Myocardial Glucose Metabolism Is Increased in Newly Diagnosed Lung Adenocarcinoma

<b><i>Background:</i></b> Cardiac metabolism alterations may be involved in abnormalities of cancer patients’ cardiovascular system. This study aimed to explore whether left ventricular myocardial glucose metabolism is altered and its related factors in newly diagnosed patients with lung adenocarcinoma (LAD) who underwent fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT). <b><i>Methods:</i></b> From our ¹⁸F-FDG PET/CT imaging database, 171 patients with newly diagnosed LAD and 43 nononcologic subjects with matched age and sex were retrospectively analyzed. The included patients underwent conventional ¹⁸F-FDG PET/CT imaging with a &#x3e;12-h fasting before ¹⁸F-FDG administration. The standardized uptake values (SUVs) of the left ventricular (LV) myocardium, arterial wall, epicardial adipose tissue (EAT), spleen, and bone marrow were separately measured. Laboratory parameters and echocardiographic results were collected as well. LAD patients were divided into 2 groups based on the 95th percentile of LV maximal SUV (SUV_max) obtained from the 43 nononcologic subjects. Univariate analysis and multiple logistic regression analysis were used to identify significant factors. <b><i>Results:</i></b> Higher LV SUV_max was found (3.8 [2.4, 7.7] vs. 3.0 [2.0, 5.4], <i>p</i> = 0.052) in LAD than that in nononcologic patients, whereas no significant differences of ¹⁸F-FDG uptake were found in the arterial wall, EAT, spleen, or bone marrow between LAD patients and controls. The maximum diameter (<i>D</i>_max) of the LAD lesion, SUV_max of spleen, and SUV_max of EAT were related to LV SUV_max in LAD. <b><i>Conclusions:</i></b> Myocardial glucose metabolism is increased in patients with newly diagnosed LAD. <i>D</i>_max of LAD lesion, spleen activity, and EAT activity contribute to the increased LV activity in LAD.

Application of Carbon-13 Isotopomer Analysis to Assess Perinatal Myocardial Glucose Metabolism in Sheep

Ovine models of pregnancy have been used extensively to study maternal–fetal interactions and have provided considerable insight into nutrient transfer to the fetus. Ovine models have also been utilized to study congenital heart diseases. In this work, we demonstrate a comprehensive assessment of heart function and metabolism using a perinatal model of heart function with the addition of a [U-13C]glucose as tracer to study central energy metabolism. Using nuclear magnetic resonance spectroscopy, and metabolic modelling, we estimate myocardial citric acid cycle turnover (normalized for oxygen consumption), substrate selection, and anaplerotic fluxes. This methodology can be applied to studying acute and chronic effects of hormonal signaling in future studies.