scholarly journals Immune Responses in Pigs Induced by Recombinant DNA Vaccine Co-Expressing Swine IL-18 and Membrane Protein of Porcine Reproductive and Respiratory Syndrome Virus

2012 ◽  
Vol 13 (5) ◽  
pp. 5715-5728 ◽  
Author(s):  
Xiaodong Zhang ◽  
Xiaoli Wang ◽  
Lianzhi Mu ◽  
Zhuang Ding
Keyword(s):  
Membrane Protein ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Recombinant Dna ◽  
Respiratory Syndrome Virus

scholarly journals Evaluation of Th17 immune responses of recombinant DNA vaccine encoding GRA14 and ROP13 genes against Toxoplasma gondii in BALB/c mice

2021 ◽  
pp. 105150
Author(s):  
Mohammad Fatollahzadeh ◽  
Abbasali Eskandarian ◽  
Hossein Yousofi Darani ◽  
Abdol Sattar Pagheh ◽  
Ehsan Ahmadpour
Keyword(s):  
Toxoplasma Gondii ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Recombinant Dna

scholarly journals A polyvalent influenza DNA vaccine applied by needle-free intradermal delivery induces cross-reactive humoral and cellular immune responses in pigs

Vaccine ◽  
2016 ◽  
Vol 34 (32) ◽  
pp. 3634-3640 ◽  
Author(s):  
Marie Borggren ◽  
Jens Nielsen ◽  
Ingrid Karlsson ◽  
Tina S. Dalgaard ◽  
Ramona Trebbien ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Cellular Immune Responses ◽  
Intradermal Delivery ◽  
Cellular Immune

scholarly journals Porcine Reproductive and Respiratory Syndrome Virus: Immune Escape and Application of Reverse Genetics in Attenuated Live Vaccine Development

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 480
Author(s):  
Honglei Wang ◽  
Yangyang Xu ◽  
Wenhai Feng
Keyword(s):  
Immune Responses ◽  
Reverse Genetics ◽  
Vaccine Development ◽  
Immune Escape ◽  
Rna Virus ◽  
Economic Losses ◽  
Respiratory Syndrome Virus ◽  
Live Vaccines ◽  
Host Immune Responses ◽  
Inactivated Vaccines

Porcine reproductive and respiratory syndrome virus (PRRSV), an RNA virus widely prevalent in pigs, results in significant economic losses worldwide. PRRSV can escape from the host immune response in several processes. Vaccines, including modified live vaccines and inactivated vaccines, are the best available countermeasures against PRRSV infection. However, challenges still exist as the vaccines are not able to induce broad protection. The reason lies in several facts, mainly the variability of PRRSV and the complexity of the interaction between PRRSV and host immune responses, and overcoming these obstacles will require more exploration. Many novel strategies have been proposed to construct more effective vaccines against this evolving and smart virus. In this review, we will describe the mechanisms of how PRRSV induces weak and delayed immune responses, the current vaccines of PRRSV, and the strategies to develop modified live vaccines using reverse genetics systems.

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