scholarly journals One-Pot Synthesis of 7, 7-Dimethyl-4-Phenyl-2-Thioxo-2,3,4,6,7, 8-Hexahydro-1H-Quinazoline-5-OnesUsing Zinc Ferrite Nanocatalyst and Its Bio Evaluation

Catalysts ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 431
Author(s):  
Tentu Nageswara Rao ◽  
Nalla Krishnarao ◽  
Faheem Ahmed ◽  
Suliman Yousef Alomar ◽  
Fadwa Albalawi ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Zinc Ferrite ◽  
Large Scale ◽  
Cyano Group ◽  
Proton Nuclear Magnetic Resonance ◽  
Scale Production ◽  
One Pot ◽  
Antibacterial And Antifungal ◽  
Nuclear Magnetic

A simple and highly efficient protocol for the synthesis of derivatives 7, 7-dimethyl-4-phenyl-2-thioxo-2, 3, 4, 6, 7, 8-hexahydro-1H-quinazoline-5-one from 5, 5-dimethyl cyclohexane-1, 3-dione (4a–4h) (dimedone) has been described. The aryl aldehydes were substituted with thiourea in the presence of synthesized zinc ferrite nanocatalyst, which increased the yield under reflux through condensation, followed by cyclization to give desired products. The other advantages are that it is eco-friendly and economically affordable for large-scale production. Structural validation and characterization of all the newly synthesized compounds were evaluated by spectral analysis (mass spectrometry, proton nuclear magnetic resonance (1HNMR), and Carbon-13 nuclear magnetic resonance(13CNMR)spectroscopies. The structure of antibacterial and antifungal assays was performed with the newly synthesized compounds. The antimicrobial activity of title compounds possessing electron-withdrawing groups such as (4e–4h) (Cl, Br, and cyano group) exhibited more active potential than the electron-donating groups, C6H5,4-C6H4, 3-OC2H5-4OH-C6H3, etc., (4a–4d) containing moiety.

scholarly journals Ethyl 1-butyl-2-(2-hydroxy-4-methoxyphenyl)-1H-benzo[d]imidazole-5-carboxylate

Molbank ◽  
10.3390/m1192 ◽  
2021 ◽  
Vol 2021 (1) ◽  
pp. M1192
Author(s):  
Reshma Sathyanarayana ◽  
Boja Poojary
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Molecular Electrostatic Potential ◽  
Emission Spectra ◽  
Sodium Dithionite ◽  
Proton Nuclear Magnetic Resonance ◽  
One Pot ◽  
Ft Ir ◽  
Fourier Transfer Infrared Spectroscopy ◽  
Nuclear Magnetic

Ethyl 4-(butylamino)-3-nitrobenzoate upon “one-pot” nitro-reductive cyclization using sodium dithionite and substituted aldehyde in dimethyl sulphoxide affords ethyl 1-butyl-2-(2-hydroxy-4-methoxyphenyl)-1H-benzo[d]imidazole-5-carboxylate in an 87% yield. The structural characterization was determined by Fourier-transfer infrared spectroscopy (FT-IR), Proton nuclear magnetic resonance (1H-NMR) , Carbon-13 nuclear magnetic resonance (13C-NMR), mass spectrometry, Ultraviolet-visible(UV-Vis), photoluminescence (PL), thin-film solid emission spectra, cyclic voltammetry (CV) and thermogravimetric (TGA) analysis. Molecular electrostatic potential (MEP) was studied to determine the reactive sites of the molecule.

scholarly journals Design, Synthesis, Characterization, Biological Activity and ADME Study of New 5-arylidene-4-Thiazolidinones Derivatives Having

2019 ◽  
pp. 77-88
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Chloroacetic Acid ◽  
13C Nmr Spectroscopy ◽  
Proton Nuclear Magnetic Resonance ◽  
Design Synthesis ◽  
Antibacterial And Antifungal ◽  
Adme Study ◽  
Nuclear Magnetic

New series of Nabumetone containing 5-arylidene-4-thiazolidinones pharmacophore as in compounds 3(a-e) were designed and synthesized by using nabumetone and hydrazinethiocarboamide to synthesize compound (1) (Schiff base), next step compound (1) will react with chloroacetic acid and anhydrous sodium acetate in order to synthesize compound (2) containing 4-thiazolidinone ring this compound will react with 4-benzaldehyde derivatives in the presence of basic media such as piperidine to form compounds 3(a-e). The structures of new intermediate and final synthesized compounds were detected by determination of physical properties (melting points). The structure of synthesized compounds has been confirmed by FT-IR spectroscopy, proton nuclear magnetic resonance (1H-NMR) spectroscopy and carbon 13 nuclear magnetic resonance (13C-NMR) spectroscopy the final synthesized compounds were also screened for their antibacterial and antifungal activity.

scholarly journals “One-shot” analysis of wine parameters in non-Saccharomyces large-scale alcohol reduction processes with one- and two-dimensional nuclear magnetic resonance

2019 ◽  
Vol 15 ◽  
pp. 02016
Author(s):  
J.E. Herbert-Pucheta ◽  
C. Pino-Villar ◽  
F. Rodríguez-González ◽  
G. Padilla-Maya ◽  
D. Milmo-Brittingham ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Large Scale ◽  
Correlation Spectroscopy ◽  
Wine Industry ◽  
Proton Nuclear Magnetic Resonance ◽  
Resonance Spectroscopy ◽  
Two Dimensional ◽  
Alcohol Reduction ◽  
Nuclear Magnetic

Facing climate change in wine industry comprises the implementation of strategies, such as to reduce alcohol in wines, promoted by abnormal increment of sugar levels in wine grapes. The present work discusses the first industrial-scale use of specific yeast strains able to produce wine with reduced alcoholic concentration. Reduction of alcohol content and quantification of key metabolites associated to oenological practice and/or quality were simultaneously measured in a “one-shot” way with proton Nuclear Magnetic Resonance Spectroscopy. Novel relevant metabolites were revealed with the use of a two-dimensional 1H-13C HSQC multipresat correlation spectroscopy, whereas a detailed methodological NMR description is stressed, towards revealing novel resonances within the NMR signature. The use of multitask analytical methods to simultaneously describe alcohol reduction and NMR targeting, completes the portfolio of NMR solutions recently proposed to the World Organisation of Vine and Wine for as well quantify aging and varieties.

scholarly journals Design, synthesis and anticancer activity evaluation of aziridine-1,2,3-triazole hybrid derivatives

2018 ◽  
Vol 24 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Hong-Ru Dong ◽  
Jian-Guo Wu
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Proton Nuclear Magnetic Resonance ◽  
Human Leukemia ◽  
Anticancer Activities ◽  
One Pot ◽  
Design Synthesis ◽  
H Nmr ◽  
Highly Active ◽  
Nuclear Magnetic

AbstractNew 1-aryl-4-[(aziridine-1-yl)diarylmethyl]-5-methyl-1H-1,2,3-triazole derivatives7a–iwere synthesized by a one-pot reaction of diaryl-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)methanols6a–iderived from 1-aryl-5-methyl-1H-1,2,3-triazole-4-carboxylic acids4a–c. Structures of compounds7a–iwere confirmed by analysis of proton nuclear magnetic resonance (1H NMR) and carbon-13 nuclear magnetic resonance (13C NMR), mass spectrometry (MS) and infrared (IR) data. The structure of compound7fwas studied by X-ray diffraction analysis. The anticancer activities of compounds7a–iagainst human leukemia HL-60 cells and human hepatoma G2 cells were evaluated. Some of the compounds are highly active.

scholarly journals N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl] quinoline]-acetamide

Molbank ◽  
10.3390/m1213 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1213
Author(s):  
Paolo Coghi ◽  
Jerome P. L. Ng ◽  
Ali Adnan Nasim ◽  
Vincent Kam Wai Wong
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Quantum Coherence ◽  
Biologically Active ◽  
Proton Nuclear Magnetic Resonance ◽  
Dipolar Cycloaddition ◽  
Heteronuclear Single Quantum Coherence ◽  
Pharmacokinetic Properties ◽  
Nuclear Magnetic

The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of 4-azido-7-chloroquinoline with an alkyne derivative of acetaminophen. The compound was fully characterized by Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro with different normal and cancer cell lines. The drug likeness of the compound was also investigated by predicting its pharmacokinetic properties.

Sign in / Sign up

Export Citation Format

Share Document