Synchronous primary tumors of the endometrium and ovary

Background: Primary synchronous cancer of the female genital tract is a relatively uncommon. Simultaneously detected endometrial and ovarian malignancies constitute the commonest occurrence. A set of pathological criteria has been described to differentiate synchronous primaries from metastatic tumors. The purpose of this study was to characterize patients with synchronous primary endometrial and ovarian tumors. Materials and Methods: This was a retrospective study done in Department of Pathology, Tribhuwan University Teaching Hospital from September 2006 to August 2011. The datas were retrieved from computer database. Results: There were totally of 10 cases of simultaneously detected endometrial and ovarian cancers. Out of 10 cases, 7 cases were synchronous primary endometrial and ovarian cancers while three were metastatic. Median age at presentation was 47.4 years. Six (85.8%) of these patients presenting with dual primary tumors were premenopausal. Grade 1 histology was seen in 57% of endometrial and 42% of ovarian tumors. Atypical endometrial hyperplasia was found in 42.8% of cases while none of the cases showed endometriosis. Conclusion: Though limited by relatively small number of cases, younger and premenopausal women were predisposed to developing synchronous primary tumors of the endometrium and ovary. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6019 JPN 2012; 2(3): 189-192

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Synchronous primary ovarian sex cord tumor and endometrial cancer

10.1055/s-0039-1685384 ◽

2016 ◽

Author(s):

S. A. Iqbal ◽

H. Shukla ◽

V. Jain ◽

S. Giri ◽

R. Sekhon ◽

...

Keyword(s):

Genital Tract ◽

Ovarian Tumor ◽

Early Stage ◽

Female Genital Tract ◽

Low Grade ◽

Primary Tumors ◽

Stromal Tumors ◽

Gynaecological Tumours ◽

Sex Cord Stromal Tumors ◽

Female Genital

Synchronous primary tumors of female genital tract are rare with a rate of about 0.7-1.8% of all gynaecological tumours. Most common primary tumours presenting as synchronous lesions are ovary and endometrium. However, sex cord stromal tumors are rare variety of primary ovarian tumor and synchronous with endometrium is even much rarer. These tumors are detected usually in younger, overweight, nulliparous and perimenopausal female. Synchronous primary tumors of endometrium and ovary have a better prognosis than the either of above alone because these are usually low grade and diagnosed at early stage. We present a report of four cases of synchronous endometrial and sex cord stromal tumors of ovary.

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Osteosarcoma of the Myometrium Synchronous with Bilateral Papillary Cystadenocarcinoma of the Ovary and Papillary Adenocarcinoma of the Cervix

Tumori Journal ◽

10.1177/030089168807400219 ◽

1988 ◽

Vol 74 (2) ◽

pp. 227-231 ◽

Cited By ~ 3

Author(s):

Fulvio Basolo ◽

Raffaele Pingitore ◽

Angelo Gadducci

Keyword(s):

Genital Tract ◽

Rare Case ◽

Female Genital Tract ◽

Papillary Adenocarcinoma ◽

Pathological Features ◽

Primary Tumors ◽

The World ◽

Clinical And Pathological Features ◽

Female Genital

We report an extremely rare case of a 60-year-old woman with myometrial osteosarcoma associated with bilateral papillary cystadenocarcinoma of the ovary and papillary adenocarcinoma of the cervix. The uterine osteosarcoma is the seventh case reported in the world, while it is the second case of syncronous triple primary tumors of the upper female genital tract. Clinical and pathological features of previously reported cases of uterine osteosarcoma and triple primary neoplasias of the upper female genital tract are critically reviewed.

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Synchronous primary tumors of the female genital tract: a single center experience

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-008-0800-7 ◽

2008 ◽

Vol 279 (5) ◽

pp. 667-672 ◽

Cited By ~ 7

Author(s):

Tayfun Gungor ◽

Mine Kanat-Pektas ◽

Emin Ustunyurt ◽

Leyla Mollamahmutoglu

Keyword(s):

Genital Tract ◽

Female Genital Tract ◽

Single Center ◽

Primary Tumors ◽

Single Center Experience ◽

Female Genital

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Female genital tract tuberculosis in Tribhuvan University Teaching Hospital: A retrospective one year histopathological study

Nepal Journal of Obstetrics and Gynaecology ◽

10.3126/njog.v2i2.1452 ◽

1970 ◽

Vol 2 (2) ◽

pp. 29-34

Author(s):

Abhimanyu Jha ◽

Gita Sayami ◽

Ram Adhikari ◽

Roona Jha ◽

Rashmi Chaudhari

Keyword(s):

Teaching Hospital ◽

Genital Tract ◽

Female Genital Tract ◽

Clinical Findings ◽

University Teaching ◽

Histopathological Study ◽

Fallopian Tubes ◽

Peritoneal Biopsy ◽

One Year ◽

Female Genital

Aim: To determine frequency of female genital tract (FGT) tuberculosis (TB) in the gynecological biopsies received in the Department of Histopathology of Tribhuvan University Teaching Hospital. Methods: This is a retrospective study conducted in the Department of Pathology of Tribhuvan University Teaching Hospital. Histopathology records of one year (14th April 2006 to 13th April 2007) were retrieved and searched for the cases of female genital tract TB. Relevant histopathological findings and clinical data were recorded and analyzed. Results: We analyzed 5696 histopathological cases during one year period for FGT tuberculosis. There were 1565 cases of gynecological biopsy and 9 cases were diagnosed as FGT tuberculosis based on histopathological and clinical findings. Ovarian tuberculosis was seen in three cases, bilateral fallopian tubes were involved in 2 cases and endometrial tuberculosis was diagnosed in 2 cases. 3 cases of omental biopsy and 1 case of peritoneal biopsy showed tubercular granulomas. Conclusion: FGT tuberculosis was usually seen in age 16-28 years and constituted 0.57% of total gynecological cases and 0.15% of total biopsies. Fallopian tubes, ovaries and endometrium were affected with the involvement of peritoneum or omentum, common event being tubercular endosalpingitis. Histopathology in association with clinical findings still remains gold standard for the diagnosis of FGT tuberculosis in our country despite advancement in diagnostic modalities; however, incidental histological detection in clinically unanticipated cases is not an uncommon event. Key Words: Female genital tract TB, histopathology, clinical findings. doi:10.3126/njog.v2i2.1452 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 29 - 34

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Synchronous papillary endometrial and ovarian cancer in a 64-year-old woman

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20215113 ◽

2021 ◽

Vol 11 (1) ◽

pp. 252

Author(s):

Ganesh B. Bharaswadkar ◽

Nalan Babacan

Keyword(s):

Ovarian Cancer ◽

Genital Tract ◽

Female Genital Tract ◽

Ovarian Tumors ◽

Fallopian Tubes ◽

Metachronous Cancer ◽

Morphological Unit ◽

Younger Age ◽

Synchronous Malignancies ◽

Female Genital

Obesity, nulliparity, and comparatively younger age may attribute a “hormonal field effect” which leads to the development of synchronous endometrioid cancers. The morphological unit consisting of the uterus, fallopian tubes, and ovary as part of the Mullerian system may explain the synchronous appearance of these malignancies. Synchronous endometrial and ovarian cancer (SEOC) is defined as the simultaneous presence of these dual cancers at the time of diagnosis as opposed to metachronous cancer where these two cancers are diagnosed at different chronologic time points. Synchronous malignancies in the female genital tract are very rare entities. Synchronous endometrial and ovarian tumors must be differentiated from either primary endometrium or ovarian tumors with metastasis. The landmark criteria for diagnosing such cases have been laid down by Ulbright and Roth.

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Targeted therapy with monoclonal antibodies: Do we observe progress in the management of female genital tract cancers?

Postępy Higieny i Medycyny Doświadczalnej ◽

10.5604/01.3001.0011.7338 ◽

2018 ◽

Vol 72 ◽

pp. 192-204

Author(s):

Jacek R. Wilczyński ◽

Marek Nowak ◽

Miłosz Wilczyński

Keyword(s):

Ovarian Cancer ◽

Monoclonal Antibodies ◽

Targeted Therapy ◽

Genital Tract ◽

Female Genital Tract ◽

Malignant Ascites ◽

Peritoneal Cancer ◽

Ovarian Cancers ◽

Intraperitoneal Treatment ◽

Female Genital

Targeted therapy with monoclonal antibodies (moAbs) has become a valuable supplementation for classic chemo- and radiotherapy. The first part of this review presents in a condensed way the characteristics and mechanism of action of moAbs most commonly used and/or tested for therapy of female genital tract malignancies, including: bevacizumab (anti-VEGF-A moAb), cetuximab (anti-EGFR moAb), trastuzumab (anti-ErbB2/HER2 moAb), catumaxomab (anti-EpCAM/anti-CD3 moAb), oregovomab (anti-MUC16 moAb) and farletuzumab (anti-FR-α moAb). The second part of the review discusses the results of the recent clinical trials devoted to the usefulness of moAbs in the management of cervical, endometrial and ovarian cancers. The unquestionable progress in this field has made possible the introduction of bevacizumab for the treatment of advanced ovarian, Fallopian tube or peritoneal cancer, as well as advanced, recurrent or metastatic cervical cancer. Similarly, catumaxomab has been registered for the intraperitoneal treatment of malignant ascites in EpCAM positive ovarian cancer when standard therapy is no longer available.

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