Herpes Simplex Virus Proctitis Masquerading as Rectal Cancer

Herpes simplex virus (HSV) is the leading cause of proctitis in HIV-infected individuals. However, no cases of rectal masses secondary to HSV infection have been reported to date. Herein, we present the case of a 45-year-old man with HIV infection who developed rectal pain and bleeding, along with dysuria and voiding difficulty. Colonoscopy revealed proctitis and a rectal mass with features concerning for rectal cancer. Histologic sections of the rectal mass biopsy demonstrated colorectal mucosa with viral cytopathic changes, ulceration, granulation tissue, marked inflammatory infiltrate, and fibrinopurulent exudate. Immunohistochemistry for herpes simplex virus-1 was positive in epithelial cells demonstrating a viral cytopathic effect. The patient was treated with valacyclovir for 3 weeks, which led to complete resolution of his symptoms. Follow-up sigmoidoscopy at 6 months did not show any masses. Our case illustrates the importance of considering HSV in the differential diagnosis of rectal masses. We advocate the routine use of viral immunohistochemistry for the evaluation of rectal tumors, especially in patients with clinical manifestations and endoscopic findings consistent with proctitis.

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Herpes-Simplex-Virus 1 pneumonia in the immunocompromised host: High-resolution CT patterns in correlation to outcome and follow-up

European Journal of Radiology ◽

10.1016/j.ejrad.2011.03.014 ◽

2012 ◽

Vol 81 (4) ◽

pp. e415-e420 ◽

Cited By ~ 8

Author(s):

H. Brodoefel ◽

M. Vogel ◽

D. Spira ◽

C. Faul ◽

R. Beck ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

High Resolution ◽

Immunocompromised Host ◽

Herpes Simplex Virus 1 ◽

High Resolution Ct ◽

Simplex Virus

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Herpes Simplex Virus Keratitis in a University Tertiary Referral Centre – Clinical Features and Surgical Approaches

Klinische Monatsblätter für Augenheilkunde ◽

10.1055/a-1306-0896 ◽

2021 ◽

Author(s):

Raul Alfaro Rangel ◽

Sabine Lepper ◽

Nóra Szentmáry ◽

Achim Langenbucher ◽

Berthold Seitz

Keyword(s):

Visual Acuity ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Clinical Manifestations ◽

Tertiary Referral ◽

Main Indication ◽

Emergency Procedures ◽

Common Diagnosis ◽

Simplex Virus

Abstract Purpose To assess prevalence, clinical manifestations, required keratoplasties, follow-up, and outcome in patients with Herpes Simplex Virus Keratitis (HSK) attending a University Tertiary Referral Center. Design Retrospective (12 years), descriptive, observational study. Methods A total of 817 eyes with clinical diagnosis of HSK from 779 patients were classified by the type of presentation. We gathered data on the visual acuity, refraction, IOP, and required surgical procedures. Results Stromal involvement including scars represented the most common diagnosis in our department and the main indication of penetrating keratoplasty (PKP). Epithelial keratitis (16%) presented with the best visual acuity at the first visit. Necrotizing keratitis represented 17% of the patients, 78% of whom required PKP; this group also had the worst visual acuity at first examination and was the main indication for emergency PKP. Among all eyes, 288 (35%) required PKP. A total of 230 (28%) PKPs were elective procedures and 58 (7%) PKPs were performed as emergency procedures. Two patients with quiet endothelial decompensations after recurrent HSV endotheliitis were treated with DMEK and had good visual outcomes without HSV recurrence at last follow-up. Conclusions HSK is a prevalent disease with severe consequences when not treated appropriately and on time. Even when making an accurate diagnosis, the disease can be extremely aggressive, with all the implications it brings to the patients and health system. Elective PKP had better outcomes in terms of visual acuity and clear graft percentage compared to emergency PKP.

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Anti-NMDAR autoimmune encephalitis in children and herpes simplex virus-1

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) ◽

10.21508/1027-4065-2019-64-3-17-27 ◽

2019 ◽

Vol 64 (3) ◽

pp. 17-27

Author(s):

E. Yu. Skripchenko ◽

G. F. Zheleznikova ◽

N. V. Skripchenko ◽

L. A. Alekseeva ◽

A. V. Surovtseva

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Herpes Simplex Virus Infection ◽

Clinical Manifestations ◽

Autoimmune Encephalitis ◽

Herpes Simplex Virus 1 ◽

Nmdar Encephalitis ◽

Adults And Children ◽

The Central Nervous System ◽

Simplex Virus

The review focuses on autoimmune encephalitis with antibodies to NMDA receptors, previously unknown autoimmune disease of the central nervous system, described in 2007. Anti-NMDAR encephalitis develops in adults and children, due to the tumor process and without it, it is manifested by characteristic syndrome of neurological and mental disorders. The authors separate anti-NMDAR encephalitis, which develops after the resolution of encephalitis caused by the herpes simplex virus-1. They describe the clinical manifestations of anti-NMDAR encephalitis in children and the effectiveness of early immunotherapy. Perspectively they discuss the pathogenesis of the disease, as well as the connection of herpes simplex virus infection and the development of anti-NMDAR encephalitis.

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The lack of association between herpes simplex virus 1 or Toxoplasma gondii infection and cognitive decline in the general population: An 11-year follow-up study

Brain Behavior and Immunity ◽

10.1016/j.bbi.2018.11.016 ◽

2019 ◽

Vol 76 ◽

pp. 159-164 ◽

Cited By ~ 5

Author(s):

M. Torniainen-Holm ◽

J. Suvisaari ◽

M. Lindgren ◽

T. Härkänen ◽

F. Dickerson ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Toxoplasma Gondii ◽

General Population ◽

Cognitive Decline ◽

Herpes Simplex Virus 1 ◽

Follow Up Study ◽

Toxoplasma Gondii Infection ◽

Simplex Virus

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Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100140579 ◽

1995 ◽

Vol 53 ◽

pp. 840-841

Author(s):

Z. Hong Zhou ◽

Jing He ◽

Joanita Jakana ◽

J. D. Tatman ◽

Frazer J. Rixon ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

3D Structure ◽

Structure Study ◽

Herpes Simplex Virus 1 ◽

Shell Proteins ◽

Life Threatening ◽

Infected Cells ◽

Simplex Virus ◽

Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

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