scholarly journals Heart Rate Dynamics in Patients with Obstructive Sleep Apnea: Heart Rate Variability and Entropy

Entropy ◽  
2019 ◽  
Vol 21 (10) ◽  
pp. 927
Author(s):  
Lulu Zhang ◽  
Mingyu Fu ◽  
Fengguo Xu ◽  
Fengzhen Hou ◽  
Yan Ma
Keyword(s):  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Heart Rate Variability ◽  
Sleep Apnea ◽  
Apnea Hypopnea Index ◽  
Cross Sectional ◽  
Sleep Study ◽  
Ecg Signals ◽  
Potential Association ◽  
Obstructive Sleep

Background: Obstructive sleep apnea (OSA), a highly prevalent sleep disorder, is closely related to cardiovascular disease (CVD). Our previous work demonstrated that Shannon entropy of the degree distribution (EDD), obtained from the network domain of heart rate variability (HRV), might be a potential indicator for CVD. Method: To investigate the potential association between OSA and EDD, OSA patients and healthy controls (HCs) were identified from a sleep study database. Then EDD was calculated from electrocardiogram (ECG) signals during sleep, followed by cross-sectional comparisons between OSA patients and HCs, and longitudinal comparisons from baseline to follow-up visits. Furthermore, for OSA patients, the association between EDD and OSA severity, measured by apnea-hypopnea index (AHI), was also analyzed. Results: Compared with HCs, OSA patients had significantly increased EDD during sleep. A positive correlation between EDD and the severity of OSA was also observed. Although the value of EDD became larger with aging, it was not OSA-specified. Conclusion: Increased EDD derived from ECG signals during sleep might be a potential dynamic biomarker to identify OSA patients from HCs, which may be used in screening OSA with high risk before polysomnography is considered.

scholarly journals P.2.35 Heart rate variability and sleep-related breathing disorders in commercial drivers

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A96.1-A96
Author(s):  
Wei-te Wu ◽  
Yu-Jen Lin ◽  
Saou-Hsing Liou
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sleep Apnea ◽  
Fasting Blood Glucose ◽  
Apnea Hypopnea Index ◽  
Sleep Related Breathing Disorders ◽  
Cross Sectional ◽  
Breathing Disorders ◽  
Obstructive Sleep ◽  
Commercial Drivers

BackgroundSleep-related breathing disorders, such as obstructive sleep apnea (OSA), seems to have an important influence on the autonomic nervous function on the heart, and associated with cardiovascular mortality. Therefore, we assessed the relations of sleep apnea-related parameters with 5 min heart rate variability (HRV) in a large cohort of male commercial drivers.MethodsThis cross-sectional study recruited 245 male bus drivers from one transportation company in Taiwan. Each participant was evaluated by a polysomnography (PSG) test and by blood lipids examination. Severity of OSA was categorized according to the apnea-hypopnea index (AHI). In addition, short-term HRV was tested.ResultsSubjects were categorized into severe OSA group (n=44; 17.9%), moderate and mild OSA group (n=117; 47.8%), and non-OSA group (n=84; 34.3%). AHI had negative correlations with SDNN (β=−0.075, p=0.007) and RMSSD (β=−0.121, p<0.001), adjusting for age, body mass index, smoking, drinking, systolic blood pressure, HDL, and fasting blood glucose. RMSSD level was decreased with severe OSA (β=−0.266, p=0.042) even adjusting for confounders.ConclusionsThe findings showed a low level of RMSSD in OSA among commercial drivers, especially in the severe group category. Decreased SDNN and RMSSD levels are associated with AHI level in commercial drivers, suggesting that they are tightly linked with autonomic dysfunction.

scholarly journals Benefits of oxytocin administration in obstructive sleep apnea

2017 ◽  
Vol 313 (5) ◽  
pp. L825-L833 ◽  
Author(s):  
Vivek Jain ◽  
Joseph Marbach ◽  
Shawn Kimbro ◽  
David C. Andrade ◽  
Arad Jain ◽  
...  
Keyword(s):  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Heart Rate Variability ◽  
Sleep Apnea ◽  
Sleep Time ◽  
Apnea Hypopnea Index ◽  
Beneficial Effects ◽  
Oxytocin Receptors ◽  
Obstructive Sleep ◽  
Patient Reported

Activation of oxytocin receptors has shown benefits in animal models of obstructive sleep apnea (OSA). We tested if nocturnal oxytocin administration could have beneficial effects in OSA patients. Eight patients diagnosed with OSA were administered intranasal oxytocin (40 IU). Changes in cardiorespiratory events during sleep, including apnea and hypopnea durations and frequency, risk of event-associated arousals, and heart rate variability, were assessed. Oxytocin significantly increased indexes of parasympathetic activity, including heart rate variability, total sleep time, and the postpolysommogram sleep assessment score, an index of self-reported sleep satisfaction. Although the apnea-hypopnea index was not significantly changed with oxytocin administration, when apnea and hypopnea events were compared independently, the frequency of hypopneas, but not apneas, was significantly ( P ≤ 0.005) decreased with oxytocin treatment. Both apneas and hypopneas were significantly shortened in duration with oxytocin treatment. Oxytocin treatment significantly decreased the percent of apnea and hypopnea events that were accompanied with an arousal. Oxytocin administration has the potential to restore cardiorespiratory homeostasis and reduce some clinically important (objective and patient-reported) adverse events that occur with OSA. Additional studies are needed to further understand the mechanisms by which oxytocin promotes these changes in cardiorespiratory and autonomic function in OSA patients.

scholarly journals Comparing REM- and NREM-Related Obstructive Sleep Apnea in Jordan: A Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
K. Al Oweidat ◽  
S. A. AlRyalat ◽  
M. Al-Essa ◽  
N. Obeidat
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Upper Airway ◽  
Cross Sectional Study ◽  
Apnea Hypopnea Index ◽  
Cross Sectional ◽  
Sleep Study ◽  
Broad Definition ◽  
Obstructive Sleep ◽  
Strict Definition

Obstructive sleep apnea (OSA) is a common disorder that includes an intermittent mechanical obstruction of the upper airway during sleep, which can occur either during rapid eye movement (REM) phase or non-REM (NREM) phase. In this study, we aim to evaluate the differences in demographic and polysomnographic features between REM- and NREM-related OSA in a Jordanian sample, using both the broad and the restricted definitions of REM-related OSA. All patients who were referred due to clinical suspicion of OSA and underwent sleep study were screened. We included patients with a diagnosis of OSA who had Apnea-Hypopnea Index (AHI) greater than or equal to five. We classified patients into REM-related OSA according to either the broad definition (AHIREM/AHINREM ≥ 2) or the strict definition (AHIREM > 5 and AHINREM < 5 with a total REM sleep duration of at least 30 minutes), and patients with AHIREM/AHINREM less than two were classified as NREM-related OSA. A total of 478 patients were included in this study with a mean age of 55.3 years (±12.6). According to the broad definition of REM-related OSA, 86 (18%) of OSA patients were classified as having REM-related OSA compared to only 13 (2.7%) patients according to the strict definition. Significant differences were found between both NREM-related OSA and REM-related OSA according to the broad and to the strict definitions for arousal index (p<0.001 and p<0.032), respectively, duration of saturation below 90% (p<0.001 for both), and saturation nadir (p<0.036 and p<0.013), respectively. No significant differences were found between this group and other OSA patients regarding age, BMI, ESS, and snoring. Our study showed that the stricter the definition for REM-related OSA, the milder the associated clinical changes.

scholarly journals The effect of sleep apnea severity on cardiac autonomic activity during night time in obstructive sleep apnea patients

2016 ◽  
Vol 134 (5) ◽  
pp. 430-436 ◽  
Author(s):  
Gulay Ozkececi ◽  
Sevinc Sarinc Ulasli ◽  
Onder Akci ◽  
Alaettin Avsar ◽  
Mehmet Unlu ◽  
...  
Keyword(s):  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiac Function ◽  
Cross Sectional Study ◽  
Apnea Hypopnea Index ◽  
Night Time ◽  
Cross Sectional ◽  
Obstructive Sleep ◽  
The Impact

ABSTRACT CONTEXT AND OBJECTIVE: Impaired autonomic cardiac function is an important consequence of obstructive sleep apnea (OSA). This impairment is mainly due to intermittent hypoxia episodes following apneas. However, the impact of apnea severity on autonomic cardiac function remains unclear. The aim of this study was to evaluate the relationship between the severity of sleep apnea and heart rate turbulence (HRT) and heart rate variability (HRV) in OSA. DESIGN AND SETTING: Observational cross-sectional study conducted in the Departments of Cardiology and Pulmonary Diseases, Afyon Kocatepe University, Turkey. METHODS: 106 patients with OSA and 27 healthy volunteers were enrolled. Based on apnea hypopnea index (AHI) values, obstructive sleep apnea severity was classified as follows: mild OSA (AHI ≥ 5 and < 15), moderate OSA (AHI ≥ 15 and ≤ 30) and severe OSA (AHI > 30). HRV and HRT parameters were assessed via 24-hour digital Holter electrocardiogram recordings for all subjects. RESULTS: HRV and HRT results were significantly lower among OSA patients than among control subjects (P < 0.05). However, there were no significant differences in HRT and HRV between the three patient subgroups. Correlations did emerge between AHI and the NN-interval parameter RMSSD and between oxygen desaturation and turbulence slope (respectively: r = -0.22, P = 0.037; and r = -0.28, P = 0.025). CONCLUSION: HRT and HRV results deteriorate in OSA. Correlations between apnea severity and these parameters seem to be present.

Obstructive Sleep Apnea and Heart Rate Variability in Male Patients with Metabolic Syndrome: Cross-Sectional Study

2014 ◽  
Vol 12 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Orsolya Véber ◽  
Zsofia Lendvai ◽  
Katalin Zsuzsanna Ronai ◽  
Andrea Dunai ◽  
Rezso Zoller ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Heart Rate Variability ◽  
Sleep Apnea ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Obstructive Sleep ◽  
Male Patients

scholarly journals Heart Rate Variability during Wakefulness as a Marker of Obstructive Sleep Apnea Severity

SLEEP ◽  
2021 ◽  
Author(s):  
Hua Qin ◽  
Brendan T Keenan ◽  
Diego R Mazzotti ◽  
Fernando Vaquerizo-Villar ◽  
Jan F Kraemer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Heart Rate Variability ◽  
Sleep Apnea ◽  
Frequency Domain ◽  
Time Domain ◽  
Analysis Of Covariance ◽  
Sleep Study ◽  
Obstructive Sleep ◽  
Non Linear

Abstract Study Objectives Patients with obstructive sleep apnea (OSA) exhibit heterogeneous heart rate variability (HRV) during wakefulness and sleep. We investigated the influence of OSA severity on HRV parameters during wakefulness in a large international clinical sample. Methods 1247 subjects (426 without OSA and 821 patients with OSA) were enrolled from the Sleep Apnea Global Interdisciplinary Consortium. HRV parameters were calculated during a 5-minute wakefulness period with spontaneous breathing prior to the sleep study, using time-domain, frequency-domain and non-linear methods. Differences in HRV were evaluated among groups using analysis of covariance, controlling for relevant covariates. Results Patients with OSA showed significantly lower time-domain variations and less complexity of heartbeats compared to individuals without OSA. Those with severe OSA had remarkably reduced HRV compared to all other groups. Compared to non-OSA patients, those with severe OSA had lower HRV based on SDNN (adjusted mean: 37.4 vs. 46.2 ms; p&lt;0.0001), RMSSD (21.5 vs. 27.9 ms; p&lt;0.0001), ShanEn (1.83 vs. 2.01; p&lt;0.0001), and Forbword (36.7 vs. 33.0; p=0.0006). While no differences were found in frequency-domain measures overall, among obese patients there was a shift to sympathetic dominance in severe OSA, with a higher LF/HF ratio compared to obese non-OSA patients (0.97 vs. 0.63; p=0.009). Conclusions Time-domain and non-linear HRV measures during wakefulness were associated with OSA severity, with severe patients having remarkably reduced and less complex HRV. Frequency-domain measures show a shift to sympathetic dominance only in obese OSA patients. Thus, HRV during wakefulness could provide additional information about cardiovascular physiology in OSA patients.

scholarly journals Subjective and Objective Appraisal of Activity in Adults with Obstructive Sleep Apnea

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Eileen R. Chasens ◽  
Susan M. Sereika ◽  
Martin P. Houze ◽  
Patrick J. Strollo
Keyword(s):  
Physical Activity ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Epworth Sleepiness Scale ◽  
Functional Outcomes ◽  
Apnea Hypopnea Index ◽  
Sleep Study ◽  
Obstructive Sleep ◽  
Subjective Sleepiness ◽  
Aging Adults

Objective.This study examined the association between obstructive sleep apnea (OSA), daytime sleepiness, functional activity, and objective physical activity.Setting.Subjects (N=37) being evaluated for OSA were recruited from a sleep clinic.Participants. The sample was balanced by gender (53% male), middle-aged, primarily White, and overweight or obese with a mean BMI of 33.98 (SD=7.35;median BMI=32.30). Over 40% reported subjective sleepiness (Epworth Sleepiness Scale (ESS) ≥10) and had OSA (78% with apnea + hypopnea index (AHI) ≥5/hr).Measurements.Evaluation included questionnaires to evaluate subjective sleepiness (Epworth Sleepiness Scale (ESS)) and functional outcomes (Functional Outcomes of Sleep Questionnaire (FOSQ)), an activity monitor, and an overnight sleep study to determine OSA severity.Results.Increased subjective sleepiness was significantly associated with lower scores on the FOSQ but not with average number of steps walked per day. A multiple regression analysis showed that higher AHI values were significantly associated with lower average number of steps walked per day after controlling patient's age, sex, and ESS.Conclusion.Subjective sleepiness was associated with perceived difficulty in activity but not with objectively measured activity. However, OSA severity was associated with decreased objective physical activity in aging adults.

scholarly journals Symbolic dynamics marker of heart rate variability combined with clinical variables enhance obstructive sleep apnea screening

2014 ◽  
Vol 24 (2) ◽  
pp. 024404 ◽  
Author(s):  
A. G. Ravelo-García ◽  
P. Saavedra-Santana ◽  
G. Juliá-Serdá ◽  
J. L. Navarro-Mesa ◽  
J. Navarro-Esteva ◽  
...  
Keyword(s):  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Heart Rate Variability ◽  
Sleep Apnea ◽  
Symbolic Dynamics ◽  
Clinical Variables ◽  
Obstructive Sleep
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