scholarly journals The Wide Morphological Spectrum of Deep (Aggressive) Angiomyxoma of the Vulvo-Vaginal Region: A Clinicopathologic Study of 36 Cases, Including Recurrent Tumors

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1360
Author(s):  
Gaetano Magro ◽  
Giuseppe Angelico ◽  
Michal Michal ◽  
Giuseppe Broggi ◽  
Gian Franco Zannoni ◽  
...  
Keyword(s):  
Female Genital Tract ◽  
High Rate ◽  
Aggressive Angiomyxoma ◽  
Neoplastic Cells ◽  
Primary Tumors ◽  
Clinicopathologic Study ◽  
Recurrent Tumors ◽  
Typical Morphology ◽  
Locally Recurrent ◽  
Female Genital

Background: Deep angiomyxoma (DAM) is currently included in the category of “specific stromal tumors of the lower female genital tract”, along with angiomyofibroblastoma, cellular angiofibroma and myofibroblastoma. Given the high rate of local recurrences, it is crucial to recognize DAM from other tumors that possess indolent behaviour. In the present paper, we analyzed the morphological and immunohistochemical features of 42 surgically-resected vulvo-vaginal DAMs (36 primary and 6 recurrent lesions) in order to widen the morphological spectrum of this uncommon tumor. Methods: A series of 36 cases of surgically-resected primary vulvo-vaginal DAMs were retrospectively collected. Locally recurrent tumors were also available for six of these cases. Results: Out of the primary tumors, 25 out of 36 exhibited the classic-type morphology of DAM. In the remaining cases (11/36 cases), the following uncommon features, which sometimes coexist with one another, were observed: (i) alternating myxoid and collagenized/fibrous areas; (ii) hypercellular areas; (iii) neurofibroma-like appearance; (iv) perivascular hyalinization; (v) microcystic/reticular stromal changes; (vi) “microvascular growth pattern”; (vii) perivascular cuffing; (viii) nodular leiomyomatous differentiation; (ix) hypocellular and fibro-sclerotic stroma. Among the six locally recurrent tumors the following features were observed: (i) classic-type morphology; (ii) hypocellular fibro-sclerotic stroma; (iii) extensive perivascular hyalinization, lumen obliteration and formation of confluent nodular sclerotic masses; (iv) hypercellularity. Immunohistochemically, the neoplastic cells of classic-type DAM in both primary and recurrent tumors were diffusely stained with desmin, suggesting a myofibroblastic nature; in contrast, the neoplastic cells showing elongated fibroblastic-like morphology and set in collagenized/fibrosclerotic stroma in both primary and recurrent tumors were negative or only focally stained with desmin, which is consistent with a fibroblastic profile. Conclusion: Although diagnosis of DAM is usually straightforward if typical morphology is encountered, diagnostic problems may arise when a pathologist is dealing with unusual morphological features, especially hypercellularity, extensive collagenous/fibrosclerotic stroma or neurofibroma-like appearance.

scholarly journals Vaginal Angiomyofibroblastoma: A Case Report and Review of Diagnostic Imaging

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Sarah Eckhardt ◽  
Renee Rolston ◽  
Suzanne Palmer ◽  
Begum Ozel
Keyword(s):  
Transvaginal Ultrasound ◽  
Female Genital Tract ◽  
Premenopausal Women ◽  
Preoperative Assessment ◽  
Transvaginal Sonography ◽  
Aggressive Angiomyxoma ◽  
Resonance Imaging ◽  
Pathologic Findings ◽  
Locally Recurrent ◽  
Female Genital

Background. Angiomyofibroblastoma (AMFB) is a benign mesenchymal tumor most commonly found in the female genital tract of premenopausal women. Although rare, AMFB is an important consideration in the differential diagnosis of vulvar and vaginal masses, as it must be distinguished from aggressive angiomyxoma (AA), a locally recurrent, invasive, and damaging tumor with similar clinical and pathologic findings. Case. We describe a patient with a 4 cm vaginal AMFB and the relevant preoperative radiographic imaging findings. Conclusion. Preoperative diagnosis of AMFB remains difficult. Common findings on magnetic resonance imaging and transvaginal sonography are described. We conclude that both transvaginal ultrasound and MRI are potentially useful imaging modalities in the preoperative assessment of vulvar and vaginal AMFB, with more data needed to determine superiority of one modality over the other.

Aggressive Angiomyxoma of the Female Genital Tract

2005 ◽  
Vol 10 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Bonnie L. Balzer ◽  
Teri A. Longacre
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Aggressive Angiomyxoma ◽  
Female Genital

scholarly journals Synchronous primary tumors of the endometrium and ovary

1970 ◽  
Vol 2 (3) ◽  
pp. 189-192 ◽  
Author(s):  
S Karki ◽  
U Chapagain
Keyword(s):  
Genital Tract ◽  
Endometrial Hyperplasia ◽  
Female Genital Tract ◽  
Premenopausal Women ◽  
Ovarian Tumors ◽  
University Teaching ◽  
Primary Tumors ◽  
Atypical Endometrial Hyperplasia ◽  
Ovarian Cancers ◽  
Female Genital

Background: Primary synchronous cancer of the female genital tract is a relatively uncommon. Simultaneously detected endometrial and ovarian malignancies constitute the commonest occurrence. A set of pathological criteria has been described to differentiate synchronous primaries from metastatic tumors. The purpose of this study was to characterize patients with synchronous primary endometrial and ovarian tumors. Materials and Methods: This was a retrospective study done in Department of Pathology, Tribhuwan University Teaching Hospital from September 2006 to August 2011. The datas were retrieved from computer database. Results: There were totally of 10 cases of simultaneously detected endometrial and ovarian cancers. Out of 10 cases, 7 cases were synchronous primary endometrial and ovarian cancers while three were metastatic. Median age at presentation was 47.4 years. Six (85.8%) of these patients presenting with dual primary tumors were premenopausal. Grade 1 histology was seen in 57% of endometrial and 42% of ovarian tumors. Atypical endometrial hyperplasia was found in 42.8% of cases while none of the cases showed endometriosis. Conclusion: Though limited by relatively small number of cases, younger and premenopausal women were predisposed to developing synchronous primary tumors of the endometrium and ovary. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6019 JPN 2012; 2(3): 189-192

Individualized managing strategies of aggressive angiomyxoma of female genital tract and pelvis

2013 ◽  
Vol 39 (10) ◽  
pp. 1101-1108 ◽  
Author(s):  
H.M. Bai ◽  
J.X. Yang ◽  
H.F. Huang ◽  
D.Y. Cao ◽  
J. Chen ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Aggressive Angiomyxoma ◽  
Female Genital

Granulocytic Sarcoma of the Female Genital Tract: A Clinicopathologic Study of 11 Cases

1997 ◽  
Vol 21 (10) ◽  
pp. 1156-1165 ◽  
Author(s):  
Esther Oliva ◽  
Judith A. Ferry ◽  
Robert H. Young ◽  
Jaime Prat ◽  
John R. Srigley ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Granulocytic Sarcoma ◽  
Clinicopathologic Study ◽  
Female Genital

Peripheral T/Natural killer-cell lymphoma involving the female genital tract: A clinicopathologic study of 5 cases

2001 ◽  
Vol 73 (1) ◽  
pp. 108-114 ◽  
Author(s):  
Shigeo Nakamura ◽  
Miyuki Kato ◽  
Koichi Ichimura ◽  
Yasushi Yatabe ◽  
Yoshitoyo Kagami ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Genital Tract ◽  
Cell Lymphoma ◽  
Killer Cell ◽  
Female Genital Tract ◽  
Natural Killer Cell Lymphoma ◽  
Clinicopathologic Study ◽  
Female Genital

scholarly journals Potential for Mitochondrial DNA Sequencing in the Differential Diagnosis of Gynaecological Malignancies

2018 ◽  
Vol 19 (7) ◽  
pp. 2048 ◽  
Author(s):  
Anna Perrone ◽  
Giulia Girolimetti ◽  
Martina Procaccini ◽  
Lorena Marchio ◽  
Alessandra Livi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Histopathological Examination ◽  
Female Genital Tract ◽  
Primary Tumors ◽  
Ovarian Metastases ◽  
Molecular Analyses ◽  
Metastatic Lesions ◽  
Lesion Type ◽  
Novel Method ◽  
Female Genital

In the event of multiple synchronous gynecological lesions, a fundamental piece of information to determine patient management, prognosis, and therapeutic regimen choice is whether the simultaneous malignancies arise independently or as a result of metastatic dissemination. An example of synchronous primary tumors of the female genital tract most frequently described are ovarian and endometrial cancers. Surgical findings and histopathological examination aimed at resolving this conundrum may be aided by molecular analyses, although they are too often inconclusive. High mitochondrial DNA (mtDNA) variability and its propensity to accumulate mutations has been proposed by our group as a tool to define clonality. We showed mtDNA sequencing to be informative in synchronous primary ovarian and endometrial cancer, detecting tumor-specific mutations in both lesions, ruling out independence of the two neoplasms, and indicating clonality. Furthermore, we tested this method in another frequent simultaneously detected gynecological lesion type, borderline ovarian cancer and their peritoneal implants, which may be monoclonal extra-ovarian metastases or polyclonal independent masses. The purpose of this review is to provide an update on the potential use of mtDNA sequencing in distinguishing independent and metastatic lesions in gynecological cancers, and to compare the efficiency of molecular analyses currently in use with this novel method.

scholarly journals Synchronous primary ovarian sex cord tumor and endometrial cancer

2016 ◽  
Author(s):  
S. A. Iqbal ◽  
H. Shukla ◽  
V. Jain ◽  
S. Giri ◽  
R. Sekhon ◽  
...  
Keyword(s):  
Genital Tract ◽  
Ovarian Tumor ◽  
Early Stage ◽  
Female Genital Tract ◽  
Low Grade ◽  
Primary Tumors ◽  
Stromal Tumors ◽  
Gynaecological Tumours ◽  
Sex Cord Stromal Tumors ◽  
Female Genital

Synchronous primary tumors of female genital tract are rare with a rate of about 0.7-1.8% of all gynaecological tumours. Most common primary tumours presenting as synchronous lesions are ovary and endometrium. However, sex cord stromal tumors are rare variety of primary ovarian tumor and synchronous with endometrium is even much rarer. These tumors are detected usually in younger, overweight, nulliparous and perimenopausal female. Synchronous primary tumors of endometrium and ovary have a better prognosis than the either of above alone because these are usually low grade and diagnosed at early stage. We present a report of four cases of synchronous endometrial and sex cord stromal tumors of ovary.

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