Role of genetic variants of Vitamin D receptor, Toll-like receptor 2 and Toll-like receptor 4 in extrapulmonary tuberculosis

2021 ◽  
pp. 104911
Author(s):  
Bilal Ahmad Wani ◽  
Faheem Shehjar ◽  
Sonaullah Shah ◽  
Ajaz Koul ◽  
Adfar Yusuf ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Genetic Variants ◽  
Extrapulmonary Tuberculosis ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Toll Like Receptor 2

scholarly journals Polymorphisms in IL-1β, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Alison A Motsinger-Reif ◽  
Paulo RZ Antas ◽  
Noffisat O Oki ◽  
Shawn Levy ◽  
Steven M Holland ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Extrapulmonary Tuberculosis ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Polymorphisms in vitamin D receptor, toll-like receptor 2 and Toll-Like receptor 4 genes links with Dengue susceptibility

2021 ◽  
Vol 17 (4) ◽  
pp. 506-513
Author(s):  
Arvind Kumar Singh ◽  
Keyword(s):  
Vitamin D ◽  
Virus Infection ◽  
Dengue Virus ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
P Value ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Dengue Virus Infection ◽  
Toll Like Receptor 2

Host genetic factors are known to determine disease susceptibility in dengue virus infection. Therefore, in this study association of gene polymorphisms of Vitamin D Receptor [rs731236 (Taq) and rs7975232(Apa1)], Toll-like receptor 2 [rs5743708(Arg735Gln) and rs5743704(Pro631His)] and Toll-like receptor 4 [rs4986790A/G(Asp299Gly13843) and rs4986791 C/T(Thr399Ile)] were studied in cases with dengue as compared to controls. Total 98 cases of confirmed dengue virus infection and 98 age, sex and geographically matched healthy controls were enrolled and their genetic polymorphisms for the above mentioned regions were studied by Sanger sequencing. Mutant genotypes CC of VDR rs731236(Taq1) [(OR 3.808, p value =0.02, CI 1.160-12.498)], GG of VDR rs7975232 (Apa1) [(OR 3.485, p value =0.02, CI 1.162-10.45)] and heterozygous genotypes of TLR4 rs4986790 A/G Asp299Gly [OR 2.40, p value= 0.02, CI 1.12-5.14], TLR4 rs4986791 C/T Thr399Ile [OR 2.09, p value=0.02, CI 1.12-5.14] were found to be significantly more in cases with dengue virus infection as compared to the controls. Also, at these positions mutant alleles were observed in significantly higher number of cases than controls. The values for C allele at VDR rs731236(Taq1) were OR 1.86, p value 0.009, CI 1.162-3.001; for allele G at rs7975232(Apa1) were OR 2.71, p value 0.006, CI 1.196-2.98 for allele G at TLR4s rs4986790 A/G Asp299Gly were OR 2.35, p value 0.009, CI 1.23-4.50 and for allele T at rs4986791 C/T Thr399Ile were OR 2.36, p value=0.006, CI 1.28-4.38. VDR and TLR4 but not TLR2 gene polymorphisms were found to be associated with dengue susceptibility in Indian population.

scholarly journals 25-Hydroxy Vitamin D, Vitamin D Receptor and Toll-like Receptor 2 Polymorphisms in Spinal Tuberculosis

Medicine ◽  
2016 ◽  
Vol 95 (17) ◽  
pp. e3418 ◽  
Author(s):  
Ajay Panwar ◽  
Ravindra Kumar Garg ◽  
Hardeep Singh Malhotra ◽  
Amita Jain ◽  
Arvind Kumar Singh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Spinal Tuberculosis ◽  
Toll Like Receptor ◽  
25 Hydroxy Vitamin D ◽  
Toll Like Receptor 2

Association of vitamin D receptor and toll like receptor genetic variants and haplotypes with colon cancer risk: A case control study in Egypt

Meta Gene ◽  
2017 ◽  
Vol 11 ◽  
pp. 209-216
Author(s):  
Ragaa A. Ramadan ◽  
Lubna M. Desouky ◽  
Mai Moaaz ◽  
Mostafa A. Elnaggar ◽  
Mohamed Selima ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Toll Like Receptor ◽  
Colon Cancer Risk ◽  
Control Study

Vitamin D status, vitamin D receptor and toll like receptor-2 polymorphisms in tuberculous meningitis: a case–control study

Infection ◽  
2016 ◽  
Vol 44 (5) ◽  
pp. 633-640 ◽  
Author(s):  
Imran Rizvi ◽  
Ravindra Kumar Garg ◽  
Amita Jain ◽  
Hardeep Singh Malhotra ◽  
Arvind Kumar Singh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Tuberculous Meningitis ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin D Status ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2 ◽  
Control Study
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