scholarly journals Comparative Proteomic Study Shows the Expression of Hint-1 in Pituitary Adenomas

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 330
Author(s):  
Carolina Carrillo-Najar ◽  
Daniel Rembao-Bojórquez ◽  
Martha L. Tena-Suck ◽  
Sergio Zavala-Vega ◽  
Noemí Gelista-Herrera ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Biological Behavior ◽  
Ki 67 ◽  
Non Invasive ◽  
Proteomic Study ◽  
Neoplastic Process ◽  
Adenohypophyseal Hormones ◽  
Aggressive Tumors ◽  
Proteomic Map

Pituitary adenomas (PAs) can be unpredictable and aggressive tumors. No reliable markers of their biological behavior have been found. Here, a proteomic analysis was applied to identify proteins in the expression profile between invasive and non-invasive PAs to search for possible biomarkers. A histopathological and immunohistochemical (adenohypophyseal hormones, Ki-67, p53, CD34, VEGF, Flk1 antibodies) analysis was done; a proteomic map was evaluated in 64 out of 128 tumors. There were 107 (84%) invasive and 21 (16%) non-invasive PAs; 80.5% belonged to III and IV grades of the Hardy–Vezina classification. Invasive PAs (n = 56) showed 105 ± 43 spots; 86 ± 32 spots in non-invasive PAs (n = 8) were observed. The 13 most prominent spots were selected and 11 proteins related to neoplastic process in different types of tumors were identified. Hint1 (Histidine triad nucleotide-binding protein 1) high expression in invasive PA was found (11.8 ± 1.4, p = 0.005), especially at high index (>10; p = 0.0002). High Hint1 expression was found in invasive VEGF positive PA (13.8 ± 2.3, p = 0.005) and in Flk1 positive PA (14.04 ± 2.28, p = 0.006). Hint1 is related to human tumorigenesis by its interaction with signaling pathways and transcription factors. It could be related to invasive behavior in PAs. This is the first report on Hint expression in PAs. More analysis is needed to find out the possible role of Hint in these tumors.

scholarly journals Salivary Gland-Like Tumor of the Sella

2007 ◽  
Vol 34 (4) ◽  
pp. 478-482 ◽  
Author(s):  
Wouter van Furth ◽  
Harley S. Smyth ◽  
Eva Horvath ◽  
Kalman Kovacs ◽  
Fateme Salehi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Pituitary Adenomas ◽  
Biological Behavior ◽  
Benign Tumors ◽  
Sellar Region ◽  
Non Invasive ◽  
Medical Issues ◽  
Sellar Tumor ◽  
Pituitary Carcinomas

Tumors arising in the sellar region are predominantly benign, non-invasive pituitary adenomas. Invasive pituitary adenomas (approximately 35 % of the pituitary adenomas) and pituitary carcinomas (0.1 – 0.5 %) arise from the same cells in the pituitary gland as the benign tumors, but have different pathology and biological behavior. A wide variety of nonadenomatous lesions involve the sellar region. These include tumors that arise specifically from sellar and suprasellar structures, as well as those that are also found elsewhere in the CNS (e.g. meningioma, glioma, metastasis, etc.). Typical nonadenomatous tumors that originate in the sellar region are craniopharyngioma and Rathke’s cleft cyst. The purpose of this paper is to describe another nonadenomatous tumor specific to the sellar region, a salivary gland-like tumor, and review the literature on this subject. This case report will also illustrate the management decisions regarding a patient with multiple medical issues and an aggressive sellar tumor.

Role of Ki-67 proliferation index and p53 expression in predicting progression of pituitary adenomas

2008 ◽  
Vol 39 (5) ◽  
pp. 758-766 ◽  
Author(s):  
Roger Gejman ◽  
Brooke Swearingen ◽  
E. Tessa Hedley-Whyte
Keyword(s):  
Pituitary Adenomas ◽  
Proliferation Index ◽  
Ki 67 ◽  
P53 Expression

Radically resected pituitary adenomas: prognostic role of Ki 67 labeling index in a monocentric retrospective series and literature review

Pituitary ◽  
2013 ◽  
Author(s):  
Sabrina Chiloiro ◽  
Antonio Bianchi ◽  
Francesco Doglietto ◽  
Chiara de Waure ◽  
Antonella Giampietro ◽  
...  
Keyword(s):  
Literature Review ◽  
Pituitary Adenomas ◽  
Labeling Index ◽  
Prognostic Role ◽  
Ki 67

scholarly journals Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications

2009 ◽  
Vol 16 (3) ◽  
pp. 1029-1043 ◽  
Author(s):  
Marie-Lise Jaffrain-Rea ◽  
Mariolina Angelini ◽  
Donatella Gargano ◽  
Maria A Tichomirowa ◽  
Adrian F Daly ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Pituitary Adenomas ◽  
Pituitary Tumour ◽  
Clinical Implications ◽  
Rt Pcr ◽  
Interacting Protein ◽  
Non Invasive ◽  
Aryl Hydrocarbon ◽  
Sensitive Tool

Germline mutations of the aryl hydrocarbon receptor (AHR)-interacting protein (AIP) gene confer a predisposition to pituitary adenomas (PA), usually in the setting of familial isolated PA. To provide further insights into the possible role of AIP in pituitary tumour pathogenesis, the expression of AIP and AHR was determined by real-time RT-PCR and/or immunohistochemistry (IHC) in a large series of PA (n=103), including 17 with AIP mutations (AIPmut). Variable levels of AIP and AHR transcripts were detected in all PA, with a low AHR expression (P<0.0001 versus AIP). Cytoplasmic AIP and AHR were detected by IHC in 84.0 and 38.6% of PA respectively, and significantly correlated with each other (P=0.006). Nuclear AHR was detected in a minority of PA (19.7%). The highest AIP expression was observed in somatotrophinomas and non-secreting (NS) PA, and multivariate analysis in somatotrophinomas showed a significantly lower AIP immunostaining in invasive versus non-invasive cases (P=0.019). AIP expression was commonly low in other secreting PA. AIP immunostaining was abolished in a minority of AIPmut PA, with a frequent loss of cytoplasmic AHR and no evidence of nuclear AHR. In contrast, AIP overexpression in a subset of NS PA could be accompanied by nuclear AHR immunopositivity. We conclude that down-regulation of AIP and AHR may be involved in the aggressiveness of somatotrophinomas. Overall, IHC is a poorly sensitive tool for the screening of AIP mutations. Data obtained on AHR expression suggest that AHR signalling may be differentially affected according to PA phenotype.

scholarly journals Meningiomas in Premenopausal Women: Role of the Hormone Related Conditions

2020 ◽  
Vol 10 ◽  
Author(s):  
Francesco Maiuri ◽  
Giuseppe Mariniello ◽  
Teresa Somma ◽  
Elia Guadagno ◽  
Sergio Corvino ◽  
...  
Keyword(s):  
Oral Contraceptives ◽  
Premenopausal Women ◽  
Tumor Location ◽  
Biological Behavior ◽  
Pathological Findings ◽  
Ki 67 ◽  
Who Grade ◽  
Female Sex Hormones ◽  
Significant Difference

BackgroundSeveral epidemiological and pathological findings suggest that the female sex hormones may influence the development of meningiomas. However, the role of pregnancy, oral contraceptives, and fertilization therapies is still controversial.MethodsFrom the surgical series of 354 patients with meningiomas operated between 2006 and 2019, the group of 72 premenopausal women was separately considered. The tumor location, WHO grade, Ki67-labeling index (LI), progesterone receptor (PR) expression, and histological types were studied in premenopausal women with and without hormone-related conditions were compared.ResultsIn this premenopausal group, 24 patients had hormone-related conditions, including use of oral contraceptives in 16, intrauterine fertilization in one, pregnancy in three, and tumors of the female reproductive system in four. The group of patients with hormone-related conditions, as compared to that with no hormone related conditions, showed slightly lower median age (38 versus 43 years) and no significant difference of meningioma location WHO grade, Ki 67-Li, PR expression and histological type. The clinical onset during pregnancy in three patients and tumor growth during contraceptive progesterone therapy in two others were evidenced.ConclusionThe biological behavior of meningiomas and their pathological findings, including PR expression, are not correlated with the different hormone related conditions in premenopausal female patients. Contraceptives and fertilization therapies, mainly with progesterone, should be avoided in patients with meningiomas.

Atypical pituitary adenomas: clinical characteristics and role of ki-67 and p53 in prognostic and therapeutic evaluation. A series of 50 patients

2016 ◽  
Vol 40 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Marialaura Del Basso De Caro ◽  
Domenico Solari ◽  
Francesca Pagliuca ◽  
Alessandro Villa ◽  
Elia Guadagno ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Clinical Characteristics ◽  
Ki 67 ◽  
Therapeutic Evaluation

scholarly journals Chemotherapy and role of the proliferation marker Ki-67 in digestive neuroendocrine tumors

2007 ◽  
Vol 14 (2) ◽  
pp. 221-232 ◽  
Author(s):  
Eduardo Vilar ◽  
Ramón Salazar ◽  
Jose Pérez-García ◽  
Javier Cortes ◽  
Kjell Öberg ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Retrospective Studies ◽  
Response To Treatment ◽  
Biological Behavior ◽  
Endocrine Tumors ◽  
Ki 67 ◽  
Pancreatic Endocrine Tumors ◽  
Poorly Differentiated ◽  
Selection For

Neuroendocrine tumors (NETs) of the digestive tract are a heterogeneous group of rare malignancies. Three major subgroups can be defined: pancreatic endocrine tumors, carcinoid tumors, and poorly differentiated gastroenteropancreatic NETs. Classically, digestive NETS have been considered to have an indolent course characterized for prolonged stabilizations or slow progressions, but there are clear differences in terms of aggressiveness, clinical course, and response to treatment among them. Retrospective studies have identified several clinicopathological and immunohistochemical factors as angioinvasion and proliferative index assessed by Ki-67 expression, which predict biological behavior and correlate with survival. Chemotherapy regimens based on the combination of several active drugs such as streptozocin, doxorubicin, 5-fluorouracil, dacarbazine, and temozolomide show low response rates, which sets the need to improve the results of the medical treatment of these malignancies. This review will analyze the role of Ki-67 in digestive NETs under a clinical perspective and will suggest future fields for development of this approach that enable a better patient selection for chemotherapy. Also a comprehensive review of the literature about chemotherapy in NETs is presented.

The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix

2011 ◽  
Vol 202 (4) ◽  
pp. 400-403 ◽  
Author(s):  
Eric Liu ◽  
Dana A. Telem ◽  
Richard R.P. Warner ◽  
Andrew Dikman ◽  
Celia M. Divino
Keyword(s):  
Carcinoid Tumor ◽  
Goblet Cell ◽  
Biological Behavior ◽  
Goblet Cell Carcinoid ◽  
Ki 67
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