scholarly journals Synchronous primary ovarian sex cord tumor and endometrial cancer

2016 ◽  
Author(s):  
S. A. Iqbal ◽  
H. Shukla ◽  
V. Jain ◽  
S. Giri ◽  
R. Sekhon ◽  
...  
Keyword(s):  
Genital Tract ◽  
Ovarian Tumor ◽  
Early Stage ◽  
Female Genital Tract ◽  
Low Grade ◽  
Primary Tumors ◽  
Stromal Tumors ◽  
Gynaecological Tumours ◽  
Sex Cord Stromal Tumors ◽  
Female Genital

Synchronous primary tumors of female genital tract are rare with a rate of about 0.7-1.8% of all gynaecological tumours. Most common primary tumours presenting as synchronous lesions are ovary and endometrium. However, sex cord stromal tumors are rare variety of primary ovarian tumor and synchronous with endometrium is even much rarer. These tumors are detected usually in younger, overweight, nulliparous and perimenopausal female. Synchronous primary tumors of endometrium and ovary have a better prognosis than the either of above alone because these are usually low grade and diagnosed at early stage. We present a report of four cases of synchronous endometrial and sex cord stromal tumors of ovary.

Low-grade Serous Neoplasia of the Female Genital Tract

2019 ◽  
Vol 12 (2) ◽  
pp. 481-513 ◽  
Author(s):  
Ann K. Folkins ◽  
Teri A. Longacre
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Low Grade ◽  
Female Genital

scholarly journals Synchronous primary tumors of the endometrium and ovary

1970 ◽  
Vol 2 (3) ◽  
pp. 189-192 ◽  
Author(s):  
S Karki ◽  
U Chapagain
Keyword(s):  
Genital Tract ◽  
Endometrial Hyperplasia ◽  
Female Genital Tract ◽  
Premenopausal Women ◽  
Ovarian Tumors ◽  
University Teaching ◽  
Primary Tumors ◽  
Atypical Endometrial Hyperplasia ◽  
Ovarian Cancers ◽  
Female Genital

Background: Primary synchronous cancer of the female genital tract is a relatively uncommon. Simultaneously detected endometrial and ovarian malignancies constitute the commonest occurrence. A set of pathological criteria has been described to differentiate synchronous primaries from metastatic tumors. The purpose of this study was to characterize patients with synchronous primary endometrial and ovarian tumors. Materials and Methods: This was a retrospective study done in Department of Pathology, Tribhuwan University Teaching Hospital from September 2006 to August 2011. The datas were retrieved from computer database. Results: There were totally of 10 cases of simultaneously detected endometrial and ovarian cancers. Out of 10 cases, 7 cases were synchronous primary endometrial and ovarian cancers while three were metastatic. Median age at presentation was 47.4 years. Six (85.8%) of these patients presenting with dual primary tumors were premenopausal. Grade 1 histology was seen in 57% of endometrial and 42% of ovarian tumors. Atypical endometrial hyperplasia was found in 42.8% of cases while none of the cases showed endometriosis. Conclusion: Though limited by relatively small number of cases, younger and premenopausal women were predisposed to developing synchronous primary tumors of the endometrium and ovary. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6019 JPN 2012; 2(3): 189-192

Female genital tract rhabdomyosarcoma in childhood and adolescence: A single center experience.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e22518-e22518
Author(s):  
Inci Yaman Bajin ◽  
Tezer Kutluk ◽  
Ferah Yildiz ◽  
İbrahim Karnak ◽  
Berna Oğuz ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Clinical Features ◽  
Genital Tract ◽  
Early Stage ◽  
Female Genital Tract ◽  
Alveolar Type ◽  
Childhood And Adolescence ◽  
High Survival ◽  
Treatment Results ◽  
Female Genital

e22518 Background: Rhabdomyosarcoma is a rare tumor in children and adolescents, presenting 3% to 4% of all pediatric cancers. The female genital tract is considered as a favorable site of childhood RMS. The outcome has improved significantly during the last two decades, attributed to risk stratification and multimodality management of these challenging tumors. Here we present the clinical features and treatment results of girls with genital tract rhabdomyosarcoma to discuss. Methods: Fourteen girls with vaginal and uterine servical rhabdomyosarcoma younger than 18 years of age diagnosed and followed up between the years of 1995 and 2019 were included in this analysis. The clinical features and treatment results of patients were recorded from patient files and hospital information system retrospectively. Results: There were seven cases with vaginal and seven with uterin cervical carcinoma. All patients presented with polypoid masses protruding from the vagina. Median age of patients at diagnosis was 71 months (range 8-200 months). The IRS modified TNM staging was stage I for all the patients. All cases had embryonic type of RMS except one with alveolar type. All patients were treated with surgery and adjuvant chemotherapy, three received radiotherapy additionally. All achieved complete remission. Four patients experienced tumor relapse, 1 patient died with progressive disease. The median follow-up time was 75 months (7-271 months) for 13 patients who were alive with remission. Conclusions: Rhabdomyosarcoma is a rare sarcoma with a higher incidence in children and adolescents. With current treatment strategies, female genital tract rhabdomyosarcomas have a good prognosis. Favorable prognostic factors such as early stage at diagnosis and a favorable histology may contribute to the excellent observed survival. All parties who had involved on the care of these girls must be aware of the high survival with proper treatment to avoid treatment related morbidities and mortalities. Because of the rareness of the disease we wanted to share our experience.

scholarly journals Immune Pathogenesis of Asymptomatic Chlamydia trachomatis Infections in the Female Genital Tract

1995 ◽  
Vol 3 (4) ◽  
pp. 169-174 ◽  
Author(s):  
Steven S. Witkin
Keyword(s):  
Chlamydia Trachomatis ◽  
Genital Tract ◽  
Pregnancy Loss ◽  
Early Stage ◽  
Female Genital Tract ◽  
In Vivo Studies ◽  
Fallopian Tubes ◽  
Female Genital

Chlamydia trachomatis (CT) infections of the female genital tract, although frequently asymptomatic, are a major cause of fallopian-tube occlusion and infertility. Early stage pregnancy loss may also be due to an unsuspected and undetected CT infection. In vitro and in vivo studies have demonstrated that this organism can persist in the female genital tract in a form undetectable by culture. The mechanism of tubal damage as well as the rejection of an embryo may involve an initial immune sensitization to the CT 60 kD heat shock protein (HSP), followed by a reactivation of HSP-sensitized lymphocytes in response to the human HSP and the subsequent release of inflammatory cytokines. The periodic induction of human HSP expression by various microorganisms or by noninfectious mechanisms in the fallopian tubes of women sensitized to the CT HSP may eventually result in tubal scarring and occlusion. Similarly, an immune response to human HSP expression during the early stages of pregnancy may interfere with the immune regulatory mechanisms required for the maintenance of a semiallogeneic embryo.

Osteosarcoma of the Myometrium Synchronous with Bilateral Papillary Cystadenocarcinoma of the Ovary and Papillary Adenocarcinoma of the Cervix

1988 ◽  
Vol 74 (2) ◽  
pp. 227-231 ◽  
Author(s):  
Fulvio Basolo ◽  
Raffaele Pingitore ◽  
Angelo Gadducci
Keyword(s):  
Genital Tract ◽  
Rare Case ◽  
Female Genital Tract ◽  
Papillary Adenocarcinoma ◽  
Pathological Features ◽  
Primary Tumors ◽  
The World ◽  
Clinical And Pathological Features ◽  
Female Genital

We report an extremely rare case of a 60-year-old woman with myometrial osteosarcoma associated with bilateral papillary cystadenocarcinoma of the ovary and papillary adenocarcinoma of the cervix. The uterine osteosarcoma is the seventh case reported in the world, while it is the second case of syncronous triple primary tumors of the upper female genital tract. Clinical and pathological features of previously reported cases of uterine osteosarcoma and triple primary neoplasias of the upper female genital tract are critically reviewed.

Synchronous primary tumors of the female genital tract: a single center experience

2008 ◽  
Vol 279 (5) ◽  
pp. 667-672 ◽  
Author(s):  
Tayfun Gungor ◽  
Mine Kanat-Pektas ◽  
Emin Ustunyurt ◽  
Leyla Mollamahmutoglu
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Single Center ◽  
Primary Tumors ◽  
Single Center Experience ◽  
Female Genital

scholarly journals Synchronous endometrial and ovarian cancer: a rare presentation

2020 ◽  
Vol 9 (9) ◽  
pp. 3889
Author(s):  
Reena Yadav ◽  
Nishtha Jaiswal ◽  
Ruby Yadav ◽  
Manisha Kumar
Keyword(s):  
Genital Tract ◽  
Obese Woman ◽  
Female Genital Tract ◽  
Good Prognosis ◽  
Low Grade ◽  
Rare Presentation ◽  
Gynecological Malignancies ◽  
Histologic Types ◽  
Better Than ◽  
Female Genital

Synchronous primary cancers are relatively uncommon in the general population. About 0.5 -1.7% of gynecological malignancies have synchronous primary cancer of female genital tract. Amongst the synchronous gynecological malignancies synchronous endometrioid carcinoma is most common and has good prognosis. Patients with synchronous endometrioid tumors of endometrium and ovary are usually younger, have low grade number, and their prognosis is better than other histologic types. The authors are presenting a case of 38 years old nulliparous obese woman with pain in abdomen and heavy menstrual bleeding for a duration of four months. The MRI pelvis was suggestive of well defined, lobulated, complex, solid cystic multiseptated lesion measuring 8.8×7.7×8.8 cm in right adnexa, with anteverted uterus, and a bulky indistinct emdomyometrial junction. Histopathology revealed synchronous endometrial carcinoma of both uterus and ovary.

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Mullerian Adenosarcoma of the Female Genital Tract

2014 ◽  
Vol 24 (Supp 3) ◽  
pp. S78-S82 ◽  
Author(s):  
Michael Leonard Friedlander ◽  
Alan Covens ◽  
Rosalind M. Glasspool ◽  
Felix Hilpert ◽  
Gunnar Kristensen ◽  
...  
Keyword(s):  
Genital Tract ◽  
Current Knowledge ◽  
Gynecologic Cancer ◽  
Female Genital Tract ◽  
Endometrial Stromal Sarcoma ◽  
Good Prognosis ◽  
Low Grade ◽  
High Grade ◽  
Stromal Sarcoma ◽  
Female Genital

Mullerian adenosarcomas of the female genital tract are rare malignancies, originally described in the uterus, the most common site of origin, but they may also arise in extrauterine locations. Uterine adenosarcomas make up 5% of uterine sarcomas and tend to occur in postmenopausal women. They are usually low-grade tumors and are characterized by a benign epithelial component with a malignant mesenchymal component, which is typically a low-grade endometrial stromal sarcoma but can also be a high-grade sarcoma. Tumors that exhibit a high-grade sarcomatous overgrowth have a worse outcome. Adenosarcomas have been described as being midway along the spectrum between benign adenofibromas and carcinosarcomas. They generally have a good prognosis with the exception of deeply invasive tumors or those with high-grade sarcomatous overgrowth. Extrauterine adenosarcomas also have a higher risk for recurrence. In view of their rarity, there have not been any clinical trials in mullerian adenosarcomas and relatively little research. This article reviews the current knowledge and provides recommendation for the management of mullerian adenosarcomas.

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