scholarly journals Therapeutic Success in Swiss COPD Patients Receiving Dual Bronchodilation Therapy as COPD Maintenance Treatment

2022 ◽  
Vol 12 (1) ◽  
pp. 46-56
Author(s):  
Marc Spielmanns ◽  
Sebastian Schildge ◽  
Jens Peter Diedrich ◽  
Arschang Valipour
Keyword(s):  
Maintenance Treatment ◽  
Demographic Data ◽  
Symptom Burden ◽  
Chronic Obstructive ◽  
Therapeutic Success ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Dual Bronchodilation ◽  
Related Quality ◽  
Copd Maintenance

Health-related quality of life (HRQoL) in patients with moderate to severe chronic obstructive pulmonary disease (COPD) is often reduced by high symptom burden and frequent exacerbations. So far, data on therapeutic success in Swiss COPD patients receiving dual bronchodilation therapy as COPD maintenance treatment are limited. Data from a recently published, non-interventional study on clinical benefit after the start of combined tiotropium–olodaterol treatment were analyzed focusing on Swiss patients compared to the overall cohort including patients from various European countries. Demographic data on the changes in Clinical COPD Questionnaire (CCQ) for the assessment of HRQoL in correlation to symptoms and the number of exacerbations, as well as physician’s global assessment (PGE), were evaluated 6 weeks after treatment start. In Switzerland (n = 61), significantly more patients had comorbidities and exacerbations but showed less symptoms compared to the overall cohort (n = 4639). HRQoL improved in both cohorts, with a negative correlation to symptom burden and number of exacerbations in the overall cohort. PGE scores improved after 6 weeks with a better general condition at baseline in Swiss patients (PGE score 4/5: 68.9% [Swiss cohort] vs. 49.0% [overall cohort]. Despite significant differences regarding the presence of symptoms and exacerbations, therapeutic success was similar in both patient groups. Highly symptomatic patients benefited mostly from tiotropium–olodaterol treatment.

scholarly journals Clinical significance in COPD patients followed in a real practice

2013 ◽  
Vol 8 ◽  
Author(s):  
Júlio César Mendes de Oliveira ◽  
Isabella De Carvalho Aguiar ◽  
Ana Carolina Negrinho de Oliveira Beloto ◽  
Israel Reis Santos ◽  
Fernando Sergio Studart Leitão Filho ◽  
...  
Keyword(s):  
Demographic Data ◽  
Public Health Issue ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Sputum Production ◽  
Related Quality ◽  
Health Related ◽  
History Of ◽  
Real Practice

Background: Chronic obstructive pulmonary disease (COPD) is an important public health issue in many countries which is estimated to become the fifth cause of disability and the third cause of mortality in the world within 2020. The objective of this study was to identify the clinical characteristics in the real clinical practice of a sample of patients with COPD followed in a pulmonology clinic. Methods: The initial sample contained 207 subjects with respiratory claims that searched for specialized treatment and initiated regular monitoring between 2004 and 2009 in a private clinic localized in Cascavel, in the state of Parana, Brazil. Demographic data (weight, height, body mass index - BMI), history of comorbidities, use of respiratory and non respiratory drugs were also registered. Results: The main cause related to the development of COPD was current or prior smoking (92.0%); the most frequently reported symptom was dyspnea (95.0%), followed by cough (86.1%), wheezing (69.4%) and sputum production (40.0%). During the follow up, 51 patients developed the need for oxygen therapy (28.3%). In 96 patients, there were periods of acute exacerbation, resulting in 37 hospitalizations. In addition to COPD, a significant number of comorbidities were identified, being cardiovascular disease and neurological disorders the most prevalent ones. Conclusions: Based on the data collected, we could outline the profile of patients with COPD, showing characteristics of an elderly population, with multiple comorbidities, suggesting a health related quality of life lower than expected.

Comparison of end-of-life care in people with chronic obstructive pulmonary disease or lung cancer: A systematic review

2020 ◽  
Vol 34 (8) ◽  
pp. 1030-1043 ◽  
Author(s):  
Stacey J Butler ◽  
Lauren Ellerton ◽  
Andrea S Gershon ◽  
Roger S Goldstein ◽  
Dina Brooks
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Palliative Care ◽  
Pulmonary Disease ◽  
Symptom Burden ◽  
Chronic Obstructive ◽  
Health Related Quality ◽  
Obstructive Pulmonary Disease ◽  
Related Quality ◽  
Health Related

Background: Palliative care has been widely implemented in clinical practice for patients with cancer but is not routinely provided to people with chronic obstructive pulmonary disease. Aim: The study aims were to compare palliative care services, medications, life-sustaining interventions, place of death, symptom burden and health-related quality of life among chronic obstructive pulmonary disease and lung cancer populations. Design: Systematic review with meta-analysis (PROSPERO: CRD42019139425). Data sources: MEDLINE, EMBASE, PubMed, CINAHL and PsycINFO were searched for studies comparing palliative care, symptom burden or health-related quality of life among chronic obstructive pulmonary disease, lung cancer or populations with both conditions. Quality scores were assigned using the QualSyst tool. Results: Nineteen studies were included. There was significant heterogeneity in study design and sample size. A random effects meta-analysis ( n = 3–7) determined that people with lung cancer had higher odds of receiving hospital (odds ratio: 9.95, 95% confidence interval: 6.37–15.55, p < 0.001) or home-based palliative care (8.79, 6.76–11.43, p < 0.001), opioids (4.76, 1.87–12.11, p = 0.001), sedatives (2.03, 1.78–2.32, p < 0.001) and dying at home (1.47, 1.14–1.89, p = 0.003) compared to people with chronic obstructive pulmonary disease. People with lung cancer had lower odds of receiving invasive ventilation (0.26, 0.22–0.32, p < 0.001), non-invasive ventilation (0.63, 0.44–0.89, p = 0.009), cardiopulmonary resuscitation (0.29, 0.18–0.47, p < 0.001) or dying at a nursing home/long-term care facility (0.32, 0.16–0.64, p < 0.001) than people with chronic obstructive pulmonary disease. Symptom burden and health-related quality of life were relatively similar between the two populations. Conclusion: People with chronic obstructive pulmonary disease receive less palliative measures at the end of life compared to people with lung cancer, despite a relatively similar symptom profile.

scholarly journals Health-Related Quality Of Life, Uncertainty, ‎and Anxiety among Patients with Chronic Obstructive Pulmonary Disease

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 420
Author(s):  
Nazih Abu Tabar ◽  
Mohammad Al Qadire ◽  
Imad Thultheen ◽  
Jafar Alshraideh
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Chronic Obstructive ◽  
Health Related Quality ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Related Quality ◽  
Health Related ◽  
The Mean

Patients’ with Chronic Obstructive Pulmonary Disease suffer from serious respiratory symptoms that increase anxiety, stress, and uncertainty, and affect quality of life. The aim of this study was to assess level of anxiety, uncertainty, and health related quality of life (HRQoL) among COPD patients in Jordan. Correlational cross-sectional survey design was used to collect data from 153 COPD patients. ‎The study was conducted at pulmonary clinics in three major referral hospitals in Jordan that provide care for COPD patients from different parts of the country. To assess HRQoL, St. George ‎Respiratory Questionnaire‎ was completed. Uncertainty and anxiety level was measured by Mishel's uncertainty of illness scale and state anxiety inventory respectively. The mean age of participants was 66.8 (SD= 10.3) and most participants were males (94.1%) with. The mean score of HRQoL was 57.9 (SD = 20.5). The mean score of participants’ level of anxiety was 38.1 (SD = 11.1). The mean score of uncertainty was 66.1 (SD= 11.1). There is a statistically significant positive relationship between HRQoL and anxiety (r =.433, p< .01), and uncertainty (r=.483, p<.01). Increased anxiety and uncertainty among COPD patients was associated with low HRQoL. Health care providers need to pay attention the effect of anxiety and uncertainty on COPD patients’ quality of life and institute appropriate management.

scholarly journals Osteoporosis in Chronic obstructive Pulmonary Disease (COPD) Patients

2018 ◽  
Vol 19 (2) ◽  
pp. 114-118
Author(s):  
Md Khairul Islam ◽  
Fahima Sharmin Hossain ◽  
Mostofa Kamal Chowdhury ◽  
Prodip Kumar Biswas
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Complete Blood Count ◽  
Demographic Data ◽  
Smoking History ◽  
Chronic Obstructive ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease ◽  
X Ray ◽  
Copd Patients

Background: Osteoporosis is one of the most common systemic features of Chronic obstructive pulmonary disease (COPD). But there had been no data regarding osteoporosis in COPD patients in Bangladesh. Objectives: To determine the frequency of osteoporosis in COPD patients.Materials & Methods: This was a cross sectional observational study. COPD patients were recruited from Sarkari kormachari hospital. Patients were excluded if they had asthma, any disease affecting bones and calcium homeostasis or were receiving drugs related to bone metabolism. Demographic data were collected including age, smoking history, inhaled corticosteroid use, body mass index, treatment history hospital admission. Chest x-ray was done to exclude any infection or malignancy. Blood was obtained for complete blood count, renal function test, CRP. Bone mineral density (BMD; g/cm2) was conducted by using dual energy x-ray absorptiometry scan (DXA scan) at second to fourth lumbar spines (L2-4) and femoral neck.Results: The overall prevalence of osteoporosis according to the lowest T-score at either L2-4 or femoral neck were 56.7%. This is very high than other country. BMI and CRP were significantly associated with osteoporosis.Conclusion: The frequency of osteoporosis in Bangladeshi COPD patients was higher than others. Osteoporosis was associated with low BMI and high level of CRP.J MEDICINE JUL 2018; 19 (2) : 114-118

scholarly journals Dual bronchodilation with tiotropium/olodaterol further reduces activity-related breathlessness versus tiotropium alone in COPD

2019 ◽  
Vol 53 (3) ◽  
pp. 1802049 ◽  
Author(s):  
François Maltais ◽  
Joseph-Leon Aumann ◽  
Anne-Marie Kirsten ◽  
Éric Nadreau ◽  
Hemani Macesic ◽  
...  
Keyword(s):  
Chronic Obstructive ◽  
Borg Scale ◽  
Double Blind ◽  
Obstructive Pulmonary Disease ◽  
Lung Hyperinflation ◽  
Copd Patients ◽  
Pulmonary Impairment ◽  
Dual Bronchodilation ◽  
Reducing Activity ◽  
Reduced Activity

The 3-min constant speed shuttle test (CSST) was used to examine the effect of tiotropium/olodaterol compared with tiotropium at reducing activity-related breathlessness in patients with chronic obstructive pulmonary disease (COPD).This was a randomised, double-blind, two-period crossover study including COPD patients with moderate to severe pulmonary impairment, lung hyperinflation at rest and a Mahler Baseline Dyspnoea Index <8. Patients received 6 weeks of tiotropium/olodaterol 5/5 µg and tiotropium 5 µg in a randomised order with a 3-week washout period. The speed for the 3-min CSST was determined for each patient such that an intensity of breathing discomfort ≥4 (“somewhat severe”) on the modified Borg scale was reached at the end of a completed 3-min CSST.After 6 weeks, there was a decrease in the intensity of breathlessness (Borg dyspnoea score) at the end of the 3-min CSST from baseline with both tiotropium (mean –0.968, 95% CI −1.238– −0.698; n=100) and tiotropium/olodaterol (mean −1.325, 95% CI −1.594– −1.056; n=101). The decrease in breathlessness was statistically significantly greater with tiotropium/olodaterol versus tiotropium (treatment difference −0.357, 95% CI −0.661– −0.053; p=0.0217).Tiotropium/olodaterol reduced activity-related breathlessness more than tiotropium in dyspnoeic patients with moderate to severe COPD exhibiting lung hyperinflation.

Assessment of health-related quality of life in end-stage chronic obstructive pulmonary disease and non-small-cell lung cancer patients in Serbia

2015 ◽  
Vol 14 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Dragana Maric ◽  
Dragana Jovanovic ◽  
Ljudmila Nagorni-Obradovic ◽  
Mihailo Stjepanovic ◽  
Darija Kisic-Tepavcevic ◽  
...  
Keyword(s):  
Palliative Care ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
End Stage ◽  
Nsclc Patients

ABSTRACTObjective:Under conditions in which palliative care has not yet become part of clinical practice, the differences in palliative care needs between patients with cancer and other life-limiting diseases can yield knowledge that will be very valuable for future planning. The aim of our investigation was to compare health-related quality of life (HRQoL) for patients with end-stage chronic obstructive pulmonary disease (COPD) and those with non-small-cell lung cancer (NSCLC) in Belgrade, Serbia. We also evaluated the influence of demographic, socioeconomic, and clinical factors on HRQoL for both patient groups.Method:This cross-sectional study included 100 NSCLC patients (stages IIIb and IV) and 100 patients with stage IV COPD. Measures included the SF-36 questionnaire, the EORTC QLQ–C30, the St. George's Respiratory Questionnaire, and the Beck Depression Inventory (BDI). Associations of demographic, socioeconomic, and clinical factors with QoL were examined using linear regression analyses.Results:The COPD group scored significantly lower compared to NSCLC patients in all SF-36 domains except for bodily pain. Additionally, a significantly higher level of depressive symptoms was observed in COPD patients. A worse physical QoL for COPD patients was independently associated with a longer duration of unemployment, a lack of wage earning, lower Karnofsky Performance Status (KPS) scores, and higher levels of depression. A worse mental QoL for COPD patients was related to a longer duration of disease, poorer KPS scores, and higher BDI scores. The independent variables significantly associated with worse physical and mental QoL of NSCLC patients were lower KPS and higher BDI scores.Significance of Results:A worse QoL, a significantly higher level of depressive symptoms, and adverse socioeconomic status in the COPD group imposes the need for development of more intensive psychosocial and community support for COPD patients during implementation of palliative care.

scholarly journals “Changes in health-related quality of life as a marker in the prognosis in COPD patients”

2021 ◽  
pp. 00181-2021
Author(s):  
Cristóbal Esteban ◽  
Inmaculada Arostegui ◽  
Amaia Aramburu ◽  
Javier Moraza ◽  
Myriam Aburto ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive ◽  
Health Related Quality ◽  
Obstructive Pulmonary Disease ◽  
General Terms ◽  
Copd Patients ◽  
Point Increase ◽  
Related Quality ◽  
Health Related

Chronic obstructive pulmonary disease (COPD) is understood as a complex, heterogeneous and multisystem airway obstructive disease. The association of deterioration in health-related quality of life (HRQoL) with mortality and hospitalisation for COPD exacerbation has been explored in general terms. The specific objectives of this study were to determine whether a change in HRQoL is related over time with mortality and hospitalisation. Overall, 543 patients were recruited through Galdakao Hospital's five outpatient respiratory clinics. Patients were assessed at baseline and the end of the first and second year and were followed-up for 3 years. At each assessment, measurements were made of several variables, including HRQoL using the Saint George's Respiratory Questionnaire (SGRQ). The cohort had moderate obstruction (FEV1 55% of the predicted value). SGRQ total, symptoms, activity and impact scores at baseline were 39.2, 44.5, 48.7 and 32.0, respectively. Every 4-point increase in the SGRQ was associated with an increase in the likelihood of death: “symptoms” domain odds ratio (OR)=1.04; 95% CI (1.00–1.08); “activity” domain OR=1.12; 95% CI (1.08–1.17) and “impacts” domain OR=1.11; 95% CI (1.06–1.15). The rate of hospitalisations per year was 5% (95% CI 3%-8%) to 7% (95% CI 5%-10%) higher for each 4-point increase in the separate domains of the SGRQ. Deterioration in HRQoL by 4 points in SGRQ domain scores over 1 year was associated with an increased likelihood of death and hospitalisation.

scholarly journals Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Boyuk Moradkhani ◽  
Samaneh Mollazadeh ◽  
Parastoo Niloofar ◽  
Afsaneh Bashiri ◽  
Mohammad Bagher Oghazian
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Medication Adherence ◽  
Chronic Obstructive ◽  
Health Related Quality ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Related Quality ◽  
Health Related

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is one of the prominent cause of mortality worldwide. Nowadays, the level of medication adherence in COPD patients is very low, which reduces the clinical therapeutic effects. The purpose of the present study is to investigate the relationship between medication adherence and Health-Related Quality of Life (HRQoL) in COPD patients referred to the pulmonologist’s office. Methods This observational study was performed on 100 COPD outpatient cases. Each patient was interviewed to answer questionnaires regarding demographic and clinical information. To assess quality of life, health status, and severity of dyspnea, the St George’s Respiratory Questionnaire - COPD-Specific Version (SGRQ-C), COPD Assessment Test (CAT), and Modified British Medical Research Council (mMRC) questionnaires were used, respectively. Persian version of the Morisky Medication Adherence Scale (MMAS-8-Item) was used to measure medication adherence. To determine the adherence predictors, an ordinal logistic regression analysis was performed. Results Out of 100 patients with mean (±SD) age of 61.35 (±10.79) years, 74% had medium and high medication adherence. In the final ordinal logistic model, quality of life, health status, and education level found to have positive effect on medication adherence while polypharmacy had negative effect. We did not find any significant association between age, gender, Body Mass Index (BMI), and other variables with medication adherence. Conclusions Patients with high quality of life are more adherent to their medications. Furthermore, patients who have polypharmacy, tend to have less adherence to their medications.

The different phenotypes of COPD

2021 ◽  
Author(s):  
Ahmed Yousuf ◽  
Hamish McAuley ◽  
Omer Elneima ◽  
Christopher E Brightling
Keyword(s):  
Biologic Therapy ◽  
Stable State ◽  
Symptom Burden ◽  
Chronic Obstructive ◽  
Blood Eosinophil ◽  
Eosinophilic Inflammation ◽  
Significant Morbidity ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Eosinophil Counts

Abstract Background Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity and mortality. To improve the health status and reduce symptom burden, it is important to identify a group of patients with similar characteristics and prognosis, called clinical phenotypes. Herein we shall review the different phenotypes of COPD. Sources of data Keywords (COPD, phenotype, acute exacerbation) search was conducted in PubMed, Google Scholar. Areas of agreement Those with raised blood eosinophil counts respond better to steroid therapy at stable state and exacerbation. Areas of controversy There is no universally accepted blood eosinophil cut-off value that will indicate favourable response to corticosteroids and potentially for future biologic therapy. Growing points There is an urgent need for further therapeutic options for COPD patients with non-eosinophilic inflammation. Areas timely for developing research Well-designed COPD trials with identification of phenotypes for more personalization of the treatment of COPD.

scholarly journals Model for Developing a Health-Related Quality of Life Questionnaire for Chronic Obstructive Pulmonary Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Nikolić Emilija ◽  
Nikolić Aleksandar ◽  
Stević Ruža ◽  
Brandmajer Tijana ◽  
Mićanović Veselin ◽  
...  
Keyword(s):  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Exacerbation Frequency ◽  
Hrqol Questionnaire ◽  
Copd Patients ◽  
Related Quality ◽  
Health Related ◽  
Male Patients ◽  
The Mathematical Model

Introduction. The St. George’s Respiratory Questionnaire (SGRQ), Modified Medical Research Council (mMRC) Dyspnea Scale, Hospital Anxiety and Depression Scale (HADS), and general health questionnaire (SF-36) are widely used for chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD). Aim. We examined the reliability and validity of a modified questionnaire (MQ) to create a model for assessing the health-related quality of life (HRQOL) in COPD. Method. In total, 132 COPD patients completed the MQ. Lung function, smoking index, and exacerbation frequency were measured. Cronbach’s α coefficient of correlation, standard deviation, and multifactorial nonlinear regression analysis were used to verify the internal validity of the MQ and to develop the mathematical model. Results. Female (63) patients had lesser airway obstruction than, and exacerbation frequency similar to that of, male patients. Exacerbation frequency significantly correlated with spirometry parameters in female patients. The MQ total score achieved high internal consistency (Cronbach’s α = 0.89) and showed significant correlations with exacerbation frequency, smoking habit, and spirometry parameters in male patients (p<0.005). Conclusion. The HRQOL questionnaire was shown to be a good indicator of the health status of COPD patients. The mathematical model easily and precisely confirmed the score of HRQOL questionnaire.

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