scholarly journals Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study

2021 ◽  
Vol 37 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Adem Akçakaya ◽  
Nurcan Ünver ◽  
Tuğba Aydoğan Kiriş ◽  
Mehmet Güzel ◽  
Fatma Betül Akçakaya ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Demographic Data ◽  
Survival Rates ◽  
Case Control ◽  
Loss Of Function ◽  
Group A ◽  
Gastric Cancer Patients ◽  
Control Study ◽  
E Cadherin

Objective: The loss of function of the E-cadherin (CDH1) gene with -160 C→A and -347 G→GA polymorphisms is regarded as a critical step for gastric cancer. It was aimed to investigate possible association of these polymorphisms and immunoexpression of E-cadherin with gastric cancer. Material and Methods: Gastric adenocarcinoma patients and individuals with benign gastric pathologies were included in this case-control study. Demographic data and pathological findings were recorded. Immunohistochemical staining of E-cadherin expression and analysis of -160 C→A and -347 G→GA polymorphisms were done. Differences between allele frequencies of -160 C→A and -347 G→GA polymorphisms and expression of E-cadherin were the primary outcomes. Results: There were 78 gastric cancer patients (Group A) and 113 individuals with benign gastric pathologies (Group B). The number of male patients and mean age were higher in Group A (p< 0.001). -160 C→A and 347 G→GA polymorphisms and their allelic distributions showed no difference between the groups (p> 0.05 for all). There was a significant association between -160 C→A polymorphism and grade of E-cadherin expression (p= 0.013). There were no significant differences between survival rates with -160 C→A, 347 G→GA and intensity of E-cadherin expression (p> 0.05 for all). There was no significant association between -160 C→A and -347 G→GA polymorphisms and gastric cancer. Conclusion: There was no impact of E-cadherin expression on tumoral features and survival in gastric cancer. -160 C→A polymorphism may influence the expression of E-cadherin in gastric cancer.

S1609 Clinical Evaluation of Helicobacter pylori Tyrosine-Phosphorylated CagA in Diffuse-Type Gastric Cancer Patients: A Case-Control Study

2008 ◽  
Vol 134 (4) ◽  
pp. A-234
Author(s):  
Yoshihiro Wada ◽  
Masanori Ito ◽  
Shunsuke Takata ◽  
Shosuke Kitamura ◽  
Akemi Takamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cancer Patients ◽  
Clinical Evaluation ◽  
Case Control Study ◽  
Case Control ◽  
Diffuse Type ◽  
Gastric Cancer Patients ◽  
Diffuse Type Gastric Cancer ◽  
Control Study

scholarly journals Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients: the AMNESIA Case-Control Study

2017 ◽  
Vol 24 (5) ◽  
pp. 1082-1089 ◽  
Author(s):  
Filippo Pietrantonio ◽  
Giovanni Fucà ◽  
Federica Morano ◽  
Annunziata Gloghini ◽  
Simona Corso ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Metastatic Gastric Cancer ◽  
Case Control ◽  
Her2 Positive ◽  
Primary Resistance ◽  
Gastric Cancer Patients ◽  
Control Study

scholarly journals The association between dietary inflammatory index and gastric cancer: A case control study

2020 ◽  
Author(s):  
Ahmad Mujtaba Barekzai ◽  
Azadeh Aminianfar ◽  
Seyed Mohammad Mousavi ◽  
Ahmad Esmaillzadeh
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Dietary Assessment ◽  
Positive Association ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Significant Positive Association ◽  
Inflammatory Index ◽  
Gastric Cancer Patients ◽  
Control Study

Abstract Background No report is available about diet-disease associations in the understudied region of Afghanistan. Although inflammatory potential of diet has been linked with several cancers, information about gastric cancer is scarce. This study aimed to investigate the relationship between dietary inflammatory index (DII) and odds of gastric cancer in Afghanistan. Methods In this hospital-based case-control study, we enrolled 90 newly-diagnosed cases of gastric cancer and 180 age (± 5) and sex-matched controls. All cases were pathologically confirmed gastric cancer patients, with no history of any type of other pathologically confirmed cancers. Controls were healthy individuals and relatives of patients in the hospital. Dietary assessment was done by a pre-tested food frequency questionnaire. DII was calculated based on energy-adjusted amounts of several foods and nutrients with inflammatory or anti-inflammatory potential, as introduced by earlier studies. Results Mean age of study participants was 54 years, of them 73% were males. After adjustment for age and sex, individuals in the highest tertile of DII were 2.47 times (95% CI: 1.31–4.66) more likely to have gastric cancer compared with those in the lowest tertile. Further adjustment for other potential confounders did not substantially affect the association; such that participants with the greatest DII had approximately 3.59 times (95% CI: 1.16, 11.02) increased odds of gastric cancer than those with the lowest adherence. Additional adjustment for BMI strengthened the association (OR: 3.75; 95% CI: 1.14–12.30). Conclusion We found a significant positive association between inflammatory potential of diet and risk of gastric cancer. Further studies with prospective nature are required to confirm this association.

scholarly journals A case-control study of the periodontal condition in gastric cancer patients

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Nikolaos Andreas Chrysanthakopoulos ◽  
Aggelos Antonios Oikonomou
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Periodontal Condition ◽  
Gastric Cancer Patients ◽  
Control Study

scholarly journals The Association Between Index of Nutritional Quality (INQ) and Gastric Cancer and Evaluation of Nutrient Intakes of Gastric Cancer Patients: A Case-Control Study

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Farhad Vahid ◽  
Golaleh Rahmani ◽  
Alireza Jafari Naeini ◽  
Habib Falahnejad ◽  
Sayed Hossein Davoodi
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Nutritional Quality ◽  
Case Control Study ◽  
Case Control ◽  
Nutrient Intakes ◽  
Gastric Cancer Patients ◽  
Control Study

scholarly journals Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167615 ◽  
Author(s):  
Hee Jung Park ◽  
Ji Yong Ahn ◽  
Hwoon-Yong Jung ◽  
Jeong Hoon Lee ◽  
Kee Wook Jung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Clinical Characteristics ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Gastric Cancer Patients ◽  
Control Study

scholarly journals Gastric cancer in autoimmune gastritis: A case-control study from the German centers of the staR project on gastric cancer research

2019 ◽  
Vol 8 (2) ◽  
pp. 175-184 ◽  
Author(s):  
Friederike Weise ◽  
Michael Vieth ◽  
Dirk Reinhold ◽  
Johannes Haybaeck ◽  
Elisabetta Goni ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Pernicious Anemia ◽  
Case Control Study ◽  
Survival Rates ◽  
Case Control ◽  
Autoimmune Gastritis ◽  
Siewert Type Ii ◽  
Presenting Symptoms ◽  
Increased Risk ◽  
Control Study

Objectives Patients with autoimmune gastritis (AIG) are reported to have an increased risk of developing gastric cancer (GC). In this study, we assess the characteristics and outcomes of GC patients with AIG in a multicenter case-control study. Methods Between April 2013 and May 2017, patients with GC, including cancers of the esophagogastric junction (EGJ) Siewert type II and III, were recruited. Patients with histological characteristics of AIG were identified and matched in a 1:2 fashion for age and gender to GC patients with no AIG. Presenting symptoms were documented using a self-administered questionnaire. Results Histological assessment of gastric mucosa was available for 572/759 GC patients. Overall, 28 (4.9%) of GC patients had AIG (67 ± 9 years, female-to-male ratio 1.3:1). In patients with AIG, GC was more likely to be localized in the proximal (i.e. EGJ, fundus, corpus) stomach (odds ratio (OR) 2.7, 95% confidence interval (CI) 1.0–7.1). In GC patients with AIG, pernicious anemia was the leading clinical sign (OR 22.0, 95% CI 2.6–187.2), and the most common indication for esophagogastroduodenoscopy (OR 29.0, 95% CI 7.2–116.4). GC patients with AIG were more likely to present without distant metastases (OR 6.2, 95% CI 1.3–28.8) and to be treated with curative intention (OR 3.0, 95% CI 1.0–9.0). The five-year survival rates with 95% CI in GC patients with and with no AIG were 84.7% (83.8–85.6) and 53.5% (50.9–56.1), respectively (OR 0.25, 95% CI 0.08–0.75, p = 0.001). Conclusions Pernicious anemia leads to earlier diagnosis of GC in AIG patients and contributes significantly to a better clinical outcome.

Mo1072 Can Endoscopic Bleeding Control Improve the Prognosis of Advanced Gastric Cancer Patients? A Retrospective Case-Control Study

2016 ◽  
Vol 83 (5) ◽  
pp. AB450-AB451
Author(s):  
Ji Yong Ahn ◽  
Hwoon-Yong Jung ◽  
Hee Kyong Na ◽  
Jeong Hoon Lee ◽  
Kee Wook Jung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Bleeding Control ◽  
Retrospective Case ◽  
Gastric Cancer Patients ◽  
Control Study

Clinical characteristics and outcomes for gastric cancer patients over age 80: A retrospective case-control study.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 30-30
Author(s):  
Hee-Jung Park ◽  
Ji Yong Ahn ◽  
Hwoon-Yong JUNG ◽  
Jeong Hoon Lee ◽  
Kwi-Sook Choi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Elderly Patients ◽  
Cancer Patients ◽  
Curative Resection ◽  
Case Control Study ◽  
Case Control ◽  
Asa Score ◽  
Gastric Cancer Patients ◽  
Control Study

30 Background: The average human life expectancy is increasing worldwide, thus proportion of elderly gastric cancer patients are also increasing. In this study, we investigated the clinical and oncologic outcomes of gastric cancer in patients over 80 years old through a case-control study. Methods: From January 2004 to December 2010, 291 patients aged over 81 years old (case group) were diagnosed and treated with gastric cancer at the Asan Medical Center. During the same period, 291 patients aged 18 to 80 years old were selected as control group. The clinical findings, histopathological parameters, and clinical outcomes of gastric cancer were reviewed retrospectively and compared between the two groups. Results: There were significant differences in overall 5-year survival rate between the two groups (30.9% vs 73.8%, P< 0.001). When analysis was confined to resectable elderly patients with favorable performance of American Society of Anesthesiologists (ASA) score 1 or 2, curative resection group showed significantly better overall 3- and 5-year survival rate than the conservative treatment group (73.7% and 58.8% vs 29.8% and 0%, respectively). In multivariate analysis, lower BMI and advanced TNM stage were found to be independent prognostic predictors for poorer survival. ASA score showed borderline significance for predictors for poorer survival (P=0.087). Conclusions: Although elderly patients showed advanced stage at diagnosis and poor prognosis compared to non-elderly patients, elderly patients with good performance could benefit from curative resection of gastric cancer, thus the clinical decision whether to undergo curative resection or conservative management should be made on individualized approach.

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