XAB2 TagSNP is Associated with the Risk of Gastric Cancer in Chinese Population:a case-control study
Abstract Background: XAB2 protein (xeroderma pigmentosum group A-binding protein 2) plays a significant role in the nucleotide excision repair pathway and transcription coupled DNA repair. Polymorphisms in XAB2 gene may effect on the capability of DNA repair and further contribute to the risk of developing various cancers. Methods: in order to investigate the relationship between XAB2 genetic variants and the risk of gastric cancer, we performed a hospital-based case-control study. XAB2 tagSNPs were genotyped by using iPlex Gold Genotyping Asssy and Sequenom MassArray. By conducting logistic regression, odds ratio (OR) and 95% confidence interval (CI) were used to represent the association of XAB2 tagSNPs with the risk of gastric cancer. Results: Our results showed that XAB2 rs794078 AA genotype was associated with a significantly lower risk of gastric cancer compared with GG genotype with OR (95%CI) of 0.33(0.12-0.91). Stratified analysis indicated a significantly decreased risk for gastric cancer among smokers with rs794078 AA genotype compared with non-smokers with GG genotype (OR=0.11, 95%CI=0.01-0.91, P=0.040). The gene-gene interactions by multifactor dimensionality reduction (MDR) showed that tagSNP rs794078 was the best predictive elements for gastric cancers (Testing Bal. Acc=51.68%, P=0.055, cross-validation consistency=9). Conclusion: The XAB2 tagSNP rs794078 were significantly associated with the risk of gastric cancer in Chinese population, which proved the important role of XAB2 in the development of gastric cancer.