The Role of Surface in the Pathogenesis and Treatment of COVID-19
Keyword(s):
Recently, an inverse relationship between incidence of COVID-19 and seasonal aerosolization of mold spores was demonstrated. Analyses of that relationship suggested mold spores compete with SARS-CoV-2 virions for a receptor on the pulmonary epithelial surface. By inference, the operative receptor was proposed to be Toll-like receptor 4, with surface-localized virions being responsible for symptomatology. In this report, the pathogenesis of COVID-19 is further developed, with a focus on a role for surfactant protein D in the process. This developed proposal provides both mechanistic understanding and suggested treatments of COVID-19.
2015 ◽
Vol 29
(2)
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pp. 433-439
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2015 ◽
Vol 32
(1)
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pp. 59-63
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2005 ◽
Vol 35
(12)
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pp. 1615-1624
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