  
Specific Activities ◽  
Inbred Rat

ABSTRACT Forty-four inbred and four randombred rat strains and 20 inbred mouse strains were examined for their Ah phenotype by determining the induction of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity (EC 1.14.14.1) by intraperitoneal treatment with either β-naphthoflavone or 3-methylcholanthrene. All 48 rat strains were found to be Ah-responsive. The maximally induced hydroxylase specific activities of the ALB/Pit, MNR/Pit, MR/Pit, SHR/Pit, and Sprague-Dawley strains were of the same order of magnitude as the basal hydroxylase specific activities of the ACI/Pit, F344/Pit, OKA/Pit, and MNR/N strains. Six of the 20 mouse strains were Ah-nonresponsive (i.e. lacking the normal induction response and presumably lacking detectable amounts of the Ah receptor). The basal hydroxylase specific activities of the BDL/N, NFS/N, STAR/N, and ST/JN mouse strains were more than twice as high as the maximally induced hydroxylase specific activity of the CBA/HT strain.——To date, 24 Ah-nonresponsive mouse strains have been identified, out of a total of 68 known to have been characterized. The reasons for not finding a single Ah-nonresponsive inbred rat strain—as compared with about one Ah-nonresponsive inbred mouse strain found for every three examined—remain unknown.

Endotoxin sensitivity of inbred mouse strains

1973 ◽  
Vol 19 (7) ◽  
pp. 767-769 ◽  
Author(s):  
Stephen I. Vas ◽  
Raymond S. Roy ◽  
Hugh G. Robson
Keyword(s):  
Mouse Strain ◽  
Inbred Mouse ◽  
Toxic Effects ◽  
Mouse Strains ◽  
Inbred Mouse Strains

Inbred mouse strains show characteristic susceptibility to S. typhimurium infections. The sensitivity of the same strains to endotoxin is not parallel. While C3H/He J and C57B1/6J mice were highly susceptible to infection they showed more resistance to purified endotoxin than A/J, a mouse strain relatively resistant to infection. These findings suggest that the death of mice during S. typhimurium infection is not due only to toxic effects of its lipopolysaccharide.

Improved Generation of Germline-Competent Embryonic Stem Cell Lines from Inbred Mouse Strains

Stem Cells ◽  
2003 ◽  
Vol 21 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Luc Schoonjans ◽  
Veerle Kreemers ◽  
Sophie Danloy ◽  
Randall W. Moreadith ◽  
Yves Laroche ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Cell Lines ◽  
Inbred Mouse ◽  
Embryonic Stem ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Stem Cell Lines

scholarly journals Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

2012 ◽  
Vol 23 (9-10) ◽  
pp. 680-692 ◽  
Author(s):  
Anatole Ghazalpour ◽  
Christoph D. Rau ◽  
Charles R. Farber ◽  
Brian J. Bennett ◽  
Luz D. Orozco ◽  
...  
Keyword(s):  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Genetic Traits ◽  
Hybrid Mouse ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel

scholarly journals Analysis of Structural Variation Among Inbred Mouse Strains Identifies Genetic Factors for Autism-Related Traits

2021 ◽  
Author(s):  
Ahmed Arslan ◽  
Zhuoqing Fang ◽  
Meiyue Wang ◽  
Zhuanfen Cheng ◽  
Boyoung Yoo ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Sequence Data ◽  
Inbred Mouse ◽  
Inbred Strains ◽  
Autism Spectrum ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Genetic Traits ◽  
Long Read ◽  
Short Read Sequence

AbstractThe genomes of six inbred strains were analyzed using long read (LR) sequencing. The results revealed that structural variants (SV) were very abundant within the genome of inbred mouse strains (4.8 per gene), which indicates that they could impact genetic traits. Analysis of the relationship between SNP and SV alleles across 53 inbred strains indicated that we have a very limited ability to infer whether SV are present using short read sequence data, even when nearby SNP alleles are known. The benefit of having a more complete map of the pattern of genetic variation was demonstrated by identifying at least three genetic factors that could underlie the unique neuroanatomic and behavioral features of BTBR mice that resemble human Autism Spectrum Disorder (ASD). Similar to the genetic findings in human ASD cohorts, the identified BTBR-unique alleles are very rare, and they cause high impact changes in genes that play a role in neurodevelopment and brain function.

scholarly journals Generating Embryonic Stem Cells from the Inbred Mouse Strain DBA/2J, a Model of Glaucoma and Other Complex Diseases

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50081 ◽  
Author(s):  
Laura G. Reinholdt ◽  
Gareth R. Howell ◽  
Anne M. Czechanski ◽  
Danilo G. Macalinao ◽  
Katharine H. MacNicoll ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Mouse Strain ◽  
Inbred Mouse ◽  
Embryonic Stem ◽  
Inbred Mouse Strain ◽  
Complex Diseases

scholarly journals Comparative Evaluation of Two Vaccine Candidates against Experimental Leishmaniasis Due to Leishmania major Infection in Four Inbred Mouse Strains

2009 ◽  
Vol 16 (11) ◽  
pp. 1529-1537 ◽  
Author(s):  
Fouad Benhnini ◽  
Mehdi Chenik ◽  
Dhafer Laouini ◽  
Hechmi Louzir ◽  
Pierre André Cazenave ◽  
...  
Keyword(s):  
Mouse Strain ◽  
Leishmania Major ◽  
Inbred Mouse ◽  
Inbred Strains ◽  
Mouse Strains ◽  
Human Populations ◽  
Inbred Mouse Strains ◽  
Vaccine Candidates ◽  
Preclinical Evaluation ◽  
Protein Disulfide

ABSATRCT Experimental leishmaniasis in BALB/c and C57BL/6 mice are the most investigated murine models that were used for the preclinical evaluation of Leishmania vaccine candidates. We have previously described two new inbred mouse strains named PWK and MAI issued from feral founders that also support the development of experimental leishmaniasis due to L. major. In this study, we sought to determine whether different mouse inbred strains generate concordant or discordant results when used to evaluate the potential of Leishmania proteins to protect against experimental leishmaniasis. To this end, two Leishmania proteins, namely, LACK (for Leishmania homolog of receptor for activated C kinase) and LmPDI (for L. major protein disulfide isomerase) were compared for their capacity to protect against experimental leishmaniasis in PWK, MAI, BALB/c, and C57BL/6 inbred mouse strains. Our data show that the capacity of Leishmania proteins to confer protection depends on the mouse strain used, stressing the important role played by the genetic background in shaping the immune response against the pathogen. These results may have important implications for the preclinical evaluation of candidate Leishmania vaccines: rather than using a single mouse strain, a panel of different inbred strains of various genetic backgrounds should be tested in parallel. The antigen that confers protection in the larger range of inbred strains may have better chances to be also protective in outbred human populations and should be selected for clinical trials.

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