scholarly journals Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2193
Author(s):  
Susanne Kristine Aune ◽  
Joanna Cwikiel ◽  
Arnljot Flaa ◽  
Harald Arnesen ◽  
Svein Solheim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Binding Protein ◽  
Exercise Stress ◽  
Strenuous Exercise ◽  
Temporary Increase ◽  
Fatty Acid Binding ◽  
Gut Leakage ◽  
Artery Disease

Elevated levels of gut leakage markers have been shown after strenuous exercise in healthy individuals. Any association between a temporary increase in these markers and the presence of coronary artery disease (CAD) is unknown. We therefore aimed to explore circulating gut leakage markers in response to a bout of strenuous exercise in patients with symptoms of CAD. Patients referred to exercise stress testing due to symptoms of CAD were included (n = 287). A maximal exercise ECG stress test was performed and venous blood samples were drawn at rest and within five minutes after, for analysis of soluble cluster of differentiation 14 (sCD14), lipopolysaccharide-binding protein (LBP), intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide (LPS) and gene expression of toll-like receptor 4 (TLR4) in circulating leukocytes. Patients then underwent coronary angiography. LPS, LBP and sCD14 increased significantly after strenuous exercise in patients with symptoms of CAD, suggesting that even short bouts of vigorous exercise are associated with gut leakage. The gene expression of TLR4 decreased significantly after exercise, possibly as a negative feedback to the increase in LPS. There were no differences in exercise-induced changes between the groups of CAD, suggesting gut leakage to be independent of the presence of CAD.

Heart type fatty acid binding protein in relation to pharmacologic scintigraphy in coronary artery disease

2012 ◽  
Vol 50 (2) ◽  
Author(s):  
Eftihia Sbarouni ◽  
Panagiota Georgiadou ◽  
Maria Koutelou ◽  
Mihas Constantinos ◽  
Antigoni Chaidaroglou ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acid ◽  
Coronary Artery ◽  
Stress Testing ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Serum Levels ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Artery Disease

AbstractHeart-type fatty acid-binding protein (H-FABP) is a marker of myocardial necrosis, but whether it increases during myocardial ischemia is not known. This study investigated whether serum levels of H-FABP change during adenosine stress testing and nuclear imaging in patients with stable coronary artery disease.Thirty stable patients with established coronary artery disease on their medications were studied. Sampling was performed before the stress test, at the end of adenosine infusion, as well as 1, 2 and 3 h after the completion of the infusion.No difference in H-FABP serum levels were found at the five pre-specified time points in the overall group (p=0.99); furthermore, there was no significant difference regardless of the test result – positive (p=1) or negative (p=0.98).It is concluded that H-FABP does not change significantly during pharmacologic stress testing in patients with known coronary artery disease and there is no difference whether there is inducible ischemia or not.

scholarly journals Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men

2011 ◽  
Vol 10 (1) ◽  
pp. 44 ◽  
Author(s):  
Masayuki Doi ◽  
Toru Miyoshi ◽  
Satoshi Hirohata ◽  
Kazufumi Nakamura ◽  
Shinichi Usui ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acid ◽  
Coronary Artery ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Elderly Men ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Artery Disease

scholarly journals Gut related inflammation and cardiorespiratory fitness in patients with CAD and type 2 diabetes: a sub-study of a randomized controlled trial on exercise training

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Susanne Kristine Aune ◽  
Rune Byrkjeland ◽  
Svein Solheim ◽  
Harald Arnesen ◽  
Marius Trøseid ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Exercise Training ◽  
Cardiorespiratory Fitness ◽  
Binding Protein ◽  
Gut Leakage ◽  
Artery Disease

Abstract Aim Gut leakage has been shown to associate with low-grade inflammation and lower cardiorespiratory fitness in diabetic subjects. We aimed to investigate whether gut leakage markers related to cardiorespiratory fitness in patients with both coronary artery disease and type 2 diabetes, and whether these were affected by long-term exercise training. Methods Patients with angiographically verified coronary artery disease and type 2 diabetes mellitus (n = 137) were randomized to either 12 months exercise intervention or conventional follow-up. A cardiopulmonary exercise test and fasting blood samples were obtained before and after intervention to assess VO2peak and the biomarkers soluble CD14, lipopolysaccharide-binding protein and intestinal fatty-acid binding protein as markers of gut leakage. Results 114 patients completed the intervention satisfactory. VO2peak correlated inversely to sCD14 (r = − 0.248, p = 0.004) at baseline. Dividing sCD14 into quartiles (Q), VO2peak was significantly higher in Q1 vs. Q2–4 (p = 0.001), and patients in Q2-4 (sCD14 > 1300 ng/mL) had an OR of 2.9 (95% CI 1.2–7.0) of having VO2peak below median (< 23.8 ml/kg/min) at baseline. There were no statistically significant differences in changes in gut leakage markers between the two randomized groups (all p > 0.05) after 12 months. Conclusions Cardiorespiratory fitness related inversely to sCD14, suggesting physical capacity to be associated with gut leakage in patients with CAD and T2DM. Long-term exercise training did not affect circulating gut leakage markers in our population. Trial registration NCT01232608, Registered 02 November 2010—Retrospectively registered at https://clinicaltrials.gov/ct2/show/NCT01232608?term=NCT01232608&draw=2&rank=1

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