XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in Chinese Population: A Case–Control Study

XAB2 protein (xeroderma pigmentosum group A-binding protein 2) plays a significant role in the nucleotide excision repair pathway. Polymorphisms in the XAB2 gene may have an effect on the capability of DNA repair and further contribute to the risk of developing various cancers. In order to investigate the relationship between XAB2 genetic variants and the risk of gastric cancer, we performed a hospital-based case–control study. XAB2 tagSNPs were selected and then genotyped by iPlex Gold Genotyping Assay and Sequenom MassArray. By performing logistic regression analysis, odds ratio (OR) and 95% confidence interval (CI) were used to estimate the association of XAB2 tagSNPs with the risk of gastric cancer. Our results showed that XAB2 rs794078AA genotype was associated with a significantly lower risk of gastric cancer compared with GG genotype with OR (95% CI) of 0.33 (0.12–0.91). Stratified analysis indicated a significantly decreased risk for gastric cancer among smokers with rs794078AA genotype compared with nonsmokers with GG genotype (OR = 0.11, 95% CI = 0.01–0.91, p = 0.040). The gene–gene interactions by multifactor dimensionality reduction (MDR) showed that tagSNP rs794078 was the best predictive element for gastric cancers (Testing Bal. Acc = 51.68%, p = 0.055, cross-validation consistency = 9). Therefore, the XAB2 tagSNP rs794078 may play an important role in the development of gastric cancer.

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XAB2 TagSNP is Associated with the Risk of Gastric Cancer in Chinese Population:a case-control study

10.21203/rs.2.14847/v1 ◽

2019 ◽

Author(s):

Yuning Xie ◽

Yuan Yu ◽

Hongjiao Wu ◽

Hui Gao ◽

Zhengbang Yang ◽

...

Keyword(s):

Gastric Cancer ◽

Dna Repair ◽

Case Control Study ◽

Excision Repair ◽

Case Control ◽

Nucleotide Excision Repair Pathway ◽

Group A ◽

Stratified Analysis ◽

Xeroderma Pigmentosum Group A ◽

Control Study

Abstract Background: XAB2 protein (xeroderma pigmentosum group A-binding protein 2) plays a significant role in the nucleotide excision repair pathway and transcription coupled DNA repair. Polymorphisms in XAB2 gene may effect on the capability of DNA repair and further contribute to the risk of developing various cancers. Methods: in order to investigate the relationship between XAB2 genetic variants and the risk of gastric cancer, we performed a hospital-based case-control study. XAB2 tagSNPs were genotyped by using iPlex Gold Genotyping Asssy and Sequenom MassArray. By conducting logistic regression, odds ratio (OR) and 95% confidence interval (CI) were used to represent the association of XAB2 tagSNPs with the risk of gastric cancer. Results: Our results showed that XAB2 rs794078 AA genotype was associated with a significantly lower risk of gastric cancer compared with GG genotype with OR (95%CI) of 0.33(0.12-0.91). Stratified analysis indicated a significantly decreased risk for gastric cancer among smokers with rs794078 AA genotype compared with non-smokers with GG genotype (OR=0.11, 95%CI=0.01-0.91, P=0.040). The gene-gene interactions by multifactor dimensionality reduction (MDR) showed that tagSNP rs794078 was the best predictive elements for gastric cancers (Testing Bal. Acc=51.68%, P=0.055, cross-validation consistency=9). Conclusion: The XAB2 tagSNP rs794078 were significantly associated with the risk of gastric cancer in Chinese population, which proved the important role of XAB2 in the development of gastric cancer.

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Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case–control study

Carcinogenesis ◽

10.1093/carcin/bgi330 ◽

2006 ◽

Vol 27 (7) ◽

pp. 1377-1385 ◽

Cited By ~ 71

Author(s):

Leah E. Mechanic ◽

Robert C. Millikan ◽

Jon Player ◽

Allan René de Cotret ◽

Scott Winkel ◽

...

Keyword(s):

Breast Cancer ◽

African Americans ◽

Nucleotide Excision Repair ◽

Case Control Study ◽

Excision Repair ◽

Population Based ◽

Case Control ◽

Nucleotide Excision ◽

Repair Genes ◽

Control Study

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Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study

Turkish Journal of Surgery ◽

10.47717/turkjsurg.2021.5097 ◽

2021 ◽

Vol 37 (1) ◽

pp. 41-48 ◽

Cited By ~ 1

Author(s):

Adem Akçakaya ◽

Nurcan Ünver ◽

Tuğba Aydoğan Kiriş ◽

Mehmet Güzel ◽

Fatma Betül Akçakaya ◽

...

Keyword(s):

Gastric Cancer ◽

Case Control Study ◽

Demographic Data ◽

Survival Rates ◽

Case Control ◽

Loss Of Function ◽

Group A ◽

Gastric Cancer Patients ◽

Control Study ◽

E Cadherin

Objective: The loss of function of the E-cadherin (CDH1) gene with -160 C→A and -347 G→GA polymorphisms is regarded as a critical step for gastric cancer. It was aimed to investigate possible association of these polymorphisms and immunoexpression of E-cadherin with gastric cancer. Material and Methods: Gastric adenocarcinoma patients and individuals with benign gastric pathologies were included in this case-control study. Demographic data and pathological findings were recorded. Immunohistochemical staining of E-cadherin expression and analysis of -160 C→A and -347 G→GA polymorphisms were done. Differences between allele frequencies of -160 C→A and -347 G→GA polymorphisms and expression of E-cadherin were the primary outcomes. Results: There were 78 gastric cancer patients (Group A) and 113 individuals with benign gastric pathologies (Group B). The number of male patients and mean age were higher in Group A (p< 0.001). -160 C→A and 347 G→GA polymorphisms and their allelic distributions showed no difference between the groups (p> 0.05 for all). There was a significant association between -160 C→A polymorphism and grade of E-cadherin expression (p= 0.013). There were no significant differences between survival rates with -160 C→A, 347 G→GA and intensity of E-cadherin expression (p> 0.05 for all). There was no significant association between -160 C→A and -347 G→GA polymorphisms and gastric cancer. Conclusion: There was no impact of E-cadherin expression on tumoral features and survival in gastric cancer. -160 C→A polymorphism may influence the expression of E-cadherin in gastric cancer.

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A case-control study on association of nucleotide excision repair polymorphisms and its interaction with environment factors with the susceptibility to non-melanoma skin cancer

Oncotarget ◽

10.18632/oncotarget.20942 ◽

2017 ◽

Vol 8 (46) ◽

pp. 80994-81000 ◽

Cited By ~ 1

Author(s):

Yan-Ling Li ◽

Feng Wei ◽

Yu-Ping Li ◽

Li-Hua Zhang ◽

Yan-Zhi Bai

Keyword(s):

Skin Cancer ◽

Nucleotide Excision Repair ◽

Case Control Study ◽

Excision Repair ◽

Case Control ◽

Environment Factors ◽

Non Melanoma Skin Cancer ◽

Nucleotide Excision ◽

Control Study ◽

Melanoma Skin

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APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/5736175 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Jiabin Liu ◽

Wei Jia ◽

Rui-Xi Hua ◽

Jinhong Zhu ◽

Jiao Zhang ◽

...

Keyword(s):

Genome Stability ◽

Case Control Study ◽

Excision Repair ◽

Case Control ◽

Chinese Children ◽

Damage Repair ◽

Life Threatening ◽

Base Excision ◽

Stratified Analysis ◽

Control Study

Neuroblastoma is a life-threatening extracranial solid tumor, preferentially occurring in children. However, its etiology remains unclear. APEX1 is a critical gene in the base excision repair (BER) system responsible for maintaining genome stability. Given the potential effects of APEX1 polymorphisms on the ability of the DNA damage repair, many studies have investigated the association between these variants and susceptibility to several types of cancer but not neuroblastoma. Here, we conducted a three-center case-control study to evaluate the association between APEX1 polymorphisms (rs1130409 T>G, rs1760944 T>G, and rs3136817 T>C) and neuroblastoma risk in Chinese children, consisting of 469 cases and 998 controls. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated to evaluate the associations. No significant association with neuroblastoma risk was found for the studied APEX1 polymorphisms in the single locus or combination analysis. Interestingly, stratified analysis showed that rs1130409 GG genotype significantly reduced the risk of tumor in males. Furthermore, we found that carriers with 1-3 protective genotypes had a lower neuroblastoma risk in the children older than18 months and male, when compared to those without protective genotypes. In summary, our data indicate that APEX1 gene polymorphisms may have a weak effect on neuroblastoma susceptibility. These findings should be further validated by well-designed studies with larger sample size.

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