scholarly journals High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints

2019 ◽  
Vol 20 (4) ◽  
pp. 952 ◽  
Author(s):  
Michael-Antony Lisio ◽  
Lili Fu ◽  
Alicia Goyeneche ◽  
Zu-hua Gao ◽  
Carlos Telleria
Keyword(s):  
Ovarian Cancer ◽  
Reproductive Tract ◽  
Scientific Discovery ◽  
Molecular Genetic ◽  
Treatment Strategies ◽  
Female Reproductive Tract ◽  
Clinical Aspects ◽  
Anatomical Site ◽  
High Grade ◽  
Serous Ovarian Cancer

Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled recent ameliorations in the outcomes of many other cancers, the rates of mortality for ovarian cancer have been stagnant since around 1980. Yet despite the grim outlook, progress is being made towards better understanding the fundamental biology of this disease and how its biology in turn influences clinical behaviour. It has long been evident that ovarian cancer is not a unitary disease but rather a multiplicity of distinct malignancies that share a common anatomical site upon presentation. Of these, the high-grade serous subtype predominates in the clinical setting and is responsible for a disproportionate share of the fatalities from all forms of ovarian cancer. This review aims to provide a detailed overview of the clinical-pathological features of ovarian cancer with a particular focus on the high-grade serous subtype. Along with a description of the relevant clinical aspects of this disease, including novel trends in treatment strategies, this text will inform the reader of recent updates to the scientific literature regarding the origin, aetiology and molecular-genetic basis of high-grade serous ovarian cancer (HGSOC).

Fallopian tubes and ovarian cancer (Literature review)

2019 ◽  
pp. 92-95
Author(s):  
D.G. Sumtsov ◽  
◽  
M.L. Kusyomenska ◽  
G.A. Sumtsov ◽  
◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Literature Review ◽  
Preventive Measures ◽  
Disease Incidence ◽  
Molecular Genetic ◽  
Serous Ovarian Cancer ◽  
Fallopian Tubes ◽  
Key Words Ovarian Cancer ◽  
Pelvic Peritoneum ◽  
Opportunistic Salpingectomy

In the literature review the authors present an analysis of the current stateproblem of ovarian cancer and ways of its possible solution. According to clinicalobservations and conducted in recent decades by morphological,immunohistochemical and molecular genetic studies it is fairly proved that theprimary cause of serous ovarian cancer is the pathology of the mucous layer offallopian tube. In the fallopian tube as a result of ciculation of inflammation andcarcinogens elements arises dysplasia of the mucosa with the development of thepreinvasive and initial invasive carcinoma with subsequent damage of the ovariesand pelvic peritoneum. Retrospective studies of a significant number of women’shealth status who had a deligation or removal of fallopian tubes in previous years showed a decrease in the disease incidence of serous ovarian cancer from 30 to 90%. The conclusions about the possibility of preventive measures of ovariancancer by opportunistic salpingectomy at post-productive age are made. In many world countries (Canada, China, France, Italy, Austria) the introduction of such a method of prevention has been started. We believe that in Ukraine there is an urgent need and all possibilities to solve this problem. Key words: ovarian cancer, preventive measures, opportunistic salpingectomy.

scholarly journals Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer

2019 ◽  
Vol 6 ◽  
pp. 156-162 ◽  
Author(s):  
Surrin S. Deen ◽  
Frank Riemer ◽  
Mary A. McLean ◽  
Andrew B. Gill ◽  
Joshua D. Kaggie ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Sodium Mri ◽  
Tumour Cellularity

Molecular predictors of the outcome of paclitaxel plus carboplatin neoadjuvant therapy in high-grade serous ovarian cancer patients

2021 ◽  
Author(s):  
Anna P. Sokolenko ◽  
Tatiana V. Gorodnova ◽  
Ilya V. Bizin ◽  
Ekaterina Sh. Kuligina ◽  
Khristina B. Kotiv ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Neoadjuvant Therapy ◽  
Cancer Patients ◽  
High Grade ◽  
Serous Ovarian Cancer

scholarly journals Precision radiogenomics: fusion biopsies to target tumour habitats in vivo

2021 ◽  
Author(s):  
Mireia Crispin-Ortuzar ◽  
Evis Sala
Keyword(s):  
Ovarian Cancer ◽  
Ct Scans ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
High Degree ◽  
Degree Of Heterogeneity

SummaryHigh-grade serous ovarian cancer lesions display a high degree of heterogeneity on CT scans. We have recently shown that regions with distinct imaging profiles can be accurately biopsied in vivo using a technique based on the fusion of CT and ultrasound scans.

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