scholarly journals Future Prospects of Colorectal Cancer Screening: Characterizing Interval Cancers

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1328
Author(s):  
Gemma Ibáñez-Sanz ◽  
Rebeca Sanz-Pamplona ◽  
Montse Garcia ◽  
on behalf of the MSIC-SC Research Group
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Clinical Characteristics ◽  
Molecular Data ◽  
Screening Tests ◽  
Colorectal Cancers ◽  
Future Prospects ◽  
Interval Cancers ◽  
Molecular Features ◽  
Interval Colorectal Cancer

Tumors that are not detected by screening tests are known as interval cancers and are diagnosed clinically after a negative result in the screening episode but before the next screening invitation. Clinical characteristics associated with interval colorectal cancers have been studied, but few molecular data are available that describe interval colorectal cancers. A better understanding of the clinical and biological characteristics associated with interval colorectal cancer may provide new insights into how to prevent this disease more effectively. This review aimed to summarize the current literature concerning interval colorectal cancer and its epidemiological, clinical, and molecular features.

scholarly journals Effect of Financial Incentives on Patient Use of Mailed Colorectal Cancer Screening Tests

2019 ◽  
Vol 2 (3) ◽  
pp. e191156 ◽  
Author(s):  
Shivan J. Mehta ◽  
Rebecca S. Pepe ◽  
Nicole B. Gabler ◽  
Mounika Kanneganti ◽  
Catherine Reitz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Financial Incentives ◽  
Screening Tests ◽  
Cancer Screening Tests ◽  
Patient Use

EP.TU.660The rate of interval colorectal cancer within 5 years of a negative colonoscopy at a district general hospital

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Abdullah Alqallaf ◽  
Aimee Grant ◽  
Corina Lavelle ◽  
Palanichamy Chandran
Keyword(s):  
Colorectal Cancer ◽  
Short Interval ◽  
Interval Cancer ◽  
District General Hospital ◽  
Colorectal Cancers ◽  
Right Colon ◽  
Adenoma Detection ◽  
Technical Factors ◽  
Interval Colorectal Cancer ◽  
Repeat Procedures

Abstract Aims Interval colorectal cancer is defined as cancer that has developed within a short interval of a diagnostic test that did not detect a cancer. Many authors define this interval as five years, though more complex definitions of interval cancer have been proposed. Our aim was to determine what percentage of colorectal cancers diagnosed at our hospital had a negative colonoscopy within the 5 years prior to their diagnosis. Methods We obtained details of all colorectal cancers diagnosed between 2017-2019 at our department. We then surveyed the endoscopy system to detect the patients who had a negative colonoscopy within the 5 years prior to their diagnosis, to calculate what percentage of cancers diagnosed within that period were interval cancers. Results Between 2017-2019, 539 patients were diagnosed with colorectal cancer. Age at diagnosis varied widely from 21 to 107, and 310 (57.5%) of patients were male. Seventeen patients had a negative colonoscopy within 5 years (though two of these were planned repeat procedures within a few months of the index ‘negative’ colonoscopy). We can therefore calculate the rate of interval cancer at 3.1% between 2017-2019. Conclusions The aetiology of interval colorectal cancer has been attributed to patient/tumour factors (right colon and female sex) and technical factors (adenoma detection and caecal intubation rate). Though the rate of interval cancer at our department seems pleasingly low compared to the literature, we plan to investigate the risk factors that might be at play: are biological factors to blame or can our endoscopy service be improved?

scholarly journals Interval cancers after negative immunochemical test compared to screen and non-responders’ detected cancers in Slovenian colorectal cancer screening programme

2018 ◽  
Vol 52 (4) ◽  
pp. 413-421 ◽  
Author(s):  
Dominika Novak Mlakar ◽  
Tatjana Kofol Bric ◽  
Ana Lucija Škrjanec ◽  
Mateja Krajc
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Screening Test ◽  
Screening Programme ◽  
Interval Cancers ◽  
Faecal Immunochemical Test ◽  
Test Sensitivity ◽  
Cancer Screening Programme ◽  
Immunochemical Test

Abstract Background We assessed the incidence and characteristics of interval cancers after faecal immunochemical occult blood test and calculated the test sensitivity in Slovenian colorectal cancer screening programme. Patients and methods The analysis included the population aged between 50 to 69 years, which was invited for screening between April 2011 and December 2012. The persons were followed-up until the next foreseen invitation, in average for 2 years. The data on interval cancers and cancers in non-responders were obtained from cancer registry. Gender, age, years of schooling, the cancer site and stage were compared among three observed groups. We used the proportional incidence method to calculate the screening test sensitivity. Results Among 502,488 persons invited for screening, 493 cancers were detected after positive screening test, 79 interval cancers after negative faecal immunochemical test and 395 in non-responders. The proportion of interval cancers was 13.8%. Among the three observed groups cancers were more frequent in men (p = 0.009) and in persons aged 60+ years (p < 0.001). Comparing screen detected and cancers in non-responders with interval cancers more interval cancers were detected in persons with 10 years of schooling or more (p = 0.029 and p = 0.001), in stage III (p = 0.027) and IV (p < 0.001), and in right hemicolon (p < 0.001). Interval cancers were more frequently in stage I than non-responders cancers (p = 0.004). Test sensitivity of faecal immunochemical test was 88.45%. Conclusions Interval cancers in Slovenian screening programme were detected in expected proportions as in similar programmes. Test sensitivity was among the highest when compared to similar programmes and was accomplished using test kit for two stool samples.

scholarly journals Use of Colorectal Cancer Screening Tests by State

2018 ◽  
Vol 15 ◽  
Author(s):  
Djenaba A. Joseph ◽  
Jessica B. King ◽  
Thomas B. Richards ◽  
Cheryll C. Thomas ◽  
Lisa C. Richardson
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Screening Tests ◽  
Cancer Screening Tests

When to Stop Screening: A Review of Breast, Gynecologic, and Colorectal Cancer Screening in Women Over Age 65

2010 ◽  
Vol 11 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Rebecca Bernstein ◽  
Daniel Dejoseph ◽  
Edward M. Buchanan
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Task Force ◽  
The United States ◽  
Screening Tests ◽  
Women Patients ◽  
Cancer Society ◽  
Screening Guidelines ◽  
Health Goals ◽  
Current Screening

Because age alone is not an indicator of health, there is no clear consensus among the various cancer screening guidelines on when to stop cancer screening. For breast, cervical, and colorectal cancer, there are recommended screening tests, while, for other gynecologic cancers, there are not. When discussing with older women patients when to stop cancer screening, we encourage practitioners to review the goals of the screening test, assess the health and functional status of the patient, and discuss her values and health goals. To facilitate this discussion, we review proposed frameworks for determining when to screen older patients for cancer. We also review the concepts of “well” and “frail” older adults. Finally, we review the current screening recommendations for breast, gynecological, and colorectal cancers, and the reasoning behind them, from the United States Preventative Screening Task Force, the American Cancer Society, the American College of Obstetricians and Gynecologists, and the American Geriatric Society.

Level and Factors Associated with Participation in PopulationBased Cancer Screening in Safranbolu District of Karabuk, Turkey

2020 ◽  
Author(s):  
Raziye ÖZDEMIR ◽  
Fatma TÜRKMEN ÇEVIK ◽  
Duygu KES ◽  
Merve KARACALI ◽  
Simge ÖZGÜNER
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Cervical Cancer ◽  
Cancer Screening ◽  
Fold Increase ◽  
Population Based ◽  
Colorectal Cancers ◽  
Binary Logistic Regression Model ◽  
Cross Sectional ◽  
Factors Associated

Background: Cervix, breast and colorectal cancers are included in the national population-based screening (PBS) program in Turkey. This study aimed to assess participation in PBSs for these cancers and to identify factors associated with participation in screenings in Safranbolu district of Karabuk, Turkey in 2016-2017. Methods: In this cross-sectional study, separate studying groups for cervix, breast and colorectal cancers were identified, taking into account the target age range specified in the national screening standards. The sample size was determined to be 374 for cervical cancer, 371 for breast cancer and 373 for colorectal cancer in the Epi-Info StatCalc program with a prevalence of 50%, a 95% Confidence Interval (CI) and a 5% error margin. The results of the data collected through face-to-face interview using questionnaires were evaluated with Chisquare tests (P<0.05) and included in the binary logistic regression model. Results: Participation in PBS at least once between 2011 and 2016 years was 26.2% for cervical cancer, 27.6% for breast cancer and 31.6% for colorectal cancer, whereas the level of PBS or opportunistic screening at least once was 51.1%, 42.7% and 32.2%, respectively. A 2.9-fold increase in participation for the cervical cancer screening was associated with informing women about cervical cancer by the family physicians. Being married and living in the district center showed associations with a higher rate of participation for colorectal cancer screening. Conclusion: Participation in PBS was low for the 5.5-year period. More effort is needed to increase the effectiveness of the program.

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