scholarly journals Structural Variations in Articular Cartilage Matrix Are Associated with Early-Onset Osteoarthritis in the Spondyloepiphyseal Dysplasia Congenita (Sedc) Mouse

2013 ◽  
Vol 14 (8) ◽  
pp. 16515-16531 ◽  
Author(s):  
David Macdonald ◽  
Ryan Squires ◽  
Shaela Avery ◽  
Jason Adams ◽  
Melissa Baker ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Early Onset ◽  
Cartilage Matrix ◽  
Structural Variations ◽  
Spondyloepiphyseal Dysplasia ◽  
Spondyloepiphyseal Dysplasia Congenita

scholarly journals A novel COL2A1 mutation causing spondyloepiphyseal dysplasia congenita in a Chinese family

2021 ◽  
Vol 35 (4) ◽  
Author(s):  
Tangjun Zhou ◽  
Xiao Yang ◽  
Zhiqian Chen ◽  
Yifan Zhou ◽  
Xiankun Cao ◽  
...  
Keyword(s):  
Chinese Family ◽  
Spondyloepiphyseal Dysplasia ◽  
Spondyloepiphyseal Dysplasia Congenita ◽  
Col2a1 Mutation

scholarly journals The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover

2006 ◽  
Vol 14 (6) ◽  
pp. 597-608 ◽  
Author(s):  
S.W. Jones ◽  
S.M.V. Brockbank ◽  
M.L. Mobbs ◽  
N.J. Le Good ◽  
S. Soma-Haddrick ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
G Protein ◽  
Cartilage Matrix ◽  
G Protein Coupled Receptor ◽  
Chondrocyte Hypertrophy ◽  
G Protein Coupled

Double heterozygosity for pseudoachondroplasia and spondyloepiphyseal dysplasia congenita

2001 ◽  
Vol 104 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Sheila Unger ◽  
Jarmo Korkko ◽  
Deborah Krakow ◽  
Ralph S. Lachman ◽  
David L. Rimoin ◽  
...  
Keyword(s):  
Spondyloepiphyseal Dysplasia ◽  
Spondyloepiphyseal Dysplasia Congenita ◽  
Double Heterozygosity

Neurosurgical Interventions for Spondyloepiphyseal Dysplasia Congenita: Clinical Presentation and Assessment of the Literature

2013 ◽  
Vol 80 (3-4) ◽  
pp. 437.e1-437.e8 ◽  
Author(s):  
Anand Veeravagu ◽  
Shivanand P. Lad ◽  
Joaquin Q. Camara-Quintana ◽  
Bowen Jiang ◽  
Lawrence Shuer
Keyword(s):  
Clinical Presentation ◽  
Spondyloepiphyseal Dysplasia ◽  
Spondyloepiphyseal Dysplasia Congenita

scholarly journals Effect of load on articular cartilage matrix and the development of guinea-pig osteoarthritis

2001 ◽  
Vol 9 (5) ◽  
pp. 447-453 ◽  
Author(s):  
L. Wei ◽  
A. Hjerpe ◽  
B.H. Brismar ◽  
O. Svensson
Keyword(s):  
Articular Cartilage ◽  
Guinea Pig ◽  
Cartilage Matrix

The Role of Soft Connective Tissue in the Response of Pig Articular Cartilage in Organ Culture to Excess of Retinol

1973 ◽  
Vol 13 (1) ◽  
pp. 205-219
Author(s):  
M. E. J. BARRATT
Keyword(s):  
Articular Cartilage ◽  
Connective Tissue ◽  
Organ Culture ◽  
Growing Pigs ◽  
Cartilage Matrix ◽  
Normal Medium ◽  
Chondroid Tissue ◽  
Extensive Degradation

The action of excess retinol on articular cartilage from growing pigs was studied in organ culture. Retinol had little or no effect on explants of articular cartilage alone, but if the explants were cut so as to include some of the marrow tissue in the invasion cavities, or were cultivated near or in contact with capsular tissue, retinol caused extensive degradation of the cartilage matrix, as indicated by loss of metachromatic staining properties. Many chondrocytes were released from their capsules and assumed a fibroblast-like form. Two types of regeneration were seen. In control explants that included part of the invasion zone, cells below the explant laid down a metachromatic matrix; in similar explants cultured in the presence of retinol, a non-metachromatic osteoid-like tissue was formed at this site. There was little recovery when retinol-treated explants were transferred to normal medium, although both osteoid and chondroid tissue were sometimes regenerated.

scholarly journals COL2A1 Gene Mutations: Mechanisms of Spondyloepiphyseal Dysplasia Congenita

2019 ◽  
Vol Volume 12 ◽  
pp. 235-238
Author(s):  
Raffaella Nenna ◽  
Arianna Turchetti ◽  
Gerarda Mastrogiorgio ◽  
Fabio Midulla
Keyword(s):  
Gene Mutations ◽  
Spondyloepiphyseal Dysplasia ◽  
Spondyloepiphyseal Dysplasia Congenita ◽  
Em Gene
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