scholarly journals Towards Precision Medicine: Inclusion of Sex and Gender Aspects in COVID-19 Clinical Studies—Acting Now before It Is Too Late—A Joint Call for Action

Author(s):  
Evelyne Bischof ◽  
Sabine Oertelt-Prigione ◽  
Rosemary Morgan ◽  
Sabra Klein ◽  
◽  
...  

The COVID-19 global pandemic is accelerating investigations for effective vaccines and repurposable validated therapeutics [...]

2018 ◽  
Vol 178 ◽  
pp. 57-72 ◽  
Author(s):  
Roberta Baetta ◽  
Marta Pontremoli ◽  
Alma Martinez Fernandez ◽  
Corinne M. Spickett ◽  
Cristina Banfi

Author(s):  
Annemarie Schumacher Dimech ◽  
Maria Teresa Ferretti ◽  
Else C Sandset ◽  
Antonella Santuccione Chadha

2021 ◽  
Vol 30 (11) ◽  
pp. 1637-1646 ◽  
Author(s):  
Ute Seeland ◽  
János Nemcsik ◽  
Mai Tone Lønnebakken ◽  
Karolina Kublickiene ◽  
Helena Schluchter ◽  
...  

2020 ◽  
Vol 55 ◽  
pp. 22-27 ◽  
Author(s):  
Erik Zettersten ◽  
Gabriella Jäderling ◽  
Max Bell ◽  
Emma Larsson

2019 ◽  
Vol 10 ◽  
Author(s):  
Alexandra Kautzky-Willer ◽  
Mia von Euler ◽  
Sabine Oertelt-Prigione

2020 ◽  
Vol 134 (16) ◽  
pp. 2203-2207
Author(s):  
Paul J. Connelly ◽  
Karin A.M. Jandeleit-Dahm ◽  
Christian Delles

Abstract Cardiovascular disease (CVD) is a leading cause of global mortality in men and women. The prevalence, pathophysiology, clinical manifestations and outcomes of CVD observed in these two populations is being increasingly recognized as distinct. In this editorial, we provide an overview of mechanisms related to differences in vascular pathophysiology between men and women and explore the contributions of both sex and gender.


2017 ◽  
Vol 10 (1) ◽  
pp. 44-55 ◽  
Author(s):  
Hanan G. Eltumi ◽  
Osama A. Tashani

Introduction: An increasing body of literature on sex and gender differences in pain sensitivity has been accumulated in recent years. There is also evidence from epidemiological research that painful conditions are more prevalent in older people. The aim of this narrative review is to critically appraise the relevant literature investigating the presence of age and sex differences in clinical and experimental pain conditions. Methods: A scoping search of the literature identifying relevant peer reviewed articles was conducted on May 2016. Information and evidence from the key articles were narratively described and data was quantitatively synthesised to identify gaps of knowledge in the research literature concerning age and sex differences in pain responses. Results: This critical appraisal of the literature suggests that the results of the experimental and clinical studies regarding age and sex differences in pain contain some contradictions as far as age differences in pain are concerned. While data from the clinical studies are more consistent and seem to point towards the fact that chronic pain prevalence increases in the elderly findings from the experimental studies on the other hand were inconsistent, with pain threshold increasing with age in some studies and decreasing with age in others. Conclusion: There is a need for further research using the latest advanced quantitative sensory testing protocols to measure the function of small nerve fibres that are involved in nociception and pain sensitivity across the human life span. Implications: Findings from these studies should feed into and inform evidence emerging from other types of studies (e.g. brain imaging technique and psychometrics) suggesting that pain in the older humans may have unique characteristics that affect how old patients respond to intervention.


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