Herpes-Simplex-Virus 1 pneumonia in the immunocompromised host: High-resolution CT patterns in correlation to outcome and follow-up

Herpes simplex virus (HSV) is the leading cause of proctitis in HIV-infected individuals. However, no cases of rectal masses secondary to HSV infection have been reported to date. Herein, we present the case of a 45-year-old man with HIV infection who developed rectal pain and bleeding, along with dysuria and voiding difficulty. Colonoscopy revealed proctitis and a rectal mass with features concerning for rectal cancer. Histologic sections of the rectal mass biopsy demonstrated colorectal mucosa with viral cytopathic changes, ulceration, granulation tissue, marked inflammatory infiltrate, and fibrinopurulent exudate. Immunohistochemistry for herpes simplex virus-1 was positive in epithelial cells demonstrating a viral cytopathic effect. The patient was treated with valacyclovir for 3 weeks, which led to complete resolution of his symptoms. Follow-up sigmoidoscopy at 6 months did not show any masses. Our case illustrates the importance of considering HSV in the differential diagnosis of rectal masses. We advocate the routine use of viral immunohistochemistry for the evaluation of rectal tumors, especially in patients with clinical manifestations and endoscopic findings consistent with proctitis.

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Herpes simplex virus pneumonia: high-resolution CT findings

British Journal of Radiology ◽

10.1259/bjr/51409455 ◽

2010 ◽

Vol 83 (991) ◽

pp. 585-589 ◽

Cited By ~ 26

Author(s):

S Chong ◽

T S Kim ◽

E Y Cho

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

High Resolution ◽

High Resolution Ct ◽

Ct Findings ◽

Virus Pneumonia ◽

Simplex Virus

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The lack of association between herpes simplex virus 1 or Toxoplasma gondii infection and cognitive decline in the general population: An 11-year follow-up study

Brain Behavior and Immunity ◽

10.1016/j.bbi.2018.11.016 ◽

2019 ◽

Vol 76 ◽

pp. 159-164 ◽

Cited By ~ 5

Author(s):

M. Torniainen-Holm ◽

J. Suvisaari ◽

M. Lindgren ◽

T. Härkänen ◽

F. Dickerson ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Toxoplasma Gondii ◽

General Population ◽

Cognitive Decline ◽

Herpes Simplex Virus 1 ◽

Follow Up Study ◽

Toxoplasma Gondii Infection ◽

Simplex Virus

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Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100140579 ◽

1995 ◽

Vol 53 ◽

pp. 840-841

Author(s):

Z. Hong Zhou ◽

Jing He ◽

Joanita Jakana ◽

J. D. Tatman ◽

Frazer J. Rixon ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

3D Structure ◽

Structure Study ◽

Herpes Simplex Virus 1 ◽

Shell Proteins ◽

Life Threatening ◽

Infected Cells ◽

Simplex Virus ◽

Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

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