Core/Shell Gel Beads with Embedded Halloysite Nanotubes for Controlled Drug Release

The use of nanocomposites based on biopolymers and nanoparticles for controlled drug release is an attractive notion. We used halloysite nanotubes that were promising candidates for the loading and release of active molecules due to their hollow cavity. Gel beads based on chitosan with uniformly dispersed halloysite nanotubes were obtained by a dropping method. Alginate was used to generate a coating layer over the hybrid gel beads. This proposed procedure succeeded in controlling the morphology at the mesoscale and it had a relevant effect on the release profile of the model drug from the nanotube cavity.

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Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core–Shell Hybrid Microspheres

ACS Nano ◽

10.1021/nn300303q ◽

2012 ◽

Vol 6 (4) ◽

pp. 3327-3338 ◽

Cited By ~ 253

Author(s):

Yunlu Dai ◽

Ping’an Ma ◽

Ziyong Cheng ◽

Xiaojiao Kang ◽

Xiao Zhang ◽

...

Keyword(s):

Drug Release ◽

Cell Imaging ◽

Controlled Drug Release ◽

Core Shell

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Fabrication and characterization of monodisperse PLGA–alginate core–shell microspheres with monodisperse size and homogeneous shells for controlled drug release

Acta Biomaterialia ◽

10.1016/j.actbio.2013.03.022 ◽

2013 ◽

Vol 9 (7) ◽

pp. 7410-7419 ◽

Cited By ~ 105

Author(s):

Jun Wu ◽

Tiantian Kong ◽

Kelvin Wai Kwok Yeung ◽

Ho Cheung Shum ◽

Kenneth Man Chee Cheung ◽

...

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Core Shell ◽

Fabrication And Characterization

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ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release

RSC Advances ◽

10.1039/d1ra03899k ◽

2021 ◽

Vol 11 (48) ◽

pp. 29986-29996

Author(s):

Xiuxiu Qi ◽

Hongmei Yan ◽

Yingxue Li

Keyword(s):

Controlled Release ◽

Drug Release ◽

Self Assembly ◽

Drug Loading ◽

Controlled Drug Release ◽

Ph Sensitive ◽

Core Shell ◽

Assembly Process ◽

Block Polymer ◽

Hollow Mesoporous Silica

A pH-sensitive core–shell nanoparticle (HMS@C18@PSDMA-b-POEGMA) was developed via a self-assembly process as the carrier of anticancer drug doxorubicin (DOX) for drug loading and controlled release.

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Pegylated CdSe/ZnS core/shell nanoparticles for controlled drug release

Materials Science and Engineering B ◽

10.1016/j.mseb.2019.03.015 ◽

2019 ◽

Vol 243 ◽

pp. 115-124 ◽

Cited By ~ 2

Author(s):

Shivani Bharti ◽

Gurvir Kaur ◽

Shikha Gupta ◽

S.K. Tripathi

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Core Shell ◽

Shell Nanoparticles ◽

Core Shell Nanoparticles

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Multi-walled carbon nanotube-incorporating electrospun composite fibrous mats for controlled drug release profile

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2019.118513 ◽

2019 ◽

Vol 568 ◽

pp. 118513 ◽

Cited By ~ 10

Author(s):

Y. Emre Bulbul ◽

Ş. Melda Eskitoros-Togay ◽

Funda Demirtas-Korkmaz ◽

Nursel Dilsiz

Keyword(s):

Carbon Nanotube ◽

Drug Release ◽

Controlled Drug Release ◽

Release Profile ◽

Drug Release Profile ◽

Multi Walled Carbon Nanotube

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Dual responsive polymeric bionanocomposite gel beads for controlled drug release systems

Journal of Applied Polymer Science ◽

10.1002/app.45143 ◽

2017 ◽

Vol 134 (33) ◽

pp. 45143 ◽

Cited By ~ 1

Author(s):

Dariush Nikjoo ◽

Ayse Z. Aroguz

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Dual Responsive ◽

Gel Beads

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Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation

Journal of Chemistry ◽

10.1155/2017/6924601 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12

Author(s):

Abdul Karim ◽

Muhammad Ashraf Shaheen ◽

Tahir Mehmood ◽

Abdul Rauf Raza ◽

Musadiq Aziz ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Lag Time ◽

Zero Order ◽

Release Profile ◽

Drug Release Profile ◽

Independent Variables ◽

Zero Order Kinetics ◽

Model Drug ◽

Predicted Values

The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 32factorial designs. The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG) and citric acid (CA) with an increment in floating time. The stearic acid (SA) has been used to decrease the lag time because a decrease in density of system was observed. The kinetic analysis showed that the optimized formulation (S4F3) followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability. The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT.

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